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Öğe Acute pulmonary embolism(Logos Medical Publishing, 2012) Tanriverdi M.H.; Abakay A.Pulmonary embolism (PE) is a common and life-threatening emergency cardiovascular disorder. PE does not occur with a specific clinical picture, so the diagnosis can be difficult. Early diagnosis and treatment is crucial to save lives. PE an deep vein thrombosis (DVT) is associated with venous thromboembolism (VTE) and have common predisposing factors. In most cases, Cause of PE commonly is DVT. Among the factors that cause PE include age, history of VTE and such as cancer, neurological disease, acute respiratory failure or heart disease that requires long hospitalization diseases, oral contraceptive use and congenital or acquired thrombophilia. Smokers, obese people, patients with hypertension or metabolic syndrome has been reported that a high risk of PE. Increases plasma level of D-dimer that fibrin degradation product. The venous ultrasound of lower extremity is first step tests in patients with suspected PE. Because it's noninvasive, easy to apply and has a high specificity. Normal ventilation-perfusion (V/Q) scintigraphy is a highly secure PE outside. Single-detector spiral CT, is sufficient in showing the presence of segmental or proximal level clinically apparent PE. Pulmonary angiography is extremely reliable, but is an invasive test. Critical condition in which the patients with suspected PE echocardiography at the beginning of beds, especially the granting of emergency treatment is useful for decision. The aim of treatment is to ensure the re-flow from the pulmonary artery is clogged. The first-line treatment of patients with high-risk PE is thrombolytic therapy is that very few absolute contraindications.Öğe Altitude: Is determinant for tuberculosis incidence?(2006) Tanrikulu A.Ç.; Abakay A.; Abakay Ö.; Alp A.In the last year, there have been very important improvements about tuberculosis (TB) all over the world. In this study, it was researched TB control studies at two cities in Turkey between 1999 and 2003 in order to determined the factors affecting to TB prevalence. The forms using those dispensaries in two cities to informing about diagnosis and treatment of TB have been investigated retrospectively. In This period, 2387 new TB patients were determined in Diyarbakir, 1844 (77.2 %) of them were pulmonary TB and 543 (22.8 %) extrapulmonary TB. 691 (37.5 %) with pulmonary TB were smear positive. In same period, 375 new TB patients were determined in Kars, 276 (73.6 %) of them were pulmonary TB and 99 (26.4 %) extrapulmonary TB. 50 (18.1 %) patients with pulmonary TB were smear positive. The average incidence of TB was 37.55/100000 in Diyarbakir and 19.59/100000 in Kars (p<0.05). The average incidence of pulmonary TB was 29.04/100000 in Diyarbakir and 14.53/100000 in Kars (p<0.05). The altitude at Diyarbakir is 660 meters and 1768 meters in Kars. According to research from the State Planning Organization of Turkey, there has been an important difference regarding the rates of urbanization and rates of literacy between two city (p<0.05). It was thought that the significant difference regarding incidence of TB between two cities was due to the difference of altitude of those city (2.3 times). Moreover, it was thought that some socioeconomic parameters could be affective on TB prevalence. However, some extensive study should be carrying out to clearly understand the factors affecting TB prevalence.Öğe Approach of doctors about diagnosis and treatment of COPD(2005) Abakay A.; Tanrikulu A.Ç.; Kirbaş G.; Eren-Da?li C.; Aritürk Ö.; Palanci Y.It is known that primary care level doctors make mistakes and use spirometry less for the diagnosis of COPD. In this study, it was aimed to learn the approach of doctors about COPD and precautions that must be taken were discussed. A questionnaire including 13 questions were applied to 230 doctors from 1.2. and 3. care levels in Diyarbakir and Mardin in November 2003. 