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Öğe Acute hemorrhagic edema of infancy(Dicle Üniversitesi Tıp Fakültesi, 2009) Menteş, Sultan Ecer; Taşkesen, Mustafa; Katar, Selahattin; Günel, M. Emin; Akdeniz, SedatAcute hemorrhagic edema of infancy is a rare form of leukocytoclastic vasculitis. Mostly it appears under three years of age and is characterized by purpuric skin lesions, fever and edema. A three years-old boy, who has cough and coryzea was admitted to our clinic for fever and red spots on legs and arms. In physical examination; ecimotic skin lesions on right ear, face, arms, dorsal of the hands, buttocks, legs and dorsal of the feet were found. In the laboratory tests acute phase reactants were elevated and blood coagulation tests were in normal range. Hepatit A,B,C and TORCH markers were negative. Punch biopsy obtained from gluteal area showed leukositoclastic vasculity. Focal fibrinogen accumulation was detected by immun fluorescent microscopy. Regression on lesions was not observed despite supportive therapy, so prednisolone (1 mg/kg/day) therapy was started. On the third day of the steroid therapy, complete recovery was achived.Öğe Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree(Turkish J Pediatrics, 2017) Yildirim, Tuba Talo; Kaya, Filiz Acun; Taskesen, Mustafa; Dundar, Serkan; Bozoglan, Alihan; Tekin, Gulucag Giray; Akdeniz, SedatKindler syndrome (KS) is a rare genetic disorder. The clinical features include aggressive periodontal disease and severe desquamative gingivitis. Five individuals with KS were assessed by oral examination, radiographic analysis and periodontal measurements. All the patients' indexes were recorded prior to periodontal treatment and at the end of the 1th, 3th, 6th, 9th and 12th month respectively. All the patients had improvement of periodontal status and enhancement in index scores. The affected individuals were previously screened for FERMT1 mutations. KS patients' periodontal disease activity could be taken under control with regular follow-up.Öğe Aksiller hiperhidroz tedavisinde botulinum toksini: Bir olgu sunumu(2000) Alp, Semahat; Çetin, Hilal; Akdeniz, Sedat; Harman, MehmetLokalize idiopatik hiperhidroz nedeni bilinmeyen bir terleme hastalığıdır. Klasik tedaviler eksiksiz ise; sempatektomi ve aktif ter bezlerinin çıkartılması gibi cerrahi tedaviler alternatif tedavilerdir. Botulinum toksininin terlemeyi azalttığını bildiren çalışmalar vardır. Botulinum toksini ile etkin bir şekilde tedavi edilen bir olguyu sunuyoruz.Öğe Anesthesia dolorosa caused by penetrating cranial injury(Karger, 2006) Tatli, Mehmet; Keklikci, Ugur; Aluclu, Ufuk; Akdeniz, SedatAnesthesia dolorosa (AD) is an uncommon complication of surgical treatments for trigeminal neuralgia. Its incidence is around 0.8%. To our best knowledge, AD caused by a penetrating cranial injury has not been reported previously. We report the case of a 31-year-old male patient with left-sided neuropathic keratitis and AD that began 18 years earlier, following a penetrating cranial injury with a knife to the left postauricular area. The patient was successfully treated by a carbamazepine and gabapentin combination. In conclusion, penetrating cranial injury is uncommon but may cause a serious neurologic disturbance. In the differential diagnosis of AD, a penetrating injury should be kept in mind. In these cases, treatments should be effective and immediate; otherwise, this may result in catastrophic consequences such as neurotrophic keratitis and blindness. Ophthalmologists should be aware of these potential problems. Copyright (c) 2006 S. Karger AG, Basel.Öğe A brownish-red plaque in an adult(Medknow Publications, 2009) Harman, Mehmet; Akdeniz, Sedat; Balci, Goekcen; Uzunlar, Ali Kemal[Abstract Not Available]Öğe A Case with Lipoid Proteinosis Intersected with Diabetes Mellitus(Galenos Yayincilik, 2009) Gokalp, Deniz; Tuzcu, Alpaslan; Bahceci, Mithat; Yildirm, Muzeyyen; Akdeniz, Sedat; Ozekinci, Selver; Urakci, ZuhatLipoid proteinosis (LP) is a rare disorder inherited as an autosomal recessive trait. LP is characterized by deposition of hyaline-like material in the skin, mucous membranes, and other tissues. LP has been mapped to chromosome 1q21, the locus for the extracellular matrix protein 1 (ECM1) gene. In this case report, we aimed to present a case with LP accompanied by diabetes mellitus, and to discuss the possible mechanisms of diabetes in LP. A 16-year-old girl presented to the endocrinology department with hyperglycemia. She reported a history of progressive hoarseness of her voice since she was two years old. Our patient meets the clinical and histopathological criteria for the diagnosis of LP. Her fasting glucose was 310 mg/dl. Plasma insulin and C-peptide levels were 5.1 uU/ml and 1.57 ng/ml, respectively. Hemoglobin A1c was 12.3%. HOMA-IR (Homeostasis Model Assessment-Insulin Resistance) ratio was 3.1 (normal range <3.7). Serum islet cell antibodies, anti-GAD antibodies and anti-insulin antibodies were negative. Diabetes mellitus was diagnosed and insulin treatment was initiated. In conclusion, possible mechanism of diabetes mellitus may be result of the diffuse deposition of amorphous material into the capillary vessels or in pancreas. The other possible mechanism responsible for the association of diabetes mellitus and insulin resistance in LP patients may be sharing a mutation at 1q21 locus. Future studies which aimed screening of insulin resistance and diabetes mellitus in LP patients may be helpful to explain this association.