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    Decreased Serum Sulphydryl Levels as a Sign of Increased Oxidative Stress in Generalized Anxiety Disorder
    (Korean Neuropsychiatric Assoc, 2013) Kaya, Mehmet Cemal; Bez, Yasin; Karababa, Ibrahim Fatih; Emhan, Ali; Aksoy, Nurten; Bulut, Mahmut; Gunes, Mehmet
    Objective In recent years, many published studies have focused on the relationship between oxidative stress and psychiatric disorders. However, studies in generalized anxiety disorder (GAD) are few despite relatively high prevalence rates. In an attempt to fill this gap in the literature we aimed to measure serum levels of free sulphydryl, an important member of antioxidant defense mechanisms, of the patients with GAD. Methods A total of 35 (23 female, 12 male) GAD patients without any other co-morbid medical or psychiatric disorder and 35 (23 female, 12 male) healthy controls have been included in the study. Disease severity of the patients were quantified by using the Hamilton Anxiety Rating Scale (HAM-A). Serum free sulphydryl group levels of patients and healthy controls were measured in an appropriate way. Results Mean level of serum sulphydryl groups was significantly lower in the patient group. There was a negative correlation between their level and the disease duration. However, they did not show any significant correlation with the disease severity. Conclusion Decreased serum sulphydryl level observed in pure GAD patients suggests an increased oxidative stress in these patients. Well designed future researches are needed to replicate our findings and to test the implications of the present study.
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    Öğe
    Prolidase activity and oxidative status in patients with thalassemia major
    (Wiley, 2010) Çakmak, Alpay; Söker, Murat; Koç, Ahmet; Aksoy, Nurten; 0000-0001-8463-2723
    Aim: Prolidase is a specific imidodipepticlase involved in collagen degradation. The increase in the enzyme activity is believed to be correlated with the increased intensity of collagen degradation. The study aimed to evaluate the relationship between prolidase activity and oxidative status in patients with thalassemia major. Methods: Comparison was made between 87 patients diagnosed with thalassemia major and 33 healthy children of similar age and gender. Mean age of the subjects was 7.5 +/- 4.3 years in the group of patients with thalassemia major and 8.9 +/- 3.1 years in the control group. Serum prolidase activity was measured spectrophotometrically. Oxidative status was determined using total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) measurement. Results: Prolidase activity was significantly increased in patients with thalassemia major (53.7 +/- 8.7U/l) compared to the control group (49.2 +/- 7.2 U/l, P<0.001). TOS was significantly increased in the patient group (5.31 +/- 3.14 mmol H2O2 equiv./l) compared to the control group (3.49 +/- 2.98 mmol H2O2 equiv./l) and the OSI was also significantly increased in the patient group (3.86 +/- 3.28 arbitrary unit) compared to the control group (2.53 +/- 2.70 arbitrary unit) (P<0.0001 and P<0.001, respectively), while there were no significant differences between the patient (1.61 +/- 0.30 mu mol Trolox equiv./l) and control (1.64 +/- 0.33 mu mol Trolox equiv./l) groups with respect to TAC. Conclusion: Significant increases in prolidase activity in patients with thalassemia major may constitute a key parameter in demonstrating a disorder of the collagen metabolism.