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Öğe 1829 Apendektomi Materyalinin Retrospektif Olarak Değerlendirilmesi(2015) Oğuz, Abdullah; Dursun, Fatma Şule; Alabalık, Ulaş; Büykbayram, Hüseyin; Soylu, Berat; Türkçü, Gül; İbiloğlu, İbrahimAmaç: Akut apandisit en sık acil operasyon gerektiren akut batın nedenidir. Akut apandisit nedeni ile yapılan apendektomilerde nadirde olsa tümörlere rastlanır. Bu çalışmada amacımız akut apandisit ön tanısı ile yapılan apendektomilerde saptanan patolojileri geriye dönük olarak incelemektir.Gereç-yöntem: Ocak 2008- Kasım 2014 tarihleri arasında akut apandisit ön tanısı ile ameliyat edilen ve apendektomi materyalleri incelenen 1829 olgunun patoloji raporu geriye dönük olarak incelendi. Olguların yaş, cinsiyet ve patolojik tanıları kaydedildi.Bulgular: Çalışma kapsamında değerlendirilen olguların erkek/kadın oranı 1,28 olarak saptandı. Yaş dağılımları 2 ay ile 91 yaş arasında değişmekte idi. Akut apandisitin en sık izlendiği yaş aralığı 20-29 yıl olarak bulundu.Olgular histopatolojik olarak incelendiğinde, olguların % 71,3'ü akut apandisit tanısı alırken % 1,2'i apendiks neoplazisi tanısı almıştı. Negatif tanı alan olguların sayısı 497 idi. Yetişkin olgularda bu oran %25,9 iken çocuk olgularda %30,5 olarak gözlendi. Apendektomi materyallerinin %1,6'sında insidental olarak nadir görülen patolojiler izlendi. Nadir görülen patolojiler içerisinde 22 olguda (%1,2) neoplastik lezyon saptandı. Kadın ve erkek olgular hastalıkları açısından karşılaştırıldığında apendiks neoplazisi gelişimi açısından farklılık izlenmedi (p=0,288).Sonuç: Akut apandisit ön tanısı ile apendektomi uygulanan olguların apendiks materyallerinin histopatolojik olarak incelenmesi insidental olarak benign veya malign tümörleri tespit edilebileceğinden dolayı oldukça önemlidir.Öğe Bullous pemphigoid induced by metamizole in a pediatric patient(Wolters Kluwer Medknow Publications, 2018) An, İsa; Uçmak, Derya; İbiloğlu, İbrahimBullous pemphigoid (BP) is an autoimmune bullous disease commonly seen in adult population but rarely encountered in the pediatric population. Although the exact etiology of BP remains unclear, various vaccines, infectious agents, and drug use have been blamed in the etiology of BP. Here, we present a 14-year-old patient who developed BP after using metamizole and whose diagnosis was clinically and histopathologically confirmed.Öğe Comparison of ependymomas and medulloblastomas located in the posterior cranial fossa: An anatomical and histopathological study(Pisa University Press, 2020) Yılmaz, Tevfik; Öztürk, Pınar Aydın; Başar, İbrahim; Turan, Yahya; Aslanoğlu, Barış; Aydın, Kamuran; İbiloğlu, İbrahim; Tuncer, Mehmet CudiPURPOSE: Posterior fossa tumors (PFTs) include medulloblastomas, atypical teratoid/rhabdoid tumors, pilocytic astrocytomas, ependymomas, and brainstem gliomas. We evaluated patients with surgery at our clinic, comparing epidemiological, clinical, radiological, and pathological characteristics of medulloblastoma and ependymoma to identify factors that might assist preoperative diagnosis, help to develop treatment algorithms, and have prognostic value after surgery. METHODS: Pediatric patients from 0 to 16 and young adults from 16 to 29 years of age with surgery for pathologically confirmed ependymomas or medulloblastomas between January 2014 and January 2020 were eligible. The study included 19 patients, seven with ependymoma (37%) and 12 with medulloblastoma (63.2%). The ependymoma patients were 5.29 +/- 5.85 years of age, the medulloblastoma patients were 11.58 +/- 8.17 years of age, and 16 patients (84%) were children. RESULTS: Fifteen patients (79%) presented with signs of increased intracranial pressure and four (21%) presented with cerebellar findings. MRI found that 74% (14) of