Öğe Colchicine may be of therapeutic benefit in prurigo pigmentosa(Wiley, 2018) An, Isa; Ucmak, Derya; Ibiloglu, Ibrahim; Demir, Vasfiye; Akdeniz, SedatPrurigo pigmentosa (PP) is a rare inflammatory skin disease. Neutrophil-mediated inflammation is considered to be responsible for the etiopathogenesis of PP. We consider that colchicine may be an effective agent in the treatment of PP since it exerts an antiinflammatory effect by inhibiting neutrophil chemotaxis. Further studies are required to verify whether colchicine is an effective treatment option for PP.Öğe Cryoglobulin and antineutrophil cytoplasmic antibody positive cutaneous vasculitis due to propylthiouracil(Wolters Kluwer Medknow Publications, 2014) Akkurt, Zeynep Meltem; Ucmak, Derya; Acar, Gurbet; Beysel, Selvihan; Turkcu, Gul; Ucak, Haydar; Akdeniz, Sedat[Abstract Not Available]Öğe Effect of acitretin on recalcitrant warts(1998) Aytekin, Sema; İnalöz, H. Serhat; Civaş, Ekrem; Akdeniz, Sedat; Harman, MehmetThe efficacy of acitretin treatment was evaluated in 2 patients with multiple recalcitrant warts and psoriatic erythroderma. The daily dose of acitretin was initially 50 mg per day, orally. In both patients the warts impressively regressed during the treatment. Almost complete resolution was achieved after 3 months of acitretin therapy, but the termination of the treatment resulted in a total relapse within the following 12 weeks.Öğe Fixed drug eruption probably induced by azithromycin(Wiley, 2017) An, Isa; Demir, Vasfiye; Akdeniz, Sedat[Abstract Not Available]Öğe Infantile iatrogenic Cushing's syndrome(2008) Katar, Selahattin; Akdeniz, Sedat; Özbek, Mehmet Nuri; Yaramış, AhmetHigh potency or/and extended use of topical corticosteroids, particularly in children, may cause suppression of the hypothalamopituitary-adrenal axis. However, iatrogenic Cushing's syndrome in infantile age group is very rare and only a few patients have been reported to date in the literature. Here, we report a case of iatrogenic Cushing's syndrome in a 6-month-old male child whose parents have admitted to the hospital for overweight and skin fragility.Öğe Keratoacanthoma associated with lichen planus(Saudi Med J, 2007) Akdeniz, Sedat; Harman, Mehmet; Buyukbayram, Huseyin[Abstract Not Available]Öğe Kindler syndrome: A focal adhesion genodermatosis(2009) Lai-Cheong, Jelai E.; Tanaka, Akio; Hawche, G.; Emanuel, Patrick O.M.; Maari, Catherine H.; Taşkesen, Mustafa; Akdeniz, SedatKindler syndrome (OMIM 173650) is an autosomal recessive genodermatosis characterized by trauma-induced blistering, poikiloderma, skin atrophy, mucosal inflammation and varying degrees of photosensitivity. Although Kindler syndrome is classified as a subtype of epidermolysis bullosa, it has distinct clinicopathological and molecular abnormalities. The molecular pathology of Kindler syndrome involves loss-of-function mutations in a newly recognized actin cytoskeleton-associated protein, now known as fermitin family homologue 1, encoded by the gene FERMT1. This protein mediates anchorage between the actin cytoskeleton and the extracellular matrix via focal adhesions, and thus the structural pathology differs from other forms of epidermolysis bullosa in which there is a disruption of the keratin intermediate filament-hemidesmosome network and the extracellular matrix. In the skin, fermitin family homologue 1 is mainly expressed in basal keratinocytes and binds to the cytoplasmic tails of ?1 and ?3 integrins as well as to fermitin family homologue 2 and filamin-binding LIM protein 1. It also plays a crucial role in keratinocyte migration, proliferation and adhesion. In this report, we review the clinical, cellular and molecular pathology of Kindler syndrome and discuss the role of fermitin family homologue 1 in keratinocyte biology.Öğe Kyrle's disease in diabetes mellitus and chronic renal failure [4](1998) Harman, Mehmet; Aytekin, Sema; Akdeniz, Sedat; Derici, M.[No abstract available]Öğe Lansoprazole-Induced Subacute Cutaneous Lupus Erythematosus(Turkish League Against Rheumatism, 2017) An, Isa; Demir, Vasfiye; Ibiloglu, Ibrahim; Akdeniz, Sedat; Ucmak, Derya[Abstract Not Available]Öğe Lichenoid drug eruption induced by colchicine: case report(Taylor & Francis Ltd, 2017) An, Isa; Demir, Vasfiye; Akdeniz, SedatLichenoid drug eruption (LDE) is a common cutaneous side effect of drugs including antimalarials, antihypertensives, nonsteroids, anti-inflammatory drugs and diuretics. The physiopathologic relationship between colchicine treatment and LDE is unclear. There is very little documentation of LDE induced by colchicine in the literature. In this report, we present a case that developed LDE on the abdomen and the legs during the colchicine treatment.