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  • Küçük Resim
    Öğe
    Investigation of placental hofbauer cells byimmunohistochemistry methods in complicated pregnancies
    (International Engineering, Science and Education Group, 2021) Nergiz, Yusuf; Nergiz, Şebnem; Aşır, Fırat; Şahin, Ayşe; Ağaçayak, Elif
    Development of the placenta without any complication is essential for normal pregnancy.The placenta is a multifunctional organ that plays a vital role in fetal development. Hofbauer cells areone of the most important groups of placental cells. These cells are placental macrophages and have arole in many placental events. The aim of this study is to investigate the placental distribution anddensity of Hofbauer cells and to contribute to the understanding of the causes and pathogenesis ofcomplicated pregnancies. In this study, 60 full-term placentas were divided into 4 equal groups: control,preeclampsia, gestational diabetes (GDM), and ( hemolysis, elevated liver enzymes, low platelet) HELLP group. The placenta was dissected and the samples were fixed 10% neutral buffered formalin.Following routine paraffin wax procedure, 5 µm sections were stained with CD68 for marking Hofbauercells. In immunohistochemical evaluation, Hofbauer cells in villous stroma showed positive CD68expression. Immunostaining Findings: CD68 showed a granular staining pattern in the cytoplasm ofHofbauer cells. The group with the highest CD68 positive cell number was HELLP group and thenumber of cells per cell (1.46 ± 0.25) was significantly different from all groups. CD68 positive cellcount in the placental villus was the highest in HELLP group and the number of Hofbauer cells pervillus was significantly different from the other groups.
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    Öğe
    Premacular hemorrhage in a pregnant woman successfully treated with argon laser
    (2012) Çaça, İhsan; Cingü, Abdullah Kürşat; Şahin, Alparslan; Arı, Şeyhmus; Şahin, Ayşe
    Bu makalede, argon lazer fotokoagulasyon ile tedavi edilen Valsalva hemorajik retinopatisi olan bir olgu sunulmuştur. Yirmiyedi yaşında hamile hasta sol gözünde 3 gün önce oluşan görme azalması şikayeti ile başvurdu. Görme azalmasından hemen önce öğürme hikayesi mevcut idi. Görme keskinliği 50 cmden parmak sayma seviyesinde idi. Fundus muayenesinde makula alt yarısını kaplayan geniş preretinal hemoraji görüldü. Sistemik ve oküler hastalık, travma hikayesi mevcut değildi. Anamnez ve fundus muayenesi ile Valsalva retinopatisi tanısı kondu. Preretinal hemorajinin alt sınırına argon lazer fotokoagulasyon uygulandı. Tedaviden 1 hafta sonra hastanın görme keskinliği 10/10 seviyesine yükseldi.