the PSTs were located in the midline, including six of the seven ependymomas (86%) and eight of the 12 medulloblastomas (67%). Enhancement was significantly greater in medulloblastomas compared with ependymomas (p = 0.022). In according to pathology results; synaptophysin, NSE, chromogranin and 50% GFAP positivity were observed in medulloblastoma. Ependymomas were S100 (43%) and vimentin (29%) positive. Ependymoma patients were younger than medulloblastoma patients and more were female. Conclusions: There were no significant differences in the clinical findings, but ependymomas were larger and had greater rates of enhancement and spinal metastasis compared with medulloblastomas.Öğe Dermatofibrosarkom protuberans(Türkiye Klinikleri Yayınevi, 2019) An, İsa; İbiloğlu, İbrahimElli yaşındaki kadın olgu, sol pektoral bölgede 20 yıldır var olan ve giderek büyüyen asemptomatik kitle yakınması ile başvurdu. Yapılan muayenesinde; sol pektoral bölgede yaklaşık 6x5x6 cm boyutlarında multinodüler, ekzofitik, kırmızı-mor renkli, sert ve fikse tümöral lezyon görüldü (Resim 1). Olgunun eşlik eden sistemik ve dermatolojik bir hastalığı bulunmamakta idi. Lezyonun histopatolojik incelenmesinde, dermis yerleşimli subkütan yağ dokusu infiltrasyonu görülen tümöral doku saptandı (Resim 2). İmmünohistokimyasal incelemede, tümör hücrelerinde CD34 ile pozitif boyanma görüldü. Mevcut histopatolojik ve immünohistokimyasal bulgularla dermatofibrosarkom protuberans (DFSP) tanısı konuldu. Tam kan sayımı ve karaciğer fonksiyon testlerini de içeren rutin laboratuvar testleri normal idi. Yapılan akciğer grafisi, tüm vücut kemik sintigrafisi, baş ve akciğer tomografisinde metastazik bulguya rastlanmadı. Tümöral lezyon plastik cerrahi bölümü tarafından total olarak eksize edildi. Hastadan bilgilendirilmiş onam ve fotoğraflarının yayınlanması için izin alınmıştır.Öğe Ecballium elaterium extract reduces fibrosis during wound healing in rats(Taylor & Francis, 2021) İbiloğlu, İbrahim; Alabalık, Ulaş; Keleş, Ayse Nur; Aydoğdu, Gülay; Başuguy, Erol; Büyükbayram, HüseyinWe explored the effects of subcutaneously injected Ecballium elaterium (L) A. Rich. (EE) extract on skin wound-healing in rats, as well as the effects on the liver and pancreas. Twenty-eight rats were divided into two groups of 14 each: a saline control group (S) and an EE group. Both groups were divided into two subgroups according to the day of sacrifice (S-7 and S-14, and EE-7 and EE-14). All animals received 2.5 cm skin incisions followed by subcutaneous injections of either saline or 2.5 mg/kg EE per margin (5 mg/kg in total). The S and EE groups were compared in terms of the severity and type of local and neighbouring inflammation, vascularization, fibrosis and effects on the liver and pancreas. In addition, apoptosis and vascularity between S and EE groups were compared immunohistochemically with caspase-3 and cd-34 antibodies. There was no significant difference between the staining rates of caspase-3 and cd-34 in the immunohistochemical assay between the S and E groups. Subcutaneous EE was not toxic to the pancreas or liver; the EE-14 group exhibited less fibrosis than the S-14 group. Therefore, it can contribute to the proper closure of the lesion by reducing fibrosis during wound healing.