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Öğe Clinical characteristics of gastrointestinal stromal tumors in southeast region of Turkey(Oxford Univ Press, 2006) Cil, Timucin; Altintas, Abdullah; Kaplan, Mehmet A.; Ayyildiz, Orhan; Sayar, Suleyman; Akgun, Yilmaz; Isikdogan, Abdurrahman[Abstract Not Available]Öğe Factors affecting mortality of Fournier's gangrene: Review of 70 patients(Wiley, 2007) Ersay, Ahmet; Yilmaz, Gulsen; Akgun, Yilmaz; Celik, YusufBackground: Fournier's disease is a potentially fatal, acute, gangrenous infection of the scrotum, penis or perineum associated with a synergistic bacterial infection of the subcutaneous fat and superficial fascia. Methods: The clinical records of 70 patients treated for Fournier's gangrene were evaluated retrospectively to determine prognostic indices and to stress Fournier's Severity Index (FSI), influencing outcome. Results: The mortality rate in this study was 22.8%. Length of the hospitalization time and FSI were detected as effective factors on mortality of Fournier's gangrene (P < 0.05) by Binary Logistic Regression analysis and the area under the receiver operating characteristic curve of these variables was also found to be significant (P < 0.001). The average FSI was determined as 4.66 +/- 2.31 in survivors and 11.56 +/- 2.68 in non-survivors and 5.11 +/- 2.83 in patients with primary genito-urinary infection but 7.56 +/- 4.35 in primary anorectal infection. The FSI was also found predictive of hospitalization time and number of debridements among survivors. Conclusion: Fournier's Severity Index is a simplified way of comparing patients with this disease and may also have some significance in predicting outcome. The FSI is a more significant and predictive tool that should be popularized to predict the prognosis in Fournier's gangrene.Öğe Intussusception in adults(Turkish Assoc Trauma Emergency Surgery, 2009) Korkmaz, Oezguer; Yilmaz, Hatice Guelsen; Tacyildiz, Ibrahim Halil; Akgun, YilmazBACKGROUND Adult intussusception is an unusual entity, and its etiology differs from that in pediatric patients. The purpose of this study was to determine the causes and management of intussusception in adults. METHODS A retrospective review of patients with a diagnosis of gastrointestinal intussusception between 1986 and 2006 was conducted. All patients under the age of 18 and cases with rectal, ostomy, or gastroenterostomy prolapse were excluded. RESULTS There were 28 cases of adult intussusception. Mean age was 38.6 +/- 16.7 years. A preoperative diagnosis of intussusception was made in 53.5% of the cases. There were 23 enteric, three colonic and two ileocolic intussusceptions. A lead point was identified in 25 patients (89.3%). Invagination was due to benign causes in 19 patients, malignant causes in six patients and idiopathic in three patients. Complication was seen in three (10.3%) cases. CONCLUSION In this series, the mean age of the patients was younger than in the literature. Since intussusception was due to small bowel pathologies, the proportion of benign/malignant lesions favored benign lesions. Although it is encountered rarely in adults, physicians should be aware of invagination and consider it in each case of acute abdomen because of the wide spectrum of the clinical settings.Öğe L-carnitine has a protective effect on the colonic mucosa during abdominopelvic radiotherapy in rats(Acta Cirurgica Brasileira, 2016) Tas, Sukru; Ozkan, Omer Faruk; Cikman, Oztekin; Kiraz, Asli; Akgun, Yilmaz; Karaayvaz, MuammerPURPOSE: To evaluate histopathologically the radioprotective effect of L-carnitine on the colonic mucosa in rats undergoing abdominopelvic irradiation. METHODS: Thirty-two rats were randomly assigned to four experimental groups: intraperitoneal administration of normal saline (group 1) or L-carnitine (300 mL/kg; group 2), followed in groups 3 and 4, respectively, by one dose of abdominopelvic radiation (20 Gy) 30 min later. Rats were sacrificed 5 days after radiation, and their descending colons were resected for histopathological evaluation of the presence and severity of damage. RESULTS: Average damage scores did not differ significantly between groups 1 and 2 (0.13 +/- 0.35 and 0.25 +/- 0.46, respectively); the group 3 score was highest (10.25 +/- 0.71), and the group 4 score (3.63 +/- 1.41) was significantly lower than that of group 3 (both p = 0.0001). Pre-radiation L-carnitine administration significantly reduced mucosal thinning, crypt distortion, reactive atypia, inflammation, cryptitis, and reactive lymph-node hyperplasia (all p < 0.01). CONCLUSIONS: L-carnitine had a radioprotective effect on rat colonic mucosa. L-carnitine use should be explored for patients with gastrointestinal cancer, who have reduced serum L-carnitine levels.Öğe SCHWANNOMA OF THE BREAST: REPORT OF A CASE(Aves, 2007) Korkmaz, Ozgur; Yilmaz, Hatice Gulsen; Ozekinci, Selver; Tacyildiz, Ibrahim Halil; Akgun, YilmazSchwannoma is a slow-growing tumor that frequently occurs in the extremities, the trunk and the head region. We report a case of benign schwannoma of the breast in a 76-year-old woman. The palpable mass was localized in the upper outer quadrant of the right breast. Complete excision of the mass was done and pathology revealed a schwannoma.Öğe An unusual etiology for adult intussusception: post-vagotomy jejunojejunal invagination(Turkish Soc Gastroenterology, 2010) Korkmaz, Ozgur; Kece, Can; Yilmaz, Hatice Gulsen; Akgun, Yilmaz[Abstract Not Available]