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Öğe 2002-2007 yılları arasında Diyarbakır'da histopatolojik tanı alan kistik ekinokokkozis olgularının değerlendirilmesi(2009) Mızrak, Bülent; Özekinci, Selver; Bakır, ŞuleEkinokokkozis, Echinococus cinsi sestodların neden olduğu, insanlarda ve hayvanlarda kistler oluşturan paraziter bir hastalık olup ülkemizde önemli bir sağlık sorunudur. 2005-2007 yılları arasında histopatolojik tanı alan 234 kistik ekinokokkozis olgusu retrospektif olarak incelenmiş ve Diyarbakır yöresinde hastalığın topogrofik özellikleri ve yaygınlığı ile ilgili bilgi edinilmesi amaçlanmıştır. Hastaların raporlarındaki bilgiler temel alınarak, yaş, cinsiyet ve parazitin yerleştiği organlara göre değerlendirilmiş, aynı organa ait birden fazla materyali olan olgular bir kez değerlendirilmeye alınmıştır. Olguların %60,25'inin kadın, %39,74'ünün erkek olduğu saptanmıştır. Hastaların yaş ortalaması 27.01, kadınlarda 28.2, erkeklerde ise 25.3 olduğu görülmüştür. En fazla tutulumun %44,01 ile karaciğerde olduğu, akciğerin ise %31,19 ile ikinci sıklıkta tutulum gösterdiği izlenmiştir. Olguların özeliklerinin genel olarak literatür ile uyumlu olduğu ama literatüre göre daha erken yaşlarda tanı aldıkları izlenmiştir. Kistik ekinokokkozisin, Diyarbakır bölgesi için önemli bir halk sağlığı problemi olduğu görülmüştür. Uygun eradikasyon programların hazırlanması için güvenilir verilere ihtiyaç vardır.Öğe Adenomyomatous polyp causing acute urinary retention in a postmenopausal woman(Modestum Publishing Ltd., 2011) Evsen, Mehmet Sıddık; Sak, Muhammet Erdal; Soydinç, Hatice Ender; Gümüş, Hatice; Özekinci, Selver; Gül, TalipA case of adenomyomatous polyp (AP) causig acute urinary retention in postmenopausal period is presented. A 65-year-old, G8P8 women admitted to our clinic with the complaint of vaginal bleeding and vaginal mass was identified. During preoperative hospitalization she complained about not able to urinate. Serum urea and creatinine levels increased [66 mg/dL (range= 10-45) and 2,49 mg/dL (range= 0. 6-1.3) respectively]. Emergent abdominopelvic tomography showed vaginal mass and overdistended bladder. Mass was removed by vaginal route and abdominal hysterectomy was also performed. Pathologic examination revealed non-malignant AP with massive necrosis. A variety of female reproductive tract diseases can cause urinary obstruction. Treatment choice depends on reproductive expectance of the patient. J Clin Exp Invest 2011; 2 (3): 312-314.Öğe Böbrek leiomyomu: Olgu sunumu(2009) Uzunlar, Ali Kemal; Akgün, Işık İkbal; Gedik, Abdullah; Özekinci, SelverBöbrek leiomyomu, nadir görülen böbrekdeki düz kas hücrelerinden köken alan benign mezenkimal tümördür. Sıklıkla böbrek kapsülü ve pelvise yakın alanlarda yerleşir. Klinik semptomlar nonspesifiktir. Bu çalışmada, sol total nefrektomi yapılan bir hastadaki böbrek leiomyom olgusu rapor edilmektedir.Öğe Çok düşük frekanslı manyetik alanın ratlarda lens üzerine etkileri(Dicle Üniversitesi Tıp Fakültesi, 2008) Keklikçi, Uğur; Akpolat, Veysi; Özekinci, Selver; Ünlü, Kaan; Çelik, M. Salih; Tunik, SelçukBu çalışmanın amacı çok düşük frekanslı manyetik alanın (ELF MF) lens fibrilleri ve lens epitel hücreleri üzerine etkisini değerlendirmektir. Yirmi adet erişkin, dişi Spraque Dawley rat, her birisi 10 rattan oluşan 2 grupa ayrıldı. Deney grubu, günde 2 saat olmak üzere 7 gün ELF MF aldı. İkinci grup standart laboratuar şartlarına alınarak, kontrol grubu olarak kullanıldı. Materyaller lenste kataraktöz değişiklik ve lens epitel hücrelerinde histolojik değişiklikler yönünden değerlendirildi. Biomikroskopik muayenede lenste patoloji saptanmadı. Materyallerin mikroskopik incelemesinde, kontrol grubunda lens fibrilleri ve lens epitel hücrelerinde değişiklik saptanmadı. Deney grubunda ise yüzeyel epitel hücre konturlarında hafif pleomorfizm dışında patoloji saptanmadı. Çalışmada, ELF MF’nin lens fibrillerinde ve epitelinde belirgin bir histopatolojik değişikliğe yol açmayabileceği sonucuna varıldı.