Öğe Effect of intraperitoneal thymoquinone on postoperative peritoneal adhesions(ARSMB-KVBMG, 2015) Bozdaǧ, Zübeyir; Gümüş, Metehan; Arıkanoğlu, Zülfü; İbiloğlu, İbrahim; Kaya, Savaș; Evliyaoǧlu, Osman; 0000-0001-9568-5767; 0000-0002-5780-9068Background: To determine the effect of thymoquinone on adhesion formation in a rat caecotomy/suture model. Materials and Methods: Thirty wistar rats were randomized into three groups: The control group received saline and the thymoquinone group received 10 mg/kg thymoquinone after cecal caecotomy/suture model. In the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were classified, and histopathological samples were taken. Results: There were no incisional hernias or wound dehiscences. In comparing adhesion scores, a significant difference was found between the thymoquinone and the control groups (p < 0.05). The grade of inflammation for the thymoquinone and the sham groups were significantly lower than that of the control group (p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham and thymoquinone groups compared to the control group (p < 0.05). Conclusions: Based on the results of this study in a rat peritoneal adhesion model, intraperitoneal administered thymoquinone has a strong anti-adhesive effect.Öğe Glutamine provides effective protection against deltamethrin-induced acute hepatotoxicity in rats but not against nephrotoxicity(International Scientific Literature Inc., 2015) Gündüz, Ercan; Ülger, Burak Veli; İbiloğlu, İbrahim; Ekinci, Aysun; Dursun, Recep; Zengin, Yılmaz; İçer, Mustafa; Uslukaya, Ömer; Ekinci, Cenap; Güloğlu, CahferBackground: The aim of this study was to investigate the protective effects of L-glutamine (GLN) against liver and kidney injury caused by acute toxicity of deltamethrin (DLM). Material/Methods: Thirty-two rats were indiscriminately separated into 4 groups with 8 rats each: control group (distilled water; 10 ml/kg, perorally[p.o.]), DLM group (35 mg/kg p.o. one dose.), GLN group (1.5 gr/kg, p.o. single dose.) and DLM (35 mg/kg p.o. one dose.) + GLN group (1.5 gr/kg, p.o. one dose after 4 hours.). Testing for total antioxidant status (TAS), total oxidant status (TOS), interleukin-1 beta (IL-1?), tumor necrosis factor-alpha (TNF-?), and interleukin-6 (IL-6) analyses were performed on tissue samples, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), urea, and creatinine were analyzed on serum samples. Liver and kidney samples were histopathologically analyzed. Results: The TOS level in liver was significantly higher in the DLM group than in the control group, and the level in DLM+GLN group was considerably lower than in the DLM group. The TAS level in the DLM+GLN group was considerably higher than in the control and DLM groups. The TAS level in kidney tissues was considerably lower in the DLM group than in controls, but was similar to other groups. Histopathological analyses of liver tissues established a significant difference between DLM and DLM+GLN groups in terms of grade 2 hepatic injury. However, no significant difference was found between DLM and DLM+GLN groups in terms of kidney injury. Conclusions: Glutamine leads to significant improvement in deltamethrin-induced acute hepatotoxicity in terms of histopathologic results, tissue oxidative stress parameters, and serum liver function marker enzymes.Öğe Investigation of PLGF, sFlt-1 Expression in Placenta Previa, Placenta Accreta and Normotensive Placentas in the 3rd Trimester of Pregnancy(2024) Erdoğan, Gamze; Kaya, Seval; Peker, Nurullah; İbiloğlu, İbrahim; Deveci, EnginBackground: We aimed to immunohistochemically examine the expression level of Placental growth factor (PLGF) and Soluble FMS-like tyrosine kinase-1 (sFlt-1) proteins in normotensive, Placenta accreta (PA) and Placenta previa (PP). Materials and Methods: Three groups were created for the study: 20 Nomotensive placentas, 20 PP and 20 PA from women diagnosed with placenta samples. 