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Öğe Assessment of Right Ventricular Systolic Functions in Patients with Chronic Renal Failure before and after Hemodialysis(Elsevier Science Inc, 2013) Yildiz, Abdulkadir; Akyuz, Abdurrahman; Yuksel, Murat; Oylumlu, Mustafa; Bilik, Mehmet Zihni; Polat, Nihat; Akil, Mehmet Ata[Abstract Not Available]Öğe Evaluation of Platelet to Lymphocyte Ratio to Predict No-Reflow in Patients With Acute Myocardial Infarction(Elsevier Science Inc, 2013) Yildiz, Abdulkadir; Tuncez, Abdullah; Polat, Nihat; Acet, Halit; Oylumlu, Mustafa; Yuksel, Murat; Akyuz, Abdurrahman[Abstract Not Available]Öğe Increased echocardiographic epicardial fat thickness is related to impaired diurnal blood pressure profiles(Taylor & Francis Ltd, 2012) Ertas, Faruk; Kaya, Hasan; Acet, Halit; Cil, Habib; Akyuz, Abdurrahman; Islamoglu, Yahya; Tekbas, EbruObjective. Epicardial fat has been proposed as a new cardiometabolic risk factor. Although epicardial fat thickness (EFT) is associated with hypertension, the relationship between diurnal blood pressure profiles and EFT is still unknown. The purpose of this study is to investigate the association between the echocardiographic EFT and diurnal blood pressure profiles in hypertensive patients. Methods. After the ambulatory blood pressures of 123 patients were monitored, they were divided into three groups according to the clinical diagnoses: 41 patients (33.3%) were in the normotensive group, 40 patients (32.5%) were in the dipper hypertensive group and 42 patients (34.1%) were in the non-dipper hypertensive group. All participants underwent transthoracic echocardiography and ambulatory blood pressure monitoring to measure the EFT and blood pressure responses. Results. The mean EFT measurements of the dipper group were significantly higher than the normotensive group (6.5 +/- 0.6 vs 5.8 +/- 0.6; p < 0.0001). On the other hand, the mean EFTs of the non-dipper group were also significantly higher than the dipper group (7.4 +/- 0.7 vs 6.5 +/- 0.6, p < 0.0001). An EFT of >= 7 mm predicted the non-dipper profile in hypertensive patients with 74% sensitivity and 71% specificity (receiving operator characteristic area under the curve: 0.826, 95% CI 0.738-0.913; p < 0.0001). EFT was associated with both dipper (OR 8.9, 95% CI 3.03-26.3; p < 0.0001) and non-dipper blood pressure profiles (OR 12.3, 95% CI 1.75-86.31; p < 0.0001), and this relationship was also independent from all the risk factors. Conclusion. Echocardiographic EFT assessment is independently associated with impaired diurnal blood pressure profiles in the hypertensive individuals. Thus, the echocardiographic assessment of the EFT may be helpful in cardiometabolic risk stratification and therapeutic interventions.Öğe Myocardial ischemia induced by three-vessel coronary-cameral fistulas(Termedia Publishing House Ltd, 2014) Oylumlu, Mustafa; Yildiz, Abdulkadir; Yuksel, Murat; Akyuz, AbdurrahmanCoronary-cameral fistula is a scarce clinical entity, which is defined as an anomalous communication between any epicardial coronary artery and cardiac chambers or large vessels. We aimed to present a case of multiple coronary-cameral fistulas causing myocardial ischemia.Öğe A novel predictor of infarct-related artery patency before percutaneous intervention and in-hospital outcomes for ST-segment elevation myocardial infarction patients: serum bilirubin level(Termedia Publishing House Ltd, 2014) Acet, Halit; Ertas, Faruk; Akil, Mehmet Ata; Polat, Nihat; Aydin, Mesut; Akyuz, Abdurrahman; Aycicek, HilalIntroduction: Previous studies have reported a relationship between serum bilirubin levels and coronary artery disease (CAD). However, data are rare up to now regarding the relation of bilirubin levels with infarct-related artery (IRA) patency in the setting of ST-segment elevation myocardial infarction (STEMI). Moreover, previous studies reported that increased bilirubin was related to impaired post-intervention coronary flow. To our knowledge, the association between serum total bilirubin (TB) levels and pre-primary percutaneous coronary intervention (PCl) with patency of IRA flow in STEMI patients has not been investigated. Aim: To evaluate the association of TB with pre-primary PCl, coronary flow and in-hospital major adverse cardiac events (MACE) in patients with STEMI. Material and methods: A total of 360 consecutive patients with STEMI (mean age = 61.4+/-13.7 years) admitted within 12 h from the time of symptom onset were enrolled. Patients were divided into 2 groups based on the serum TB levels. We defined normal flow as pre-PCl TIMI 3 flow, while impaired flow was defined as pre-PCl TIMI 2 flow. Results: Pre-PCl impaired flow was higher in the TB group than pre-PCl normal flow (p < 0.001). In-hospital mortality and MACE were significantly higher in the high TB group (p = 0.002, p < 0.001 respectively). In the receiver operating characteristic curve analysis, TB > 0.825 mg/dl predicted impaired IRA flow before p-PCl with a sensitivity of 79% and specificity of 71%. Conclusions: The TB is an inexpensive and readily available marker for STEMI patients undergoing PCl. It can be used for risk stratification in this patient population.