Öğe Comparison of morphological similarities and differences between liquid-based cytology and conventional techniques of serous effusion cytology specimens(Karger, 2022) Baykuş, Nurhan; Özekinci, Selver; Erdem, Zeynep Betül; Vurgun, Eren; Yıldız, Fetin RüştüIntroduction: The aim of this study is to discover a fast and efficient method for the diagnosis of serous effusion cytology specimens by comparing the cytomorphological features of SurePath (SP) smears and smears prepared by cytospin. After the macroscopic features of the incoming material were recorded, it was divided into 2 for conventional technique (CT) and liquid-based technique. Cytospin was used for CT and SurePath for liquid-based technique in this study. Materials and Methods: 243 serous effusions (33 thoracentesis and 92 paracentesis fluids, 118 peritoneal lavage fluids) were investigated. After shaking the effusion gently, it was centrifuged for 5 min at 1,250 rpm for cytospin smear. SP smear was prepared according to the "BD PrepStain slide processor". Two smears were prepared with these 2 methods and then stained with Papanicolaou. The smears were examined under a light microscope in terms of fixation, background, cellularity, nucleus, and structural features. All statistical analysis of the data was performed using the SPSS 17.0 software. For each microscopic feature, the chi(2) test was used to assess the significance of the relationship between cytospin and SP, and level of agreement in between the methods was assessed using the kappa statistic. Results: A statistically significant difference was observed between the 2 methods in background (p < 0.001), cellularity (p < 0.001), nucleus features (p < 0.001), and structural features (p < 0.05). There was no significant difference in fixation. Low level of agreement was observed with the kappa statistic in fixation, background, and cellularity. Moderate level of agreement was observed in the nucleus and structural feature groups with the kappa statistic. Discussion/Conclusion: Although there are advantages of liquid-based technique such as standardized fixation and cleaner background, since the cellular and background components required for morphological analysis and diagnosis are better preserved in cytospin, it is considered to be better to use liquid-based technique not alone but together with CT.Öğe Effects of melatonin and N-acetylcysteine on lung ischemia reperfusion injury(Bayrakol Medical Publisher, 2022) Durkan, Atilla; Çakmak, Muharrem; Ülkü, Refik; Özekinci, Selver; Kale, EbruAim: In our study, we aimed to determine the effects of using melatonin, N-acetyl cysteine, and low potassium dextran solution (LPDS) as a preservative solution on ischemia/reperfusion injury. Material and Methods: A total of 48 male Sprague-Downey rats were used. Rats were divided into 8 groups: group 1: ischemia, group 2: ischemia+melatonin, group 3: ischemia + N-acetylcysteine, group 4: ischemia+melatonin + N-acetylcysteine, group 5: ischemia + reperfusion, group 6: ischemia + reperfusion + melatonin, group 7; ischemia + reperfusion + N-acetyl cysteine, and group 8; ischemia+reperfusion+melatonin+N-acetyl cysteine. Total antioxidant capacity (TAOC), malondialdehyde (MDA) and neutrophil values of each group were determined. The TAOC was obtained by spectrophotometric measurement of the absorption level of the color formed by the hydroxylion formed by the Fenton reaction with orthodianisidine. The MDA value was obtained spectrophotometrically using the thiobarbituric acid method, and the Neutrophil count was obtained as cell count using Papanicolau Stain stain. Results: While the highest TAOC values were in groups 4, 2, 3, 1, the lowest TAOC values were in groups 5,7,6,8. The highest MDA values were in groups 5, 7, 6, 1, 8, whereas the lowest MDA were in groups 4, 2, 3 (p<0.05). Neutrophil in bronchoalveolar lavage increased in groups 5,7,6,3,2,8,4. Discussion: In lung ischemia reperfusion, the use of melatonin and/or N-acetyl cysteine, and LPDS decreases plasma MDA levels and increases TAOC values. Additionally, the use of these antioxidants and preservation solutions decreases cell damage immunohistochemically, the cytokines mediating inflammation, the PMNL, and the inflammatory response associated with them.