4-6 μm thick sections were taken from the placentas, PLGF and sFlt-1 immunostaining were applied to the obtained sections, and their expression intensities and localizations in the tissues were determined. Results: As a result of our observations, normotensive placenta group; sFlt-1 expression was observed in hofbauer cells and syncytial nodes and PLGF positive expression was observed in nuclei of muscle cells in some tunica media region. PP and PA group; sFlt-1 expression was positive in decidua cells, hofbauer cells and dilated vascular endothelium. PP and PA group; negative PLGF expression was observed in syncytial nodes and positive PLGF expression was observed in hofbauer cells and endothelial cells. There was a significant difference between normotensive, PP and PA groups (p<0.05). Conclusions: It can be thought that sFlt-1 and PLGF may be important signal stimulators and markers in the trophoblastic degeneration, apoptotic cells, increase in angiogenesis and imbalance in implanta-tion seen in cases of PP and PA.Öğe Investigation of PLGF, sFlt-1 Expression in Placenta Previa, Placenta Accreta and Normotensive Placentas in the 3rd Trimester of Pregnancy(Harran Üniversitesi, 2024) Erdoğan, Gamze; Kaya, Seval; Peker, Nurullah; İbiloğlu, İbrahim; Deveci, EnginBackground: We aimed to immunohistochemically examine the expression level of Placental growth factor (PLGF) and Soluble FMS-like tyrosine kinase-1 (sFlt-1) proteins in normotensive, Placenta accreta (PA) and Placenta previa (PP). Materials and Methods: Three groups were created for the study: 20 Nomotensive placentas, 20 PP and 20 PA from women diagnosed with placenta samples. 4-6 µm thick sections were taken from the placentas, PLGF and sFlt-1 immunostaining were applied to the obtained sections, and their expression intensities and localizations in the tissues were determined. Results: As a result of our observations, normotensive placenta group; sFlt-1 expression was observed in hofbauer cells and syncytial nodes and PLGF positive expression was observed in nuclei of muscle cells in some tunica media region. PP and PA group; sFlt-1 expression was positive in decidua cells, hofbauer cells and dilated vascular endothelium. PP and PA group; negative PLGF expression was observed in syncytial nodes and positive PLGF expression was observed in hofbauer cells and endothelial cells. There was a significant difference between normotensive, PP and PA groups (p<0.05). Conclusions: It can be thought that sFlt-1 and PLGF may be important signal stimulators and markers in the trophoblastic degeneration, apoptotic cells, increase in angiogenesis and imbalance in implanta-tion seen in cases of PP and PA.Öğe Investigation of ZIP4, ZO-1, and CLAUDIN-1 expression in thyroid tumours by immunohistochemistry and real-time polymerase chain reaction methods(Termedia Publishing House Ltd., 2023) Nacir, Mustafa; İbiloğlu, İbrahim; Alabalık, UlaşThyroid neoplasms are the most common endocrine malignancies. ZIP4 is an intramembranous zinc trans membrane protein. Zinc plays a central role in the activation of transcription factors, and zinc transporters. This affects tumour migration, invasion, and cell proliferation. ZO-1 and Claudin-1 are important tight junction proteins whose amounts increase and decrease in various cancers. In this study, we aimed to investigate the expression of ZIP4, ZO-1, and Claudin-1 in thyroid tumours and the relationship of this expression with tumour types and prognostic parameters. ZIP4, ZO-1, and Claudin-1 were studied in all cases by immunohistochemical and Real-Time PCR methods. ZIP4 and Claudin-1 tended to be expressed more in cases with tumours, while ZO-1 in cases with and without tumours. Expression of ZIP4 and Claudin-1 by real-time polymerase chain reaction showed a significant difference between histological subtypes, and this difference was not observed with ZO-1. It was observed that the presence of metastasis increased with the expression of ZIP4 and Claudin-1, and there was no significant change with ZO-1. We think that Claudin-1 and ZIP4 expression can be used as an important marker in terms of showing poor prognosis and susceptibility to metastasis in thyroid tumours, and in developing targeted therapy.