119 (%51.7) practitioners, 68 (% 29.6) interns and 43 (%18.7) specialists (9 chest diseases, 23 internal diseases and 11 other) were included. Of the doctors; 157 (%68.3) expressed dyspnea, 54 (%23.5) cough, 15 (% 6.5) sputum as a symptom of priority. Comparing the period of being a doctor with knowledge of symptom, the level of knowledge was found to decrease as the period increased and this difference was significantly important (p=0.007). The level of awareness that spirometry (SFT) is the definite diagnosis method decreased as the period of being a doctor increased (p=0.0001). This subject was best known by chest diseases specialists then intern doctors. Significant difference was found between branches (p=0.0001). Finding SFT necessary for diagnosis was detected as %78 in doctors having SFT in their institutions and as %56 in doctors not having PFT (p=0.0001). The doctors having SFT found spirometric investigation necessary 2.73 (1.51-4.95) fold higher than the doctors not having SFT. Statistically no significant difference was detected among the doctors about period and branch relating the risk factors of COPD, precautions that must be taken the choice of treatment and usage of antibiotics. The level of information decreases among doctors as the period of being a doctor increases and in the places not having PFT the level of knowledge of doctors is worse. Periodic education and providing PFT in the primary care level will be usefull in the struggle against this disease.Öğe Close contacts examination and chemoprophylaxis care level of Diyarbakir no 1 tuberculosis control dispensary(2006) Abakay A.; Abakay Ö.; Tanrikulu A.Ç.; Coşkunsel M.The preventive chemothreapy is important for preventing of tuberculosis in the close contacts. This regard the close contacts of tuberculosis patients are evaluated carefuly. In this study we investigated retrospectively 1986 close contacts of 360 tuberculosis patients who registered Diyarbakir No. 1 Tuberculosis Control Dispensary. In the tuberculosis patients, the mean age 31.5±16.1 years, 218 (% 60.6) cases were male and 142 (% 39.4) cases were female. Examinations reasons of tuberculosis patients were as 280 (% 77.8) and 74 (% 20.6) individual examination and close contact examination, respectively. It was found that index cases were as % 75 of pulmonary tuberculosis and % 25 extra pulmonary tuberculosis. Pulmonary tuberculosis cases were as % 63.7 of smear positive % 36.3 of smear negative. In the close contacts, the mean age 20.2±16.9 years, 948 (% 47.8) cases were male and 1038 (% 52.2) cases were female. It was found that mean 5.51±2.96 close contacts per a tuberculosis patient were recorded. It was found that examination was not made in the 596 (% 30) cases of close contacts. The number of examinated cases of close contacts was 1390. Examination results in the examinated cases were as follows respectively: preventive chemothreapy was applied in 264 (% 18.9) of the cases; active tuberculosis disease were determinated in 32 (% 2.3) of the cases; BCG was applied in 92 (% 6.7) of the cases; second control examination was suggested in 14 (% 1.1) of the cases. Preventive chemothreapy should be applied in 631 (% 45.4) of the examinated close contacts according to National Tuberculosis Guideline. However, it was found that preventive chemothreapy was not applied. It was determinated that the examinated rate was decreased because of the index cases were uneducated and unemployed and the examinated rate was not decreased because of the index cases were uninsured. Conclusion: Some defects were established in the care of tuberculosis control dispensary. It is thought the defects can be corrected by means of the application National Tuberculosis Guideline and the increasing education activities.Öğe Comparison of approaches in tuberculosis diagnosis between dispensary and chest diseases clinics and defects into practice(2006) Abakay A.; Abakay Ö.; Tanrikulu A.Ç.; Coşkunsel M.Tuberculosis (TB) is an important health problem for our country. Tuberculosis conrol dispensaries (TCD) undertake important functions in application of national TB control programme. In this study, comparison of diagnosis methods in TB is aimed between Diyarbakir No.1 TCD and chest diseases clinics. The data of 360 cases were investigated retrospectively in Diyarbakir No.1 TCD. Systematic sample method was used in the selection of this cases within registered 916 cases between January 200? and December 2004. It was found that cases were as 270 (% 75) pulmonary TB and 90 (% 25) extra pulmonary TB. Pulmonary tuberculosis cases were as 172 (% 63.7) of smear positive 98 (% 36.3) of smear negative. Bacteriological and nonbacteriological methods were used in the 117 (% 72.2) cases and 45 (% 27.8) cases of 162 cases as diagnosed at pulmonary TB chest diseases clinics, respectively. Bacteriological and nonbacteriological methods were used in the 58 (% 64.4) cases and 32 (% 35.6) cases of 90 cases as diagnosed at pulmonary TB Diyarbakir No. 1 TCD, respectively. It was found that the diagnosis of 15 (% 46.8) cases that diagnosed by nonbacteriological methods at TCD was determinated to be as false by chest diseases clinics that have different diagnosis possibility. It was determinated that the mean treatment time was 7.51 ± 2.90 month. It was found that the 56 (% 15.6) cases were made some errors according to treatmet regime or treatment time. The false rate was found to be high when used nonbacteriological methods at TCD. National TB programme is suggested that smear negative cases are sent to health centers having different diagnosis possibility. As a result of, our study is in agreement this suggestion.