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Öğe Evaluation of clinical and epidemiological features of children with facial viral warts(Dermatologia Pediatrica, 2014) Uçmak D.; Akkurt Z.M.; Dal T.; Acar G.; Arica M.Verrucae are viral lesions commonly encountered in the pediatric population. They occur relatively rarely on the face. The occurence of verrucae in the facial region leads to limitation in treatment modalities and increases patient discordance. The clinical and epidemiological data of 37 patients (26 females) seen at the Dicle University Faculty of Medicine Dermatology outpatient clinics from January 2012 to January 2013 were reported. The mean age of the patients was 10.43±4.51 (range 4-18). The mean duration of lesions was 16.59±14.90 months. Number of lesions ranged from 1 to 50 (mean: 15.92). The most common localization on the facial area was the cheek in 23/37. Extrafacial involvement was present in 5/37 patients. The most common type of verruca in the facial region was verruca plana (50%). Before admission to our clinic, 56.8% had not received any form of treatment. Treatment modalities included reassurance - 16% -, cryotherapy -10.8% -, topical treatment with tretinoin cream, salicylic acid + 5-FU solution - 5.4% - and cauterization -1%-. Twelve of the 21 patients who had not previously received therapy had periorbital lesions. Positive correlation was present between age and duration of lesions (p < 0.01, r = 0.42).Öğe Generalized pustular psoriasis in two children: Acitretin therapy: Case report(Turkiye Klinikleri, 2014) Uçmak D.; Akkurt Z.M.; Türkçü G.; Acar G.; Akdeniz S.; Arica M.Von Zumbusch type pustular psoriasis is rarely seen in pediatric patients. Attacks of pustular psoriasis are characterized by fever that lasts several days, followed by sudden onset of pustules. The pustules are disseminated over the trunk and extremities, including the nail beds palms, and soles. Acitretin, alone, or combined with oral corticosteroids, is the first-line treatment method. Methotrexate or cyclosporine may also be used. Acitretin is a second generation aromatic retinoid. It takes effect by regulating keratinocyte proliferation and differentiation. A two-yearold girl and a three-year-old boy, presented with widespread pustules on an erythematous background, accompanied by fever and leukocytosis. Skin and blood cultures were negative. A diagnosis of Von Zumbusch type pustular psoriasis was made. We present two pediatric cases of generalized pustular psoriasis responding to acitretin rapidly and effectively. Copyright © 2014 by Türkiye Klinikleri.Öğe Herpes simplex superinfection with hailey-hailey disease: Case report(Turkiye Klinikleri, 2013) Uçmak D.; Harman M.; Akkurt Z.M.; Türkçü G.; Acar G.Hailey-Hailey disease (familial benign pemphigus) is an autosomal dominant acant-holytic dermatosis. The disease shows painful erosions and vesicles situated on an erythematous background especially in the intertriginous area. Herpes simplex infection associated with Hai-ley-Hailey disease differs from eczema herpeticum in that it is more localized. A 55-year-old female presented with vesicular lesions on the edge of wide inguinal erosions. A Tzanck smear revealed single hypertrophic nucleated acantholytic round cells with basophilic cytoplasm and one or two marked nucleoli at the periphery of the nucleus, adjacent to the nuclear membrane. Herpes simplex superinfection of Hailey Hailey disease is very rare and may not come to mind in diagnosis. A Tzanck smear, which is faster and easier than other tests for diagnosis, should be undertaken when there is clinical suspicion of herpes infection and antiviral treatment should be administered without delay. Copyright © 2013 by Türkiye Klinikleri.Öğe The relationship between coagulation factor XI levels and cardiac syndrome X in patients with diabetes mellitus(Cardiology Academic Press, 2014) Yazicioglu M.V.; Yuksel M.; Batgerel U.; Acar G.; Avci A.; Simsek Z.; Tabakci M.M.Cardiac syndrome X (CSX) is a characterized with normal epicardial coronary arteries and exertional angina pectoris. The aim of this study was to measure the levels of coagulation factor XI (F XI) and XII (F XII) to compare the intrinsic coagulation pathway activities in DM patients with and without CSX. A total of 50 Type 2 DM patients with CSX diagnosed by non-invasive tests accompanied with coronary angiography, and control group of 51 Type 2 DM patients matching with the CSX group in terms of age and sex were included in the study. F XII levels were tended to be higher in patient group than controls [107 ± 26 vs 99 ± 21 IU/dL; p = 0.124, respectively]. Moreover F XI levels were found to be significantly higher in CSX patient group compared to the controls [130 ± 23 IU/dL vs 118 ± 17 IU/dL; p = 0.005, respectively]. This study demonstrates that intrinsic coagulation pathway of DM patients with CSX is more active than those without CSX. It is also suggested that hypercoagulability may play an important role in the pathogenesis of CSX.