Öğe Is there a difference between the direct immunofluorescence slides stored at room temperature in bright versus dark conditions?(Sci Printers & Publ INC, 2021) İbiloğlu, İbrahimOBJECTIVE: Direct immunofluorescence (DIF)-stained slides are archived in the dark to prevent fading. Reevaluation of slides for clinical evaluation and training may be needed. In this study we aimed to determine the duration of archiving in dark environment (DE) versus bright environment (BE) in order to evaluate DIF positive stained slides. STUDY DESIGN: A total of 56 immunofluorescence slides consisting of 35 kidney and 21 skin biopsies were included in the study. RESULTS: The mean wilting time of the slides was 7.5 weeks for those left in the BE and 7.1 weeks for those in the DE. The mean wilting times of the kidney slides left in BE and DE were 6.8 and 7.2 weeks, respectively. The mean wilting times of the skin slides left in a BE and DE were 8.2 and 7 weeks, respectively. CONCLUSION: We did not observe a significant difference between immunofluorescence (IF) slides archived in light versus dark media. The fact that there was no difference between the fading times between immunofluorescence slides stored in BE and DE showed that the duration of exposure to immunofluorescence microscopy light was more important than the environments where they were kept from fading on slides.Öğe Is there a difference between the direct immunofluorescence slides stored at room temperature in bright versus dark conditions?(SCI Printers & Publication INC, 2021) İbiloğlu, İbrahimOBJECTIVE: Direct immunofluorescence (DIF)-stained slides are archived in the dark to prevent fading. Reevaluation of slides for clinical evaluation and training may be needed. In this study we aimed to determine the duration of archiving in dark environment (DE) versus bright environment (BE) in order to evaluate DIF positive stained slides. STUDY DESIGN: A total of 56 immunofluorescence slides consisting of 35 kidney and 21 skin biopsies were included in the study. RESULTS: The mean wilting time of the slides was 7.5 weeks for those left in the BE and 7.1 weeks for those in the DE. The mean wilting times of the kidney slides left in BE and DE were 6.8 and 7.2 weeks, respectively. The mean wilting times of the skin slides left in a BE and DE were 8.2 and 7 weeks, respectively. CONCLUSION: We did not observe a significant difference between immunofluorescence (IF) slides archived in light versus dark media. The fact that there was no difference between the fading times between immunofluorescence slides stored in BE and DE showed that the duration of exposure to immunofluorescence microscopy light was more important than the environments where they were kept from fading on slides.Öğe Paratiroid adenomu ve hiperplazisinin histopatolojik ayrımı(Kırıkkale Üniversitesi, 2019) İbiloğlu, İbrahim; Kösem, Mustafa; Yıldız, İsmailAmaç: Paratiroid adenomu ve paratiroid hiperplazisininayrımında kullanılan histopatolojik bulgular, bu iki patolojiyiayırmada her zaman yeterli olamamaktadır. Paratiroid adenomuve paratiroid hiperplazilerinin birbirinden ayrımı tedavifarklılıkları nedeni ile önemlidir. Bu çalışmada, paratiroidadenomu ve paratiroid hiperplazisinin histopatolojik ayrımıaraştırıldı.Gereç ve Yöntemler: Çalışma grubu, 60 paratiroid adenomu, 35paratiroid hiperplazisi ve 20 normal paratiroid bezi olgusundanmeydana gelmekte olup bu gruplar arasında 18 ana histolojikparametre ile 27 alt histolojik parametre araştırıldı.Bulgular: Histopatolojik incelemede, kenarda normal paratiroidbezi varlığı, paratiroid adenomlarının %71.6’sında görülürken,paratiroid hiperplazilerinin hiçbirinde