Öğe Comparison of tuberculosis screening results obtained at centrum and village schools(2007) Abakay A.; Abakay Ö.; Çetin Tanrikulu A.Severity forms of tuberculosis (TB) can be seen more frequent in chilhood. Therefore, preventive cases are important at children. Tuberculosis screening was made by The TB Control Eleventh Group Presidency on the primary school students at total seven schools in Diyarbakir (three school located at centrum and four schools locate at villages), at November, 2005. Total 1181 children containing 681 from centrum and 500 from villageswere taken tis study. In the centrum children. 334 (49.1 %) were female and 347 (50.9 %) children were male and the mean age 6.99±0.97 (6-13) years. In the villages children, 277 (55.4 %) were female and 223'ü (44.6 %) children were male and the mean age 7.94±1.65 (5-13) years. It was found that the numbers of children that not made Bacillus Calmette-Cuerin (BCG) vaccine were 360 (52.9 %) and 121 (24.2 %) at centrum and villages, respectively. The tuberculin skin test (TST) mean diameters were 1.35±1.8 mm, 3.5±4.15 mm and 10.33±2.96 mm at no BCG children, one BCG scar group and two BCG scar group, respectively. It was found that the TST mean diameter were 2.6±3,5 mm 2.8±3.7 mm and at children in centrum and villages, respectively. The diameter difference between centrum and villages was not found to be meaningful statistically in the no BCG group, two BCG scar group and all children (p>0.05). The diameter difference between centrum and villages was found to be meaningful statistically in the one BCG scar group (p<0.05). It was found that total 14 TST containing 12 no BCG group and 2 one BCG scar group were positive in all children. It was determinated that the vaccine rate was fairly low interestingly in the centrum. Increasingthe BCG vaccine number increased meaningfully the TST mean diameter. The vaccine rate must be increased because of it was found that increasing the BCG vaccine number increased meaningfully the TST mean diameter.Öğe Effects of treatment regimens on survival in patients with malignant pleural mesothelioma.(2013) Abakay A.; Abakay O.; Tanrikulu A.C.; Sezgi C.; Sen H.; Kaya H.; Kucukoner M.In this study, we aimed to investigate the factors affecting the survival of patients with malignant pleural mesothelioma (MPM) according to their treatment regimens, including best supportive care (BSC), chemotherapy, surgical group and multimodality (MM) therapy. A retrospective analysis was performed on clinical data and treatment outcomes of 400 patients registered in our hospital with MPM between January 1989 and April 2010. Mean age (p < 0.001), presence of asbestos exposure (p = 0.0014), presence of smoking history (p < 0.001), Karnofsky performance status (p < 0.001), histological subtype (p = 0.034) and stage (p < 0.001) variables were found to be significantly different among the four treatment regimens. Mean survival time of all patients was 12.32 months. Mean survival time 10.5 months for the BSC group, 15.7 for the surgical group, 16.02 for the chemotherapy group, and 26.55 for the MM group. There were significant differences in mean survival time among the four treatment regimens. In addition, a significant difference was found in survival time between the two chemotherapy groups (p = 0.032). Mean survival time for cisplatin + gemcitabine was found to be 14.49 months and for cisplatin + pemetrexed, 18.34 months. The MM group had better survival rates than the other groups. The new chemotherapy combination, cisplatin + pemetrexed, can be helpful in improving survival time.Öğe Environmental malignant pleural mesothelloma in Southeast Turkey(2006) Tanrikulu A.C.; Senyigit A.; Dagli C.E.; Babayigit C.; Abakay A.