Öğe Malaria status in diyarbakir and its districts between 1995–2000 years on basis of the malaria eradication institute's data(2005) Suay, Adnan; Mete, Mahmut; Kaya, N. A.; Akdeniz, SedatThe records for malarial patients were detected by malaria surveillance studies and by research of Malaria Eradication Instıtute, Diyarbakır branch between the years of 1995 - 2000 were examined in this study. According to the records, a total of 751.312 blood samples were investigated for active surveillance, passive surveillance and check studies and a total of 80.330 malaria cases were detected. All the cases were Malaria tertiana caused by Plasmodium vivax. Of the malarial donors, 44.033 were male (54.8%) and 36.297 were female (45.2 %). According to the years in which the experimental data were collected, the number of cases, which was 26.912 in 1995, fell down to 2.581 in 2000. In the total, July, in which 12.361 symptoms were detected, and August, in which 10.572 symptoms were found were the months in which the highest numbers were seen. In addition, the most prevalent age groups for malaria infection were 15 - 24 years-old with 17.387 patienst, and 25 - 44 years-old with 17.757 patients. Furthermore, Ergani with 10.686 and Silvan with 13.774 symptoms occupied the first places for the intensity of infection.Öğe Meme başı ve areolanın nevoid hiperkeratozu: Olgu sunumu(2001) Akdeniz, Sedat; Kılınç, Nihal; Yaldız, Mehmet; Özekinci, Selver; Yılmaz, Fahri[Abstract Not Available]Öğe Occupational skin diseases in automotive industry workers(Taylor & Francis Ltd, 2014) Yakut, Yunus; Ucmak, Derya; Akkurt, Zeynep Meltem; Akdeniz, Sedat; Palanci, Yilmaz; Sula, BilalAim: To investigate the prevalence of occupational skin diseases in workers of the automotive industry. Materials and methods: Between September and December 2011, a total of 405 workers from the automotive repair industry in Diyarbakir were interviewed. They were active workers in the repair industry who had been employed for at least six months. Business owners, sellers of spare parts and accounting officers were not included. The employees were examined at their workplaces and the working conditions were observed. Detailed dermatological examination was performed. Results: The mean age of the 405 workers who participated in the study was 27.7 +/- 10.3. The mean working time of employees was 13.3 +/- 10.4 years. All of the employees were male. Dermatological diseases were not detected in 144 out of 405 workers (35.6%) and at least one condition was diagnosed in 261 (64.4%). The most frequent diagnosis was callus, hyperkeratosis, clavus (27.7%), followed by nail changes (16.8%) and superficial mycoses (12.1%). Contact dermatitis was seen at a rate of 5.9%. Discussion: Traumatic lesions such as hyperkeratotic lesions and nail changes were found most frequently. Traumatic lesions were common among individuals who did not use gloves. Most nail changes were localized leuconychia, a finding not reported in the studies on automotive industry workers. In accordance with the literature, irritant contact dermatitis was observed in patients with a history of atopy and who had been working for a long time. Conclusion: Occupational skin diseases comprise an important field in dermatology, deserving much attention. Further studies on occupational dermatology are necessary.Öğe Ophthalmic Manifestations in Patients with Ectodermal Dysplasia Syndromes(Wroclaw Medical Univ, 2014) Keklikci, Ugur; Yavuz, Izzet; Tunik, Selcuk; Ulku, Zelal Baskan; Akdeniz, SedatBackground. Ectodermal dysplasia (ED) is a disorder that results from abnormal formation of at least two of the four major ectodermal derivatives in the developing embryo. The ectoderm of the embryo forms the skin, teeth, hair and nails, sweat glands and part of the eyes. Objectives. The aim of this article is to reveal ophthalmologic symptoms and signs as multidisciplinary, reliable criteria for ectodermal dysplasia. Material and Methods. In this retrospective study, 24 patients with ED were analyzed from the recorded data. Ophthalmological examination of the patients, who had previously received the diagnosis of ED in the dental department, was done. During the examination, ocular symptoms related to tear film, corneal changes, lacrimal duct, periorbital hyperpigmentation, alteration lashes and eyebrows were evaluated. Results. The age ranged between 3-45, and the mean and standard deviation (Mean +/- SD) was 15.8 +/- 7.4 years. The number of males was 13 (54.2%) and females, 11(45.8%). Eighteen patients (75.0%) suffered from ocular complaints related to the ocular surface. In 11 of the patients with ED, there were dry eye symptoms. While the mean age of cases with eye involvement was 17.5, it was 23.1 in cases with dry eye symptoms. Conclusions. In the study, it was observed that, in patients with ED, ocular complaints, particularly dry eye symptoms, may increase as age advances.