gözlenmedi. Belirgin(+++) kapsül kalınlığı, paratiroid adenomlarının %28.3’ündeizlenirken, paratiroid hiperplazilerinin hiçbirinde yoktu.Paratiroid hiperplazilerinin %48.6’sında ve paratiroidadenomlarının %10’unda (+) kapsül kalınlığı izlendi. Ortaderece ve belirgin yağ hücresi varlığı (++ ve +++) paratiroidadenomu vakalarının toplam %6.6’sında, paratiroid hiperplazisivakalarının %48.6’sında görüldü. Paratiroid adenomlarında (+)yağ hücresi varlığı %93.3 iken, paratiroid hiperplazilerinde%51.4 oranında, (++) yağ hücresi varlığı paratiroidadenomlarında %6.7, paratiroid hiperplazilerinde %42.8oranında, (+++) yağ hücresi varlığı paratiroid adenomlarındaizlenmez iken paratiroid hiperplazilerinde %8.6 olgudaizlenmiştir. Dizilim paternlerinden nest formasyonu paratiroidadenomlarının %8.3’ünde, paratiroid hiperplazilerinin%22.8’inde mevcuttu. Lenfosit infiltrasyonu paratiroidadenomlarının %26.7’sinde mevcut iken paratiroidhiperplazilerinin %8.6’sında izlendi. Fibröz bant varlığı, kistformasyonu, nest formasyonu hariç dizilim paternleri, nekroz,dejenerasyon, kanama, kolloid benzeri materyal, hücre tipi,lenfosit infiltrasyonu hariç inflamasyon, nükleer pleomorfizm,nükleer şekil, nükleer kromatin, intranükleer inklüzyon, ve mitozbakımından paratiroid adenomu ve paratiroid hiperplazisiarasında anlamlı farklılık gözlenmedi.Sonuç: Paratiroid adenomu ile paratiroid hiperplazisininayrımında kenarda normal paratiroid bezi varlığı, belirgin kapsülkalınlığı (+++), az miktarda yağ hücresi oranı (+) ve lenfositinfiltrasyonu paratiroid adenomu lehine anlamlı bulundu. Nestformasyonu, paratiroid hiperplazilerinde paratiroid adenomlarınagöre anlamlı olarak daha yüksek izlendi.Öğe Plaque with Asymptomatic Verrucous Surface on the Right Leg: Dermatofibroma(2018) An, İsa; Öztürk, Murat; Uçmak, Derya; İbiloğlu, İbrahimDermatofibroma is a benign fibrohistiocytic neoplasia. The etiology of dermatofibromaremains uncertain but it is considered to have a traumatic origin such as an insect bite orfollicular rupture. Dermatofibroma clinically presents as smooth-surface nodular lesions.We report a patient with a plaque with asymptomatic verrucous surface on the right leg.Öğe Prophylactic administration of silybin ameliorates L-arginine-induced acute pancreatitis(International Scientific Literature Inc., 2016) Uçmak, Feyzullah; Ekin, Nazım; İbiloğlu, İbrahim; Arslan, Serkan; Kaplan, İbrahim; Şenateş, EbubekirBackground: Oxidative stress have been shown to play a role in the pathogenesis of acute pancreatitis. The aim of this study was to investigate the potential effect of silybin, a potent antioxidant, on L-arginine-induced acute pancreatitis in an experimental rat model. Material/Methods: Forty female Wistar Albino rats were divided into 5 groups as follows: Group 1 (C): control group (n=8), Group 2 (SL): silybin group (n=8), Group 3 (LA): acute pancreatitis group (n=8), Group 4 (SLLA): prophylaxis group (n=8), and Group 5 (LASL): treatment group (n=8). Group C (control) received 2 intraperitoneal (i.p.) injections of physiological saline at an interval of 1 h. Group SL received only a single i.p. injection of silybin. The SLLA group received a single i.p. injection of silybin before the induction of acute pancreatitis with L-arginine, whereas the LASL group received the same injection after the induction of acute pancreatitis with L-arginine. Pancreatic tissues were histopathologically examined. Levels of amylase and oxidative stress markers (total oxidant status and total anti-oxidant status) were determined in the blood samples. Oxidative stress index was calculated. Results: In comparison to the LA, the prophylaxis and treatment groups showed significant improvements in serum oxidative stress parameters (p=0.001 and p=0.005, respectively). Histopathological analysis showed that the treatment group had significant improvements in edema scores only (p=0.006), whereas the prophylaxis group had the same improvements in inflammation and necrosis scores as well as in total scores (p=0.004, 0.006, and 0.004, respectively). Conclusions: When used for prophylactic rather than therapeutic purposes, silybin ameliorates serum oxidative stress parameters and improves histopathological results via its antioxidant and anti-inflammatory properties.