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Role of cited-1 and caspase-6 expression in HELLP syndrome
(Verduci Publisher, 2023) Ocal, E.; Akalin, S. Alkan; Asir, F.
OBJECTIVE: In this study, we investigated the immunohistochemical staining of cited-1 and caspase-6 expression in the placentas of pregnant women with HELLP syndrome.PATIENTS AND METHODS: Placentas of 20 normotensive patients and 20 women with HELLP syndrome were processed for routine histological tissue processing. The biochemical and clinical parameters of patients were record-ed. Placentas were stained with hematoxylin-eosin and cited-1 and caspase-6 immunostaining.RESULTS: Placentas of normotensive patients showed normal histology. Placentas of women with HELLP syndrome showed degenerated cells, hyalinization and vacuolization. Cited-1 ex-pression was negative in normotensive group; however, it was increased in HELLP group, especially in decidual cells, endothelial cells and other placental cells. Caspase-6 expression was negative in placental structures of normotensive groups. However, it was intense in decidual cells, vacuolar and hyalinized areas, inflammatory cells and connective tissue cells in HELLP group.CONCLUSIONS: Cited-1 and caspase-6 are a marker in determining the severity of HELLP syndrome.