Öğe Etiological factors and histopathological features in erythema nodosum: A 6-year retrospective cross-sectional study(Slovene Medical Society, 2021) Singer, Ralfi; Özekinci, SelverIntroduction: Erythema nodosum (EN) is the most common type of panniculitis. The most frequent etiological factors are streptococcal pharyngitis, sarcoidosis, Behçet’s disease, and tuberculosis. Our objective was to identify the etiological factors and to evaluate the patients’ clinical, laboratory, and histopathological findings. Methods: Eighty-eight patients diagnosed with EN at our clinic between 2013 and 2019 were evaluated retrospectively. Sixty-five patients were evaluated histopathologically. Results: The patients’ ages ranged between 17 and 76 (mean age: 41.91 ± 13.07 years). EN was 7.8 times more frequent in women. Patients presenting with idiopathic EN were significantly older than secondary cases (p < 0.05). Sixty-one patients (69.3%) had an underlying disease (secondary EN). The most common etiological factors were upper respiratory tract infections (n = 26), followed by Behçet’s disease (n = 20). Septal panniculitis was present in 89.2% of cases evaluated histopathologically. Mixed or lobular panniculitis was present in 35.7% of Behçet’s disease patients with EN-like lesions. Vasculitis was also noted in 35.7% of Behçet’s disease patients. Conclusions: Our data confirm the predominance of upper respiratory tract infections and Behçet’s disease among patients with EN in Turkey. Behçet’s disease patients presenting with EN-like lesions may show mixed panniculitis and vasculitis, whereas classic EN patients predominantly show septal panniculitis.Öğe Güneydoğu Anadolu Bölgesinde mezotelyoma tanlı olgularda tek merkez deneyimi(2009) Onat, Sedar; Güngör, Ateş; Şenyiğit, Abdurrahman; Zincircioğlu, Burhanettin; Işıkdoğan, Abdurrahman; Özekinci, Selver; Ülkü, RefikMezotelyoma seröz yüzeylerden kaynaklanan agresif seyirli bir tümördür. Sıklık sırasına göre plevra, periton, tunica vajinalis ve perikartdan kaynaklanır. Tüm dünyada mezoteloma için asbest fiberlerine maruziyet en önemli faktör iken daha nadir olarak radyasyon ve fibröz zeolit (erionite) diğer etyolojik faktörlerdir. Türkiye’de çevresel asbest maruziyeti bazı bölgelerde sıktır ve bu bölgelerde mezotelyoma sıklığı diğer bölgelerden belirgin olarak daha fazladır. Güneydoğu Anadolu bölgesi’de Türkiye’de çevresel asbest liflerine maruziyetin oldukça fazla olduğu bölgelerimizdendir. 2003-2007 yılları arasında Dicle Üniversitesi Tıbbi Onkoloji kliniğinde düzenli takip ve tedavileri yapılmış 45 malign mezotelyoma tanısı alan olgunun demografik özellikleri, uygulanan tedavi seçenekleri, uygulanan kemoterapi protokoleri ve tedavi yanıtları retrospektif olarak değerlendirildi. Olgular değerlendirildiğinde; hastalardan 13 (%28)’ünün şehir merkezinde yaşarken 32 (%72)’inin ise kırsalda yaşamakta olduğu saptandı. Yirmisekiz (%62.2) hastada plevral mezotelyoma saptanırken, 15 (%33.3) hastada peritoneal ve 2 (%4.5) olguda perikardial mezotelyoma saptandı. Platin-gemsitabine uygulanan gurupta tedavi yanıtı 6 (%20.6) olguda saptanırken, platin-pematraksat uygulanan gurupta tedavi yanıtı 5 (%31.25) olarak saptandı. Mesotelyoma Güneydoğu Anadolu bölgesinde diğer bölgelerden çok daha sık görülmektedir ve bu bölgede halen önemini korumaktadır. Mezotelyoma olgularında kemoterapi çoğunlukla palyatif amaçlı uygulanmaktadır. Ancak literatürdeki yanıt oranları yeni tedavi seçenekleri ile dahi oldukça düşük iken bizim olgularımızın tedavi yanıtları literatürden belirgin olarak daha düşüktür.