[No abstract available]Öğe Neurofibromatosis and pleural neurofibroma: Case report(Logos Medical Publishing, 2011) Şen H.S.; Aydin A.; Abakay A.; Şenyi?it A.There is various pulmoner attacks of neurofibromatosis. We presented a neurofibromatosis case with pleural lesion in this study. Fourty four years old male patient. There is a lot of dermal nodules in different sides of his body since childhood. Thorax and abdominal Computed Tomography (CT) has taken. There was a noduler lesion in left lung lower lobe superior segment. It was 43*22 mm size and spurred to pleura. Routine examinations, tumoral markers, fiberoptics bronchoscopy, respiratory function tests and carbon monoxide diffusion capacity test were assessed in normal limits. One biopsy material has taken from dermal lesion. Dermal biopsy result was neurofibrom. After three mounths there was not any difference in lesion at control Thorax CT. The pleural lesion considered as thoracic neurofibroma. There is different pleuropulmoner lesions in neurofibromatosis patients. When we detect pleural mass in neurofibromatosis cases, we must think neurofibrom originated from primer disease in seperator diagnose.Öğe The predictive value of CRP, CEA, IL-6, IL-8, and TNF? in the diagnosis of malignant pleural effusions(2012) Sen H.S.; Abakay O.; Dalli A.; Sezgi C.; Abakay A.; Coskunsel M.Aim: In this study, we investigated the potential utility of some simple, rapid, biochemical tests that detect the tumor markers interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor alpha (TNF?), C reactive protein (CRP), and carcinoembryonic antigen (CEA) in diagnosing malignant pleural effusions (MPEs) in exudative pleural fluids. Material and Methods: The study included 70 patients who had exudative PEs. The presence of CRP, CEA, IL-6, IL-8, and TNF? were investigated in the patients' pleural fluids. The cases were grouped into a malignant pleural effusion (PE) group (n = 27) and a benign PE group (n = 43) according to their etiological diagnosis, and the median levels of CRP, CEA, IL-6, IL-8, and TNF? in the two groups were compared. Results: The levels of pleural fluid CEA and IL-6 were significantly higher in the malignant PE group compared with the benign PE group (p <0.01 and p = 0.002, respectively). A meaningful difference was not found between the median value of the pleural fluid CRP IL-8 and TNF? levels in the two groups (p >0.05). We used Roc curve analysis to determine the sensitivity and specificity of CEA as a marker of malignant pleural effusion. When the CEA cut-off point was 1 ng/ml, the sensitivity was found to be 85%, and the specificity was found to be 51%. When the CEA cutoff point was 17 ng/ml, the sensitivity was 29%, and the specificity was 97%. Conclusion: Although the number of cases in the study is low, our findings suggested that CEA and IL-6 may be useful in distinguishing whether exudative PEs are malignant or benign.Öğe Pulmonary findings in patients with fascioliasis(Acta Medica Mediterranea, 2013) Sezgi C.; Cicek M.; Sen H.S.; Kaya H.; Taylan M.; Abakay A.; Abakay O.Aim: Fasciola hepatica (FH) is sporadically found in the humans and causes disease by involving the bile ducts. However, it is rarely localized ectopically in the lungs; typical and atypical involvement of lung have been shown. The aim of this study is to investigate pulmonary findings for clinical, radiologic and laboratory in patients with fascioliasis. Materials and methods: All patients included in this study were diagnosed with fascioliasis. Diagnosis of fascioliasis was made by IgG antibody detection with ELISA, detection of parasite eggs with stool examination, radiologic images and clinical findings and laboratory parameters. Diseases involving in the differential diagnosis of lung involvement were individually evaluated when an abnormality was detected on chest radiography. Additional biochemical and microbiologic tests were performed. Thoracic computed tomography (CT), fiberoptic bronchoscopy and thoracentesis were performed. When other diseases were eliminated, the patient was diagnosed with fascioliasis. Results: Lung involvement was detected in 3 out of 56 patients (5.35%). The most prominent symptoms were right hypochondrial pain, chest pain, cough and dyspnea. Hepatomegaly and pulmonary rales were the most common physical examination findings. On radiologic imaging of the lung, ground-glass densities were detected in one patient, infiltration in one and pleural effusion was detected in the other. Conclusion: Although Fasciola hepatica may only affect the lungs rarely, the presence of respiratory symptoms and physical examination findings in the acute period of diagnosis should suggest lung abnormality.