Yazar "Ülgen M.S." seçeneğine göre listele

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    The investigation of the relationship among xanthine oxidase, interleukin-6 and body mass index in patients with an ischemic period of acute myocardial infarction: A novel correlation
    (2011) Mustafa B.K.; Yazar H.; Büyükbas S.; Kilinc C.; Sayin K.; Ülgen M.S.
    Some cardiovascular risk factors stimulate the entrance of inflammatory cells into the arterial wall; these cells are important sources for cytokines, including interleukine-6 (IL-6). For myocardial ischemia, a superoxide radical scavenger mechanism is conducted via xanthine oxidase (XO). In this study, the relationship among IL-6, XO, and body mass index (BMI) were studied in 45 patients with acute myocardial infarction (AMI) and 30 patients in a control group. Plasma IL-6 was measured using a sandwich enzyme-linked immunoabsorbent assay (ELISA) test; XO activity was measured using Prajda's method. The mean XO levels in the patient and control groups were 0.25 ± 0.15 and 0.14 ± 0.06 U/mL, respectively. The mean IL-6 in the patient and control groups was 24.13 ± 14.8 and 14.98 ± 8.34 pg/mL, respectively. In comparison with the control group, both XO and IL-6 were significantly higher (p<0.005). In correlation analysis for the patient group, a significant correlation was found between XO and BMI (r:0.3, p<0.05). However, no correlation existed among IL-6, XO, and BMI in either the patients with AMI, or the control group. IL-6 and XO increased in patients with AMI, but no correlation existed between them, indicating that IL-6 and XO are independent markers for insufficient endothelial function in ischemic myocardium. The correlation between XO and BMI in patients with AMI is a new finding requiring further investigation.
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    Isolated mitral valve prolapsus does not affect left ventricular function
    (2011) Demir K.; Koc F.; Can I.; Vatankulu M.A.; Yazici M.; Ülgen M.S.
    Aim: Idiopathic mitral valve prolapsus (MVP) is characterized by myxomatous degeneration of mitral valve. The most common determinant of cardiovascular mortality in patients with MVP is left ventricular (LV) dysfunction. Therefore we aimed to evaluate LV functions of cases with isolated MVP by tissue Doppler echocardiography (TDE). Method: Twenty five patients with MVP (mean age, 31±12 years) were enrolled the study as MVP group. Control group was consisted 20 age and sex matched patients (mean age, 34±9 years) were enrolled to this study. LV functions were detected by using conventional echocardiography and TDE. Myocardial peak systolic (Sm), early (Em) and late (Am) diastolic filling velocities, Em/Am, isovolumetric contraction time (ICT), isovolumetric relaxation time (IRT) and ejection time (ET) were obtained in the basal segments of the inferior-septal and lateral wall. Myocardial performance index (MPI) was calculated. Result: Mild degree mitral regurgitation was present in 10 (40%) of patients with MVP, and moderate degree mitral regurgitation was present in 2 (8%) of patients. No difference was found between the two groups with regard to diastolic parameters. TDE-derivated MPI values were similar in all segments in two groups. There was significant difference between the two groups with regard to LV mean Sm and lateral wall Sm (11.6±2.8 vs. 9.4±1.0, p=0.001; 13.0±3.9 vs. 9.2±2.3, p=0.001 respectively). Conclusion: Isolated MVP without significant mitral regurgitation does not affect LV diastolic functions and MPI. However, Sm of late ral wall and LV mean was higher in patients with MVP than patients without MVP.
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    The relation between ST segment elevation shape and low dose dobutamine stress echocardiography and clinical course in early period of anterior myocardial infarction
    (2001) Karadede A.A.; Temamo?ullari A.V.; Aydinalp Ö.; Ülgen M.S.; Alan S.; Iltümür K.; Toprak N.
    Although a relation between magnitude of ST segment elevation and myocardial damage was shown in early period of acute myocardial infarction, such a relation among shape of the ST segment elevation, myocardial damage and clinical course remains obscure. Sixty-two patients with acute anterior MI, in the first six hours of their first heart attack were enrolled for the study. Based on the precordial V3 derivation prior to thrombolytic treatment, the shape of the ST elevation was separated into three groups as concave (n=26), straight (n=24) or convex types (n= 12). The relation between the shape of the elevation recorded on admission and both results of low dose (5 and 10 ?g/kg/min) dobutamine stress echocardiography (LDSE) performed (n=53) in early period (the sixth day) of infarction and clinical course were investigated. Wall Motion Score Index (WMSI) was evaluated based on a 16-segmented scoring system of which nine segments were supplied by left anterior descending artery (LAD) and points were given for each segment from one (normal) to four (dyskinetic). Basal WMSI and response to LDSE were better in LAD region. Additionally both average akinetic segment number in infarct zone was higher and improvement in these segments were less in convex and straight groups (Concave 3,78±2 vs. 2,17±2.1 p<0.01; straight 5,15±2.7vs. 4,45±2,8, NS; convex 5,4±2,3 vs. 4,8±2,1 NS; basal vs. LDSE). Although only 13% (3/23) of the patients had no improvement in LDSE in Group A (p<0.05 v.s. group B and p<0.01 v.s. group C), 35% (7/20) of group B and 60% (6/10) of Group C patients were without improvement in LDSE. Although no relation was found between better left ventricular function (WMSI <2) and shape of the ST elevation in basal evaluation in multiple logistic regression analysis (p=0.06), an independent relation was found following LDSE (p=0.01, OR 4.5, %95CI 1.3-14.7). There was no in-hospital death in concave group whereas five patients died in either straight or convex group. Arrhythmia occurrence was lower in concave group during this period (p<0.05), and exercise capacities were lower. Conclusively, we suggested that there was an increased viability in infarct zone and decreased in-hospital mortality in patients with concave ST elevation on admission. This simple classification would be beneficial to estimate left ventricular functions at discharge.
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    The value of late potential anaysis as a reperfusion criterion in acute myocardial infarction
    (2000) Iltümür K.; Kaymak H.; Ülgen M.S.; Temamoğullari A.V.; Karabulut A.; Karadede A.; Alan S.
    Various methods are available to evaluate reperfusion following thrombolytic treatment (TT) in Acute Myocardial Infarction (AMI). A few authors reported an inverse correlation between late potential (LP) positiveness and reperfusion in signal averaged ECG studies. Current prospective study was planned to investigate the value of LP analysis as a criterion of reperfusion following TT in AMI. METHODS:Ninety-two AMI patients (76 males and 16 females, with an average age of ± years) who were admitted to our clinics in the first twelve hours of pain initiation and were exposed AMI first time were enrolled. All patients had TT (TPA, n=31 or Streptokinase, n=61). Their clinical and labaratory parameters were recorded. RESULTS:Infarct related vessel was demonstrated angiographically in 69 patients (75%). Twenty-three (25%) had an occluded infarct related vessel. The LP incidence was quite low in cases with a patent infarct related vessel (7%) whereas it was higher in those with an occluded vessel (80%)(p<0.0001).Sensivity, specificity, positive and negative predictive values of LP analysis to put forward infarct related vessel patency were 95%, 80%, 92% and 87%, respectively. CONCLUSION: LP analysis with signal-averaged ECG might be used as a reperfusion criterion in AMI cases following TT.