Öğe Meme başı ve areolanın nevoid hiperkeratozu: Olgu sunumu(2001) Akdeniz, Sedat; Kılınç, Nihal; Yaldız, Mehmet; Özekinci, Selver; Yılmaz, Fahri[Abstract Not Available]Öğe Memede schwanoma: Olgu sunumu(2007) Yılmaz, Hatice Gülşen; Taçyıldız, İbrahim Halil; Korkmaz, Özgür; Akgün, Yılmaz; Özekinci, SelverSchwanoma, yavaş büyüyen bir tümör olup sıklıkla eksteremite, gövde ve baş bölgesinde rastlanır. Bu olgu sunumu ile 51 yaşında sağ memesinde benign Schwanoma tespit edilen bir olgu sunuldu. Sağ meme üst kadran lokalizasyonunda palpable kitlesi mevcuttu. Kitlenin total çıkarılması takiben patolojik inceleme sonucu schwnoma ile uyumlu tespit edildi.Öğe Paraganglioma of urinary bladder: A case report(Avrasya Üroonkoloji Derneği, 2023) Bıçak, Tuğçem; Özekinci, Selver; Bıçak, Yekta; Dağgülli, MansurObjective: The majority of bladder lesions are papillary and/or flat-appearing urothelial neoplasms. Neoplasms other than urothelial tumors are extremely rare. Paragangliomas are rare catecholamine-releasing tumors of sympathetic ganglion or chromaffin cell origin. Approximately 10% of paragangliomas occur in the non-adrenal region, of which 10% are seen in the bladder and constitute 0.05% of all bladder tumors. About 10% of paraganglioma occur in extra-adrenal sites, of which, 10% are located in bladder wall accounting for 0.05% of all bladder tumors. In a 42-year-old female patient, a mass on the anterolateral wall of the bladder, measuring 50x43 mm solid mass protruding into the lumen with necrotic center and increased vascularity on the periphery was reported. The specimens of the, transurethral resection bladder material obtained from an external center and our hospital were examined by pathology and diagnosed as paraganglioma. Because of its rarity and confusion with urothelial carcinoma, paraganglioma should always be recognized when dealing with bladder tumorsÖğe Patoloji arşivindeki 10 yıllık kanser (1991-2000) olgularının genel değerlendirilmesi(2016) Özekinci, Selver; Özaydın, MehmetDicle Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalında 1991- 2000 yılları arasında tanı verilen 71758 biyopsi raporu retrospektif olarak incelendi. Bunlardan kanser tanısı alan 4795 olgunun yaş, cinsiyet ve topografiye göre dağılımları incelendi. Veriler SPSS 10.0 istatiksel program paketi kullanılarak değerlendirildi. Kanser tanısı alan olguların 2698'inin (%56.3) erkek, 2097'si (%43.7) kadındır. Yıllara göre gelen biyopsi sayısındaki artışa bağlı olarak kanser tanısı alan olgu sayısı da artmıştır. Olgularda erkek/kadın oranı (E/K) 1.28'dir. Erkek hastalarda ortalama yaş 52.3, kadın hastalarda ortalama yaş 45.6 olarak tespit edildi. Her iki cinsde de kanserler 60 ve üstü yaşlarda en sık izlenmiştir. Toplam 345 (%7.1) olguda biyopsi materyalinin alındığı organ, doku ya da sistem, toplam 360 (%7.5) olguda da yaş tespit edilemedi. Erkeklerde, deri (%15.4), lenf nodu (%12.8), akciğer (%8.9) kanserleri ilk üç sırayı alırken kadınlarda ilk üç sırada deri (%15.9), meme (10.2) ve lenf nodu (%9.7), kanserleri izlendi. Her iki cinsde de deri kanseri ilk sırada izlenmektedir. Lenf nodu, akciğer ve mesane kanserleri de yüksek oranda izlenmektedir.Öğe Primary malignant Schwannoma of the small bowel(2001) Yılmaz, Fahri; Akgün, Yılmaz; Bükte, Yaşar; Özekinci, Selver; Uzunlar, Ali KemalSchwannomas arise from the Schwann cells that cover the peripheral nerves. Most of them are benign. Malignant schwannomas are most commonly seen in the proximal parts of the upper and lower extremities and trunk. A malignant schwannoma of the small intestine is an extremely rare disease. Only 24 cases have been reported in the English language medical literature. We report a case of a malignant schwannoma of the small intestine in a 53-year-old woman.