Öğe A Rare Hydatid Cyst Involvement: Bilateral Pulmonary Artery (Case Report)(2010) Abakay A.; Gümüş H.; Tanrikulu A.C.; Atilgan Z.A.; Avci A.Hydatid cyst is a parasitic disease that may involve many organs. Hydatid cyst with pulmonary artery involvement is a very rarely encountered form. It was aimed to present a rare bilateral pulmonary artery involvement determined in a 61-year-old male case with hydatid cyst. In our case, the lesions were determined in many segments of bilateral lungs, right atrium lateral wall of the heart and in many branches of bilateral pulmonary artery. Pathological evaluation of the patient underwent surgery for the cardiac mass revealed hyda-tid cyst. The patient, who refused the proposal of surgery for the lesions in lungs and pulmonary artery, was given medical drug therapy. We think that it may be helpful to include hyda-tid cyst in prediagnosis list for the patient applied to a doctor with multiple cystic or nodular images.Öğe Rifampycine induced trombositopenia: A case report(2010) Tanrikulu A.C.; Abakay A.; Turan H.Tuberculosis (TB) is still remained serious public health problem. Anti-TB treatment is given twice weekly caused by immun thrombocytopenia. This complication is rare when the medication is given in small daily doses (10 mg/kg). 16 years old man case with anti-TB is given daily doses (10 mg/kg) but to develop this complication is reported. This patient had applied to emergency service with epistaksis and is administered symptomatic therapy. Patients who had taken anti-TB treatment this complication to retain and should be follow.Öğe Should sputum ARB evaluation done in patients with squamous cell cancer?(2006) Akyildiz L.; Abakay A.; Topçu F.; Aritürk-Abakay Ö.A seventy one year old /man patient was admitted to our hospital with cough, sputum hemoptysis and weight lose that were present for two months. Physical examination revealed bilateral rales. On his chest X-ray caviter lesion with pericavitier infiltration was seen in middle zone. Thorax CT showed the infrahiler mass including irreguler bordered, thick walled cavitier lesion. Bronchoscopic endobronchial biopsy revealed squamous cell cancer and caseifie granulomatous bronchit in the entrance of right lower lobe. Anti-Tbc chemotherapy had been started with four drugs (HREZ) because the sputum ARB results were positive. The patient died because of respiratory failure in fifteenth day of therapy. One month prior to admission of the patient to our hospital, bronchoscopic endobronchial biopsy that was done in an another center revealed squamous cell cancer and also granulomatous process but despite thus any other diagnostic evaluation (such as sputum ARB) had not been performed. We aimed to notify that sputum ARB evaluation should be done in all patients with pulmonary cavitier lesions for differential diagnosis especially in countries that tuberculous is a common infection like our country.Öğe Spinal tuberculosis: A retrospective chart review(Acta Medica Mediterranea, 2014) Sezgi C.; Taylan M.; Kaya H.; Sen H.S.; Abakay O.; Bulut M.; Abakay A.Aims: Background and objectives: This study aimed to investigate the clinical characteristics, diagnostic methods, and therapeutic outcomes in patients with spinal tuberculosis (TB) in Southeastern Turkey Methods: Patients diagnosed with spinal TB at Dicle University Hospital, Diyarbakir, Turkey, between October 2005 to December 2010 were enrolled in the study retrospectively. Patients were evaluated for the following: Clinical presentation, underlying diseases, laboratory results, imaging findings, medical therapies, and treatment outcomes Results: A total of 23 patients including 14 men and 9 women with spinal TB, also known as Pott's disease, were enrolled. The study subjects' ages ranged from 17 to 69 years with a mean age of 38.4 years. Patients most often presented with back pain (69.5%, n=16) and fever (56.5%, n=13), and the most frequent physical finding was spinal tenderness (91.3%). Only 17.4% of the patients demonstrated neurological deficits and no paraplegia was observed. The time interval between onset of symptoms and treatment initiation was 3.2 months. Of all the patients, 47.8% exhibited Pott's disease in the thoracolumbar region while 34.8% only had thoracic involvement. On average, 2.5 vertebrae were diseased in this cohort. Furthermore, 82.6% of the patients had paraspinal and psoas abscesses. All patients were treated with anti-TB therapy. However, 26.1% required additional surgery, and one patient with miliary TB died. The mean treatment course lasted for 12.3 months. Conclusions: It may be possible to refine methods of spinal TB detection and diagnosis by studying thoracolumbar pathology in young adults with Pott's disease in endemic countries such as Turkey. By studying the clinical progression of this disease, the delay between symptom onset and diagnosis may be decreased so that complications such as paraplegia and surgical interventions are avoided.