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    Gingival metastase and intracerebral haemorrhage resulting from unsuspected choriocarcinoma: A case report
    (2010) Tasdemir M.S.; Aktas A.; Tasdemir N.; Nergiz Y.
    Gestational choriocarcinoma is a higly malignant epithelial tumour arising from the trophoblasts of any type of gestational event, most often a hydatidiform mole. Choriocarcinoma is for all practical purposes limited to reproductive age women but rare examples of choriocarcinoma in postmenoupausal women have been reported. In case of a 24- years- old was a female patient with left hemiparalysis. Biopsy that obtained from lower gingival ulcer indicated the availability of choriocarcinoma metastasis. Before putting her in our intensive care unit she suddenly became unconscious. Focally haemorrhagic fragile gingival tissue (grossly, 1× 1× 0.5 cm) was processed. In the formaline fixed, paraffin embedded and hematoxylin and eosin(H&E) stained slides, beneath the stratified squamous epithelia, there was tumoral infiltration. Tumor was consisted of abnormal cytotrophoblasts and syncytiotrophoblasts cells and diffuse intercerebral haemorrhage. In this report we presented a rare case of metastatic gingival choriocarcinoma and intracranial haemorrhage resulting from an unsuspected choriocarcinoma metastasis.
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    The histological structure of filiform and fungiform papillae of the puppy rats which born from the rats given EGF after sialoadenectomy
    (2009) Aktas A.; Nergiz Y.
    After the complete removal of submandibular gland surgically, morphological alterations, and the effects of EGF given orally on these alterations were investigated. In the study, 30 adult female Spraque-Dawley rats were used, which were divided equally into three groups: Control group; sialoadenectomy group; sialoadenectomy + epidermal growth factor group. Following a three week period of recovery, the rats were mated. On days 16-19 th of pregnancy, a total of 5 microgram EGF was given to the animals in sialoadenectomy + epidermal growth factor group with orogastric tube as 1.25?g daily to each animal. The fetuses born following pregnancy were kept to grow up until the 28th day. The pupy rat of 28 days in all groups were taken, and then they were sacrificed. Tongues of all puppy rats were fixed in a 10 % neutral buffered formalin solution. The paraffin sections obtained through routine histological methods were stained with Hematoxylen-Eosine, Methylen blue- Basic Fuchsin, Hemotoxylen-Van Giesson, and were examined under light microscope. A significant increase in the keratinization; an elongation and bifurcation at the ends of the filiform papillae of the sialoadenectomy group rats were observed. The fungiform papilla and the taste buds were noticed to be larger than that of the control group, and a decrease was detected in the cells population that constitutes the taste buds. Bifurcation and hyperkeratosis in the filiform papillae of the sialoadenectomy + epidermal growth factor group rats.The morphological appearance of fungiform papillae and taste buds was observed to be similar to that of fungiform papillae of the control group.
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    Progressive external ophthalmoplegia (PEO): Presentation of a mitochondrial myopathy accompanied by electron microscope
    (2010) Aktas A.; Tasdemir M.S.; Tasdemir N.; Nergiz Y.
    Kearns-Sayre syndrome is a mitochondrial disease, presenting findings before the age of 20 and characterized by chronic progressive external ophthalmoplegia and pigmentary retinal degeneration. It affects many organs, resulting in a very wide spectrum of complications. In this work, a 24-year-old female, whose complaints first started at the age of 12, showing progressing external ophthalmoplegia and diagnosed with Kearns-Sayre disease following mitochondrial changes in muscle electron microscope investigation was presented. Ways of diagnosing in mitochondrial diseases, especially those in children were tried to be evaluated.