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Öğe The determination of qualities in different whole-plant silages among hybrid maize cultivars(Academic Journals, 2011) Demirel, Ramazan; Akdemir, Fatih; Saruhan, Veysel; Demirel, Dilek Senturk; Akinci, Cuma; Aydin, FiratThis study was conducted in order to determine the effects of 12 maize hybrids (Goldeclat, Falkner, Maverik, Tivak 6661, Tivak 678, Bora, Consur, DK 626, Ada 9510, Pioneer 3167, TTM 815, and LG 55) on the nutrient composition (that is, dry matter - DM, crude ash - CA, organic matter - OM, crude protein - CP, ether extract - EE, crude fiber - CF), pH, Fleig point (FP) values, and the mineral contents of maize silages. The maize hybrids were harvested at the milk-line maturity stage and ensiled as whole plant in 5-L plastic jars without additives. The jars were stored at 25 +/- 2 degrees C under standard laboratory conditions. the silages were uncovered and sampled for chemical analyses 60 days after they were ensilaged. There were statistically significant differences among maize hybrid silages for DM, CA, OM, CP, EE, CF contents, pH, and FP values (P<0.05). The DM content of silages were ranged from 25.67% in LG 55 to 32.41% in Falkner; CP (4.07% in Bora and LG 55 to 6.91% in Tivak 678); CA (4.64% in Maverik to 7.94% in LG 55); OM (17.07% in LG 55 to 27.64% in Falkner); EE (2.68% in DK 626 to 4.40% in Tivak 678); CF (17.96% in Pioneer 3167 to 27.28% in TTM 815); pH value (3.76 in TTM 815 to 4.05 in Pioneer 3167); FP (95.68 in LG 55 to 112.64 in Consur). The result of the study indicated that fermentation characteristics and nutrient contents were affected by the hybrids that were studied. However, there were no significant differences among dry matter mineral contents for As, B, Cr, Fe, Sn, Cu, Mn, and Zn (P>0.05); but there were significant differences among hybrids for Al (P<0.05).Öğe Dietary coenzyme Q10 may improve the growth performance and antioxidant status in quails exposed to cold stress(Polish Academy of Science, 2020) Bayril, Tahir; Akdemir, Fatih; Akşıt, Hasan Z.; Akşit, DilekIn this study, the effects of coenzyme Q10 (CoQ10) on growth performance, antioxidant status and organ weights in cold-stressed Japanese quails (Coturnix coturnix japonica) were investigated. During the experiment, a 2 × 3 factorial design was employed with two environmental temperatures (ET) and three levels of CoQ10 (0, 20 and 40 mg/kg). A total of 180 one-dayold male quails were randomly allocated into 6 groups with 6 replicates with 5 birds in each replicate. The birds were fed in two separate rooms at either 22 ± 2 °C for 24 h/day (thermoneutral, TN) or 12 ± 2 °C for 8 h/day (cold stress, CS; between 09:00 17:00) followed by 22 ± 2 °C for 16 h/day. CoQ10 addition into diet increased final body weight, body weight gain and cumulative feed intake only in CS regardless of the used dose. It was stated that CoQ10 supplementation did not exert influence on serum and liver superoxide dismutase (SOD) activity and liver total antioxidant status (TAS) in TN conditions, but increased these parameters in CS; however in liver the higher CoQ10 dose was required to obtain the statistically positive effect. When quails were exposed to CS a higher dose of CoQ10 caused a more pronounced decreased in serum malondialdehyde (MDA) level than the lower one; however the effect of CoQ10 on liver MDA level was shown regardless of the used dose. The obtained results show that CoQ10 supplementation reverses the negative effects of CS on growth performance, antioxidant status and organ weights in quails. The caused may effects partly associated with direct antioxidant properties of CoQ10 as well as the synergistic efficacy of CoQ10 with SOD activityÖğe The effect of dietary colostrum powder on performance, carcass yields and serum lipid peroxidation levels in Japanese quails (Coturnix coturnix Japonica)(Taylor and Francis Ltd., 2018) Akdemir, Fatih; Bayril, Tahir; Baran, Murat Sedat; Yıldız, Ahmet ŞenerColostrum is a nutrient-dense fluid secreted by female mammals for the first few days following birth. Colostrum can be supplemented to poultry diets as a feed additive due to its nutritious and performance-enhancing properties. This study was conducted to determine the effect of dietary colostrum powder (CL-P, Alpha Lipid Lifeline Colostrum, New Zealand) on growing performance, carcass weight and yield, organ weights, serum vitamins and malondialdehyde (MDA) levels in quails (Coturnix coturnix japonica). A total of 90 birds, one day old, were divided into 3 groups consisting of 6 replicate cages, 5 birds per cage. Birds were randomly fed on one of three diets: basal diet and basal diet supplemented with 2.5% or 5% of CL-P. At the end of the period of 42 days, CL-P supplementation increased final body weight (P <. 