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Öğe A case with lipoid proteinosis intersected with diabetes mellitus(Turkiye Klinikleri, 2009) Gökalp D.; Tuzcu A.; Bahçeci M.; Yildirim M.; Akdeniz S.; Özekinci S.; Urakçi Z.Lipoid proteinosis (LP) is a rare disorder inherited as an autosomal recessive trait. LP is characterized by deposition of hyaline-like material in the skin, mucous membranes, and other tissues. LP has been mapped to chromosome 1q21, the locus for the extracellular matrix protein 1 (ECM1) gene. In this case report, we aimed to present a case with LP accompanied by diabetes mellitus, and to discuss the possible mechanisms of diabetes in LP. A 16-year-old girl presented to the endocrinology department with hyperglycemia. She reported a history of progressive hoarseness of her voice since she was two years old. Our patient meets the clinical and histopathological criteria for the diagnosis of LP. Her fasting glucose was 310 mg/dl. Plasma insulin and C-peptide levels were 5.1 uU/ml and 1.57 ng/ml,respectively. Hemoglobin A1c was 12.3%. HOMA-IR (Homeostasis Model Assessment-Insulin Resistance) ratio was 3.1 (normal range <3.7). Serum islet cell antibodies, anti-GAD antibodies and anti-insulin antibodies were negative. Diabetes mellitus was diagnosed and insulin treatment was initiated. In conclusion, possible mechanism of diabetes mellitus may be result of the diffuse deposition of amorphous material into the capillary vessels or in pancreas. The other possible mechanism responsible for the association of diabetes mellitus and insulin resistance in LP patients may be sharing a mutation at 1q21 locus. Future studies which aimed screening of insulin resistance and diabetes mellitus in LP patients may be helpful to explain this association.Öğe Expression of beta human chorionic gonadotropin in the placenta of gestational diabetic mothers: An immunohistochemistry and ultrastructural study(2013) Sak M.E.; Deveci E.; Evsen M.S.; Kalkanli S.; Baran O.; Özekinci S.; Şeker U.Objective: To investigate morphologic differences of the placenta in pregnancies complicated by gestational diabetes compared to nondiabetic pregnancies. Study Design: This was a comparative morphological study of the placentas from 20 women with gestational diabetes and 20 healthy pregnancies at 28-35 weeks of gestation. Results: The presence of lesions such as fibrinoid necrosis, villous edema, syncytial knot and vascular lesions like chorangiosis was apparent, mainly in the diabetes group. There was an apparent decrease in the intensity of the human chorionic gonadotropin (hCG) immunostaining in the syncytiotrophoblast from the 28th to 35th weeks of gestation in the placentas of the healthy control group. No hCG immunostaining was observed in the villous or intervillous areas of any of the placentas. In diabetic placentas the expression of hCG was homogeneous with a moderate to intense immunoreactivity in the syncytiotrophoblast. Several syncytiotrophoblast cells showed dilations of both rough and smooth endoplasmic reticulum and loss and alteration of microvilli, and large vacuoles were observed just below the plasma membrane, as well as irregularities in the mitochondria. Conclusion: Syncytial cells play an important role in the placental transition. Increased expression of ß- hCG, deterioration, degeneration of organelles and cell structure and the basal membrane disorder in chorionic vessels were seen in placentas with gestational diabetes. These changes can affect placental transfer. However, further studies are needed to clarify this issue. © Science Printers and Publishers, Inc.Öğe Nevoid hyperkeratosis of the nipple and areola: Case report(2001) Kilinç N.; Yaldiz M.; Yilmaz F.; Akdeniz S.; Özekinci S.Nevoid hyperkeratosis of the nipple and areola is a rare benign condition of unknown etiology, Its characteristic properties are verrucous thickening and brownish discoloration of the nipple and areola. In microscopic examination, hyperkeratosis, papillomatosis and acanthosis with keratotic plugging were observed and nevoid hyperkeratosis was diagnosed. We discussed this rare condition in the light of current literature.Öğe Primary alignant schwannoma of the small bowel(2001) Yilmaz F.; Uzunlar A.K.; Bükte Y.; Özekinci S.; Akgün Y.[No abstract available]