Öğe Psödoksantoma elastikum: Üç kardeşten oluşan bir olgu serisi(2018) Esen, Mustafa; An, İsa; İbiloğlu, İbrahim; Aslan, Adar; Erten, RemziPseudoxanthoma elasticum (PXE) is a rare multisystemic genetic disease with dermatologic, cardiovascular and ocular involvement. PXE primarily affects the skin, and the ocular involvement is noted in almost 85% of patients. Cardiovascular complications caused by PXE often develop in adults. Since the prognosis of PXE is primarily dependent on extracutaneous organ involvement, early diagnosis of PXE is of prime importance for taking preventive measures. In this report, we present three siblings diagnosed with PXE.Öğe RADYOLOJİK VE PATOLOJİK TANISI KONAN SAFRA KESESİ FİBROMU: OLGU SUNUMU VE LİTERATÜR TARAMASI(2019) Keleş, Ayşe Nur; Türkçü, Gül; İbiloğlu, İbrahim; Alabalık, Ulaş; Çetin, AlpayFibromlar, vücudun herhangi bir yerinde özelliklede diz ve parmaklarda görülen, yavaş büyüyen, ağrısız ve sertkitlelerdir. Safra kesesi fibromusı nadir bir tümördür ve literatürde sadece birkaç adet olgu sunumu olarak yeralmaktadır. Biz burada ultrasonografi ve manyetik rezonans kolanjiyografide preoperatif olarak safra kesesipolibi tanısı konan 49 yaşında bir kadın hastayı sunmayı amaçladık. Kolesistektomi spesmeninin makroskopikincelemesinde kese hidropik görünümde olup kesitlerinde boyun kısmında polipoid bir kitle izlendi. Makrosko-bik olarak nodül, kollajenöz stromada oval yuvarlak şekilli hücrelerden oluşuyordu. Stromal hücreler Vimentinile pozitif immünreaktivite gösterdi; Desmin, S-100, SMA ve CD34 negatifti. Lezyonu safra kesesi fibromusıolarak teşhis ettik.Öğe Tonsil lezyonlarına retrospektif bakış ve malign lezyonların dağılımdaki yeri(2014) Akdağ, Mehmet; Türkçü, Gül; Fırat, Uğur; İbiloğlu, İbrahim; Avcı, Yahya; Alabalık, Ulaş; Keleş, Ayşe NurAmaç: Bu çalışmamızda tüm tonsil lezyonları içinde malign lezyonların dağılımını ve bunun literatür ile uyumluluğunu araştırdık.Yöntemler: Dicle Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalında Ocak 2006-Eylül 2013 tarihleri arasında tonsillektomi ve tonsil biyopsi materyali değerlendirilen 1118 hastaya ait patoloji raporları ve preparatları geriye dönük olarak incelenmiş ve çalışmaya alınmıştır.Bulgular: 1118 hastanın 452'sinde (%40,43) kronik iltihap, 226'sında (%20,21) lenfoid hiperplazi, 411'inde (%36,76) kronik iltihap + lenfoid hiperplazi, 2'şer (%0,18) tanesinde kist ve skuamöz papilloma ve 25'inde (%2,24) malignite izlendi. Malignite görülen 25 vakanın 19'u (%76) B hücreli non-Hodgkin lenfoma, 4'ü (%16) yassı hücreli karsinoma, 1'er (%4) tanesi de plazmasitoma ve malign melanoma'ydı.Sonuç: Primer tonsil maligniteleri tüm insan malignitelerinin %2'sini oluşturur. İlk sırada yassı hücreli karsinomlar (%75), ikinci sırada lenfomalar yer alır. Çalışmamızda bunun aksine lenfomalar malignitelerin %76 gibi önemli bir kısmını oluştururken yassı hücreli karsinomlar tüm tonsil malignitelerinin ancak %16'lık kısmını meydana getirmiştir. Tonsiller tutulum gösteren lenfomaların büyük çoğunluğunu B hücreli non-Hodgkin lenfomalar, oluşturmaktadır. Tonsil lojunda en sık görülen lenfoma tipinin diffüz büyük B hücreli lenfomalar olduğu bildirilmektedir. Bizim çalışmamızda da buna uyumlu olarak, toplam 19 lenfoma vakamızdan 15'inin diffüz büyük B hücreli lenfoma olduğunu görülmektedir.