0001), weight gain (P <. 0001), feed intake (P =. 03), feed efficiency (P <. 0001), carcass weight (P <. 0001) and carcass yield (P <. 01). Amounts of serum MDA (P <. 001) levels also increased with increasing supplemental CL-P. As a result, growth performance can be improved and serum lipid peroxidation can effectively be attenuated by dietary CL-P supplementation at 5% of diets in Japanese quail.Öğe Effect of dietary stevia and ginger extracts on laying performance, fertility, hatchability, and serum biochemical parameters in laying Japanese quails exposed to heat stress(Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Science, 2023) Bayrıl, Tahir; Akdemir, Fatih; Orhan, Cemal; Gürgöze, SemaThe aim of this study was to determine the effect of various levels of supplemental stevia and ginger extracts (SGE) on laying performance, fertility, hatchability, and serum biochemical parameters in laying Japanese quails exposed to heat stress. SGE doses were added at the following levels: 0 (control), 0.5 (T1), 1.0 (T2), and 1.5% (T3) of the diet. In SGE-supplemented quails, feed intake (P < 0.0001), egg production (P < 0.0001), and egg weight (P < 0.002) were significantly the highest in the treatment groups (days 1–90). Feed conversion ratio (P < 0.0001) was lower in the treatment groups compared to the control group. The fertility index was higher in all experimental groups (P < 0.05). The weights of hatching eggs were higher in groups T2 and T3 (P < 0.0001). Egg weight in the laying period was higher in the 2nd month in control and group T1, and in the 2nd and 3rd month in groups T2 and T3 (P < 0.0001; P < 0.05). Hatched chick weights were higher in groups T2 and T3 (P < 0.0001). Serum aspartate aminotransferase levels in quails of group T3 were significantly lower than in the other groups (P < 0.01). Serum glucose and cholesterol levels were the lowest in groups T2 and T3 (P < 0.05). Serum triiodothyronine levels in the treatment groups were significantly lower (P < 0.01). In conclusion, these results suggested that dietary SGE improved laying performance, fertility, and hatchability, as well as mitigated the negative effects of heat stress on selected biochemical parameters in quails exposed to high environmental temperature.Öğe Effect of supplementary liquid colostrum on growth performance, carcass yield, ceruloplasmin, sialic acid and some antioxidant levels in quails(Kafkas Üniversitesi Veteriner Fakültesi, 2017) Baran, Murat Sedat; Bayrıl, Tahir; Akdemir, Fatih; Akşit, Hasan; Kahraman, MücahitThis study was conducted to determine the effects of supplementary liquid-colostrum (LiqC) on growth performance, carcass yield, ceruloplasmin, sialic acid, and antioxidant levels in growing quails. In this study, a total of 90 ten-days-old mixed-sexed Japanese quail chicks were used. Quails were divided randomly into 3 groups. Chicks were fed one of three diets: basal diet or basal diet supplemented with 2% or 4% liquid colostrum. Birds were exposed to a 14L:10D illumination cycle for 32 days. When the effects of dietary liquid colostrum supplementation on performance were examined, values of final body weight, live weight gain, cumulative feed intake, feed efficiency, cold carcass weight and cold carcass yield in quails were higher in the trial groups compared to control group (P<0.05); but organ weights were not affected (P>0.05). Levels of liver malondialdehyde (MDA), ceruloplasmin, and sialic acid were lower, but levels of superoxide dismutase (SOD) were higher in trial groups (P<0.05), and there was no effect on total antioxidant status (TAS) levels (P>0.05). Serum MDA levels were lower and SOD levels were higher in liquid colostrum supplemented groups (P<0.05), although a numerical increase was found in TAS levels, no statistically important difference was found in trial groups. In conclusion, the oxidative, transport and slaughter stresses can be attenuated by liquid colostrum supplementation at 4% of diets in quail.