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Öğe Determining quality of life and associated factors in patients with stroke(Turkish Society of Physical Medicine and Rehabilitation, 2015) Em, Serda; Bozkurt, Mehtap; Karakoç, Mehmet; Çağlayan, Mehmet; Akdeniz, Dicle; Oktayoğlu, Pelin; Varol, Sefer; Nas, KemalObjective: This study aims to examine the overall and domain-specific quality of life in patients with stroke and to identify variables predicting quality of life after stroke. Material and Methods: A total of 104 patients with sufficient cognitive functions having hemiplegia because of cerebrovascular accident and 108 controls were included in this study. Demographic and clinical features were recorded. The Barthel Index (BI) and Functional Ambulation Category scale were employed to assess the functional state of patients. Quality of life was evaluated by the Short Form 36 (SF-36) health survey, whereas the emotional state of the patients was evaluated by the Hospital Anxiety and Depression Scale (HADS). Functional status, motor impairment, and emotional state were determined as independent variables, and multiple regression analysis was used to predict quality of life. Results: Patients had significantly lower scores in the quality of life subscores and total scores in comparison with the controls (p<0.001). The mean anxiety and depression rates in the patients were significantly higher than those in controls (p<0.001). The sum of subscores and physical composite score of SF-36 were significantly lower in female and illiterate patients than in male and educated patients. Multiple regression analyses indicated that HADS depression was associated with mental health (p<0.001), whereas BI was independently associated with the physical health total score (p<0.05). The power of the statistical analysis for study population was 100% according to the given effect size (α=0.01). Conclusion: Present results demonstrated that patients with stroke have a significantly poor quality of life than the general population. The reduced quality of life after stroke appears to be related the emotional state, physical disability, and demographic properties such as gender and education. Therefore, prevention of disability and early diagnosis and treatment of depression are vital in improving the quality of life of patients with stroke.Öğe İnmeli hastalarda uyku kalitesi ve ilişkili faktörlerin değerlendirilmesi(Fırat Üniversitesi Tıp Fakültesi, 2015) Akdeniz, Dicle; Em, Serda; Çağlayan, Mehmet; Bozkurt, Mehtap; Oktayoğlu, Pelin; Karakoç, Mehmet; Nas, KemalAmaç: Bu çalışmanın amacı inmeli hastalarda uyku kalitesini değerlendirmek; uyku kalitesi üzerine fonksiyonel durum, emosyonel durum ve motor iyileşmenin etkisini belirlemektir. Gereç ve Yöntem: Serebrovasküler olaya bağlı inmesi olan 62 hasta ve 62 sağlıklı gönüllü çalışmaya alındı. Çalışma grubunun sosyodemografik verileri ve hastaların klinik bulguları kaydedildi. Fonksiyonel durumu değerlendirmek için Barthel İndeksi (Bİ) ve Fonksiyonel Ambulasyon Sınıflaması kullanıldı. Uyku kalitesi Pittsburgh Uyku Kalitesi indeksi (PUKİ) ile değerlendirilirken, emosyonel durum Hastane Anksiyete Depresyon Ölçeği (HADÖ) ile belirlendi. Fonksiyonel durum, motor bozukluk ve emosyonel durum bağımsız değişkenler olarak alındı ve multipl regresyon analizi uyku kalitesini tahmin etmek için kullanıldı. Bulgular: Hastalarda PUKİ’nin tüm alt skorları ve total skoru kontrol grubuna göre anlamlı olarak yüksekti (p<0.001). Total PUKİ skoru ile HADÖ anksiyete ve depresyon skoru korele idi (p<0.01). Bİ ile PUKİ total skoru arasında da anlamlı negatif korelasyon vardı. Multipl regresyon analizi HADÖ depresyon duygu durumunun uyku kalitesini tahmin etmede en önemli faktör olduğunu gösterdi (p<0.01). Sonuç: Çalışmamız kontrol grubuna göre inme hastalarının uyku kalitesinde bozulma olduğunu gösterdi. Aynı zamanda hastaların emosyonel durumları ve fiziksel disabiliteleri ile uyku kalitesi de ilişkiliydi. Çalışmamıza göre depresyon uyku kalitesini belirleyen en önemli faktör olduğu için özellikle depresyonun erken tanı ve tedavisi ile inmeli hastaların uyku kalitesinin artacağını düşünmekteyiz.Öğe İnmeli hastalarda uyku kalitesinin hastalığın klinik parametreleri, psikolojik durum ve yaşam kalitesi ile ilişkisi(2015) Akdeniz, DicleGiriş ve amaç: İnme, serebral kan damarlarının tıkanması veya rüptürü sonucu ani nörolojik bulgu oluşturan travmatik olmayan beyin hasarıdır. İnme hastalarında uyku kalitesi ve bununla ilişkili olarak yaşam kalitesi etkilenmektedir. Bu çalışmanın amacı inmenin uyku kalitesi üzerindeki etkisini belirlemek; uyku kalitesi ile klinik parametreler, yaşam kalitesi ve psikolojik durum arasındaki ilişkiyi ortaya koymaktır. Materyal ve metod: Çalışmaya 52 inme hastası ve 54 sağlıklı kontrol dahil edildi. Çalışma grubunun demografik özellikleri ve inmeye bağlı klinik bulguları kaydedildi. Hasta grubu Ashworth spastisite evrelemesi, Brunnstrom fonksiyonel evrelemesi, Barthel indexi ve Fonksiyonel ambulasyon skalası (FAS) na göre değerlendirildi. Çalışma grubunun emosyonel durumu Hastane Anksiyete-Depresyon Ölçeği (HADÖ) ile, yaşam kalitesi kısa form-36 (SF-36) ile değerlendiridi. Hastaların uyku kalitesini değerlendirmek için Pittsburgh uyku kalitesi indeksi (PUKİ) ölçeği uygulandı. Bulgular: İnmeli hastalarda, öznel uyku kalitesi, uykuya dalma süresi, alışılmış uyku etkinliği, uyku bozukluğu, uyku ilacı kullanımı, gündüz işlev bozukluğu, ve total PUKİ skoru kontrol grubuna göre anlamlı olarak yüksekti (p < 0,05). Sonuçlar: İnmeli hastalarda uyku kalitesi bozulmuştur ve bu durum depresyon, anksiyete, fonksiyonel durum ve spastisite düzeyi ile ilişkilidir. Anahtar kelimeler: inme, uyku kalitesi, yaşam kalitesi, psikolojik durum, fonksiyonel durumÖğe Serum cytokine levels in Behçet's disease(Wiley, 2015) Akkurt, Zeynep Meltem; Bozkurt, Mehtap; Uçmak, Derya; Yüksel, Hatice; Uçak, Haydar; Sula, Bilal; Özkurt, Zeynep Gürsel; Yıldız, Mehmet; Akdeniz, Dicle; Arıca, Mustafa; 0000-0003-3742-6075BackgroundThe aim of this study is to investigate and compare the serum levels of various cytokines in patients with Behcet's Disease and healthy controls. MethodsThirty-five patients with Behcet's disease and 29 age and sex-matched healthy controls were included in the study. The patients were separated into groups with active and inactive disease. Serum IL-2, IL-6, IL-8, IL-10, IL-17A, and IFN- levels were determined using the enzyme-linked immunosorbent assay method. Cytokine levels of the two patient groups and healthy controls were compared using SPSS 15.0. ResultsTen patients with active disease and 25 patients with inactive disease were present. Serum IL-8 levels of active BD patients were higher compared to inactive patients (P = 0.048) and healthy controls (P = 0.02). IL-8 levels were correlated with the duration of symptoms (r = 0.490, P = 0.003) and time passed since diagnosis (r = 0.579, P ? 0.001). ConclusionBehcet's disease involves complex interactions of cells of the immune system, mainly T lymphocytes and neutrophils. Further studies on the cytokine profile in Behcet's disease will aid in elucidation of its pathogenesis.Öğe Serum prolidase enzyme activity and oxidative status in patients with Behçet's disease(Taylor and Francis, 2014) Bozkurt, Mehtap; Yüksel, Hatice; Em, Serda; Oktayoğlu, Pelin; Yıldız, Mehmet; Akdeniz, Dicle; Nas, KemalObjectives: To assess serum prolidase enzyme activity and oxidative stress in patients with Behçet's disease (BD). Methods: The study population consisted of BD patients (n = 42) and healthy participants (n = 29). BD patients were classified as active (n = 18) or inactive (n = 24) according to disease activity. Serum prolidase enzyme activity, total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and malondialdehyde (MDA) levels were measured. Results: In BD patients with active disease, serum prolidase activity was significantly higher compared with the inactive and control participants. Serum prolidase activity was also significantly higher in all BD patients in comparison with controls. Serum prolidase activity was also positively correlated with OSI, C-reactive protein, and active BD. MDA, TOS, and OSI levels were all significantly higher in the BD group when compared with the healthy control participants. Serum TAS levels were significantly lower in BD patients in comparison with healthy controls. Conclusion: High prolidase activity may indicate critical biological activities relevant to pathological events in BD, and this activity may be a biological indicator of disease. Further studies are needed to verify these findings.Öğe Sleep quality in patients with Behcet's disease(Wiley, 2017) Yazmalar, Levent; Batmaz, Ibrahim; Sariyildiz, Mustafa A.; Yildiz, Mehmet; Ucmak, Derya; Turkcu, Fatih; Akdeniz, DicleAimThe aim of this study was to evaluate sleep quality and the related variables in patients with Behcet's disease (BD). MethodOne hundred and twelve patients diagnosed with BD and 67 age- and gender-matched healthy controls were enrolled in the study. The Pittsburgh Sleep Quality Index (PSQI) was used for the evaluation of sleep disturbance in all participants. The quality of life (QoL) of all patients were evaluated by Nottingham Health Profile (NHP), and anxiety and depression which were assessed by Hospital Anxiety and Depression Scale (HADS). ResultsThe patients with BD had significantly higher scores in subjective sleep quality, sleep latency, sleep efficiency, sleep disorder, functional disorder in the morning and total PSQI score compared to the healthy control group. According to Pearson's analysis, there was a significantly higher correlation between the anxiety, depression and all components of NHP scores and the total PSQI score. Logistic regression analyses indicated that genital ulcer and arthritis were predictors for poor sleep quality. ConclusionSleep quality is disturbed in patients with BD. The lower quality of sleep is greatly associated with anxiety, depression, QoL, genital ulcers and arthritis.