Öğe Platelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome(Turkish Soc Cardiology, 2015) Oylumlu, Mustafa; Yildiz, Abdulkadir; Oylumlu, Muhammed; Yuksel, Murat; Polat, Nihat; Bilik, Mehmet Zihni; Akyuz, AbdurrahmanObjective: Platelets and inflammatory cells are vital elements of acute coronary syndromes (ACS). Recent studies have shown that the platelet-to-lymphocyte ratio (PLR) is associated with several malignancies; however, there are not enough data in cardiovascular diseases. Therefore, the aim of this study was to explore the association between PLR and in-hospital mortality in patients with ACS. Methods: We retrospectively collected patients with ACS undergoing coronary angiography. Total and differential leukocyte counts were measured by an automated hematology analyzer. Results: This study is single-centered and observational. In total, 587 patients with a mean age of 61.8 +/- 13.1 years (68.4% male) were enrolled in the study. Patients were divided into 3 tertiles based on PLR levels. In-hospital mortality was significantly higher among patients in the upper PLR tertile when compared with the middle and lower PLR tertile groups [29 (14.8%) vs. 17 (8.7%) and 2 (1.0%); p<0.001]. In the multiple logistic regression analysis, a high level of PLR was an independent predictor of in-hospital mortality, together with age, total leukocyte count, and creatinine. Using a cutoff point of 142, the PLR predicted in-hospital mortality with a sensitivity of 69% and specificity of 63%. Conclusion: Different from other inflammatory markers and assays, PLR is an inexpensive and readily available biomarker that may be useful for cardiac risk stratification in patients with ACS.Öğe Serum Levels of IL-17 and IL-23 in Patients With Rheumatic Mitral Stenosis(Lippincott Williams & Wilkins, 2016) Bilik, Mehmet Zihni; Kaplan, Ibrahim; Polat, Nihat; Akil, Mehmet Ata; Akyuz, Abdurrahman; Acet, Halit; Yuksel, MuratRheumatic mitral valve stenosis (RMS) is a complication of rheumatic heart disease (RHD) and leads to significant morbidity and mortality. RHD is a chronic inflammatory and autoimmune disease that is associated with cytokine activities. The etiology of RMS is not fully understood yet. Interleukin (IL)-17 and IL-23 have a key role in development of the autoimmunity. The expression of these cytokines in RMS remains unclear. In this study, we investigated the serum levels of IL-17 and IL-23 in RMS patients compared to healthy subjects. A total of 35 patients admitted to cardiology outpatient clinic between December 2014 and May 2015 who were diagnosed with RMS formed the study group. Age- and gender-matched 35 healthy subjects were included as the control group. Statistical analyses were performed using SPSS 18.0 and P value <0.05 was considered as statistically significant. The patients with RMS had higher WBC count, hsCRP, systolic pulmonary artery pressure (PAPs), left atrial diameter (LAD), IL-17, and IL-23 levels compared to the control subjects. The levels of IL-17 (P = 0.012) and IL-23 (P = 0.004) were significantly higher in the RMS group. Correlation analysis revealed that IL-17 and IL-23 levels had a significant correlation with each other and with hsCRP and LAD. We demonstrated that serum levels of IL-17 and IL-23 are significantly higher in patients with RMS compared to those of healthy subjects. IL-17 and IL-23 expression may have a possible role in inflammatory processes that result in RMS development.Öğe An unusual co-anomaly: multiple coronary-cameral fistulas and left main coronary artery arising from the right sinus of Valsalva(Turkish Soc Cardiology, 2013) Yildiz, Abdulkadir; Inci, Umit; Akyuz, Abdurrahman; Oylumlu, Mustafa[Abstract Not Available]Öğe The Utility of the Platelet-Lymphocyte Ratio for Predicting No Reflow in Patients With ST-Segment Elevation Myocardial Infarction(Sage Publications Inc, 2015) Yildiz, Abdulkadir; Yuksel, Murat; Oylumlu, Mustafa; Polat, Nihat; Akyuz, Abdurrahman; Acet, Halit; Aydin, MesutThe aim of the study was to evaluate the utility of the preprocedural platelet-lymphocyte ratio (PLR) for predicting no reflow in patients undergoing primary percutaneous intervention (PCI) for the treatment of ST-segment elevation myocardial infarction. The thrombolysis in myocardial infarction (TIMI) flow grades of 287 patients treated with primary PCI were assessed retrospectively. Patients were divided into 3 tertiles based upon preprocedural PLR. Pre- and postprocedural TIMI flow grades were evaluated. No reflow developed in 6, 14, and 43 patients in the lower, middle, and higher tertiles, respectively (P < .001). After multivariate analysis, PLR remained a significant predictor of no reflow together with neutrophil-lymphocyte ratio (NLR). A cutoff value of 160 for PLR and 5.9 for NLR predicted no reflow with sensitivities and specificities of 75% and 71% and 74% and 70%, respectively. In conclusion, high preprocedural PLR and NLR levels are significant and independent predictors of no reflow in patients undergoing primary PCI.