Öğe EFFECTS OF GENISTEIN, ESTROGEN AND PROGESTERONE THERAPIES ON BLADDER MORPHOLOGY AND M2, M3 RECEPTOR EXPRESSIONS IN OOPHORECTOMIZED RATS(Carbone Editore, 2014) Turgut, Abdulkadir; Goruk, Neval Yaman; Sak, Muhammet Erdal; Deveci, Engin; Akdemir, Fatih; Keles, Ayse Nur; Nergiz, YusufAims: Investigating the effects of estrogen, estrogen/progesterone combination and genistein therapy on the expression of M2 and M3 receptors located on bladder walls and comparing the morphological and degenerative changes exerted on bladder walls. Materials and methods: A total of 50 adult Sprague-Dawley female rats were randomly divided into five groups. Rats other than the sham group were ovariectomized. OVX group (control group) received water, OVX+G group received 10 mg/kg genistein, OVX+E group received 0.014 mg/kg 17-beta estradiol, OVX+E+P group received 0.014 mg/kg 17-beta estradiol plus 0.028 mg/kg drospirenone per day. Results: When compared with the sham group, in the OVX group higher collagen fibre (CF): smooth muscle (SM) ratio, relatively increased fibrosis, oedema, space between detrusor smooth muscle fascicles, cytoplasmic vacuoles, and total M2, and M3 expression were observed. Relative to the OVX group, decreased CF: SM ratio and fibrosis in the OVX+G, OVX+E, and OVX+E+P groups, decreased oedema, spaces between detrusor muscle fascicles and cytoplasmic vacuoles in the OVX+G group and lesser total M2, and M3 expression in the OVX+G, OVX+E and OVX+E+P groups were observed. Conclusion: Genistein therapy regresses unfavourable morphological changes effecting postmenopausal bladder and increases in M2 and M3 receptor expression more effectively than estrogen and estrogen/progesterone combination. Besides, genistein therapy almost completely regresses degenerative changes; however, estrogen and estrogen/progesterone combination therapies do not improve these degenerative changes except for fibrosis. We think that genistein will favourably contribute both to the conduction of more comprehensive studies in the future concerning its use in postmenopausal urinary incontinence where estrogen and estrogen/progesterone combination therapies do not provide any improvement and etiopathogenesis of urinary incontinence.Öğe Evaluation of the Protective Effects of CoQ10 on Ovarian I/R Injury: An Experimental Study(Karger, 2013) Ozler, Ali; Turgut, Abdulkadir; Goruk, Neval Yaman; Alabalik, Ulas; Basarali, Mustafa Kemal; Akdemir, FatihBackground: The aim of this study was to investigate the protective effects of coenzyme Q(10) (CoQ(10)) on ovarian ischemia/reperfusion injury in an experimental rat adnexal torsion model. Methods: 48 female adult Wistar albino rats, weighing 220-250 g, were randomly equally divided into six groups (n = 8): sham, torsion, detorsion, sham+CoQ(10), torsion+CoQ(10), and detorsion+CoQ(10) groups. Bilateral adnexal torsion was performed for 3 h in all groups, except the sham and sham+CoQ(10) groups. Bilateral adnexal detorsion was performed on the detorsion and detorsion+CoQ(10) groups. CoQ(10) was injected intraperitoneally 30 min before the sham operation, torsion, and detorsion. Results: The torsion and detorsion groups had significantly higher histologic evaluation scores, as well as higher MDA levels, TOS values, and oxidative stress index values than the sham group. A strong correlation between total histologic evaluation scores for ischemia/reperfusion injury and the oxidative stress index was found. The mean oxidant marker levels and histopathologic scores for the ovarian tissue significantly decreased after using CoQ(10), which is a potent antioxidant. Conclusions: Conservative surgery (detorsion) was found to provide inadequate protection to ovarian tissue. The results of this study suggest that CoQ(10) could be useful for the protection of ovarian tissue before conservative surgery. (C) 2013 S. Karger AG, BaselÖğe Impact of chromium histidinate on high fat diet induced obesity in rats(Bmc, 2011) Tuzcu, Mehmet; Sahin, Nurhan; Orhan, Cemal; Agca, Can Ali; Akdemir, Fatih; Tuzcu, Zeynep; Komorowski, JamesBackground: Chromium (Cr) is an essential trace element that has garnered interest for use as a weight loss aid, but its molecular mechanism in obesity is not clear. In this study, an attempt has been made to investigate the effects of chromium histidinate (CrHis) on glucose transporter-2 (GLUT-2), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), nuclear factor-kappa B (NF-kappa B p65) and the oxidative stress marker 4-hydroxynonenal adducts (HNE) expressions in liver of rats fed high fat diet (HFD). Methods: Male Wistar rats (n = 40, 8 wk-old) were divided into four groups. Group I was fed a standard diet (12% of calories as fat); Group II was fed a standard diet and supplemented with 110 mu g CrHis/kg BW/d; Group III was fed a HFD (40% of calories as fat); Group IV was fed HFD and supplemented with 110 mu g CrHis/kg BW/d. Results: Rats fed HFD possessed greater serum insulin (40 vs. 33 pmol/L) and glucose (158 vs. 143 mg/dL) concentration and less liver Cr (44 vs. 82 mu g/g) concentration than rats fed the control diet. However, rats supplemented with CrHis had greater liver Cr and serum insulin and lower glucose concentration in rats fed HFD (P < 0.05). The hepatic nuclear factor-kappa B (NF-kappa B p65) and HNE were increased in high fat group compared to control group, but reduced by the CrHis administration (P < 0.05). The levels of hepatic Nrf2 and HO-1 were increased by supplementation of CrHis (P < 0.05). Conclusion: These findings demonstrate that supplementation of CrHis is protective against obesity, at least in part, through Nrf2-mediated induction of HO-1 in rats fed high fat diet.Öğe A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats(Taylor & Francis Ltd, 2012) Sahin, Nurhan; Akdemir, Fatih; Orhan, Cemal; Aslan, Abdullah; Agca, Can A.; Gencoglu, Hasan; Ulas, MustafaAims: A novel nutritional supplement complex (N21 #125) composed of four well-known compounds (chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron) was designed to improve memory function and maintain brain health. The present study evaluated the complex's potential mechanism of action and its role in reducing oxidative stress in the brain of obese rats fed a high-fat diet (HFD). Methods: Male Wistar rats (n = 40, 8-week-old) were divided into four groups. Group I was fed a standard diet; Group II was fed a standard diet and supplemented with N21 #125; Group III was fed an HFD; and Group IV was fed an HFD and supplemented with N21 #125 for 12 weeks. Results: Rats fed HFD had greater serum C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-alpha) and brain malondialdehyde (MDA) concentrations than rats fed the control diet. Supplementation of N21 #125 decreased CRP, TNF-a, and MDA concentration in rats fed HFD. The levels of brain nuclear factor-E2-related factor-2 (Nrf2), heme oxygenase, extracellular signal-regulated kinases and protein kinase B were lower in rats fed the control diet than for rats fed the HFD. These parameters were increased by supplementation of N21 #125. Discussion: The data indicate that N21 #125 protected the brain from oxidative damage and inflammation induced by the HFD. This effect may be through up-regulation of the transcription factor Nrf2 expression.Öğe The protective effect of curcumin on ischemia-reperfusion injury in rat ovary(Elsevier Science Bv, 2013) Sak, Muhammet Erdal; Soydinc, Hatice Ender; Sak, Sibel; Evsen, Mehmet Siddik; Alabalik, Ulas; Akdemir, Fatih; Gul, TalipBackground: To evaluate the protective effects of curcumin in experimental ischemia and ischemia/reperfusion (I/R) injury of rat ovaries. Methods: Forty-eight female adult Wistar Albino rats were used. Rats divided into six groups and designed: Sham, Torsion, Detorsion, Sham + Curcumin, Torsion + Curcumin, and Detorsion + Curcumin. Except for the Sham and Sham + Curcumin group, all groups were performed to bilateral adnexal torsion for 3 h. Bilateral adnexal detorsion was implemented in the Detorsion and Detorsion + Curcumin groups. The injection of curcumin was intraperitoneally achieved 30 min before the sham, torsion and detorsion. Results: Total oxidant status levels (TOS), oxidative stress index (OSI) and histologic scores values of ovarian tissue were higher in the torsion and detorsion groups than the sham group (p < 0.05). There was a strong correlation between the total histologic scores of I/R injury and the OSI (r = 0.809, p < 0.001). By the use of curcumin, a significant decrease was established in the mean levels of oxidant markers and histopathologic scores of the ovarian tissues. Conclusions: Administration of curcumin is effective in reversing tissue damage induced by ischemia-reperfusion injury in ovarian torsion. (C) 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