Öğe Pulmonary hydatid disease in southeastern Anatolia, Turkey(Tubitak Scientific & Technological Research Council Turkey, 2010) Özekinci, Selver; Bakır, Şule; Uzunlar, Ali Kemal; Eren, ŞevvalAim: To evaluate retrospectively epidemiological parameters and clnicopathologic figures of pulmonary hydatid disease in our region. Materials and methods: A total of 117 cases of human pulmonary hydatid disease were included in this study, and these cases were diagnosed in the Department of Pathology of Dicle University Medical School, between 1987 and 2007 The patients' data were retrospectively collected from archival reports, in addition, some of the patients were still alive and contactable Results: Our 117 cases consisted of 66 (56 41%) females and 51 (43.58%) males The average age was 28 18 Pulmonary hydatidosis appears to be more common in younger individuals The prevalence is 2 6 cases/100,000 Of the total of 129 pulmonary cysts, there were 75 cysts on the right and 54 on the left side. The mean pulmonary hydatid cyst diameter in the 117 patients was 7.20 cm Conclusion: In our region, pulmonary hydatid disease appears to be more common in younger, female individuals, and the cysts also tend to be bigger in children than in adultsÖğe The similarities and differences between liquid-based and conventional methods in evaluation of thyroid fine needle aspiration cytologies(Wolters Kluwer Medknow Publications, 2023) Özer, Mehmet; Özekinci, SelverAims: Thyroid nodules are one of the most frequent medical issues in endocrinology in our country and around the world. The appropriate evaluation of the nodule is critical in the management of patients. Fine needle aspiration cytology (FNAC) is one of the most accurate tools for evaluating these nodules. Conventional and liquid-based (LB) methods are available for thyroid FNAC. In this paper, we aim to determine the best cytological method for the evaluation of thyroid fine needle aspiration materials. Settings and Design: Fine needle aspiration (FNA) materials obtained and prepared by conventional and LB methods from 310 patients were evaluated. These slides were compared in terms of 12 cytological parameters in a three-tiered system, and the kappa coefficient was calculated. Methods and Material: Two slides were prepared from FNA samples, and the rest of the material was left in protective solution for LB cytology. Surepath was used as a LB technique. Conventional slides (CS) were left to dry in the air and stained with May Grunwald Giemsa. Slides prepared by two different techniques were compared in 12 cytomorphological parameters, and Kappa coefficients and correlations were calculated. Statistical Analysis Used: Kappa statistics. Results: In comparison of LB and CS, the highest kappa coefficient was in chromatin texture (κ:0.738) and inflammatory cells (κ: 0.482). On other parameters, fair or poor agreement was observed. Conclusions: Although there are some superiorities to LB cytology, co-application of these two methods is more favorable in thyroid fine needle aspiration.Öğe TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides(John Wiley and Sons Inc, 2024) Örnek, Sinem; Özekinci, Selver; Ipin, Tuğba; Kocatürk, EmekBackground: Diagnosis of early mycosis fungoides (eMF) is challenging and often delayed as many of its clinical and histopathologic features may mimic various benign inflammatory dermatoses (BIDs). The products of the thymocyte selection-associated high mobility group box (TOX), twist family BHLH transcription factor 1 (TWIST1), signal transducer and activator of transcription 4 (STAT4), and special AT-rich sequence-binding protein 1 (SATB1) genes function as transcription factors and are involved in the pathogenesis of MF. Objectives: We aim to determine the diagnostic value of TOX, TWIST1, STAT4, and SATB1 protein expressions in eMF. Methods: This non-randomized, controlled, prospective analytic study was conducted by performing immunohistochemistry staining with TOX, TWIST1, STAT4, and SATB1 polyclonal antibodies in lesional skin biopsies of eMF and BID patients. Nuclear staining of lymphocytes was compared between eMF and BIDs, and the capacity of these antibodies to predict eMF was determined. Results: Immunostainings with anti-TWIST1 showed an increase in protein expression (p = 0.003) and showed a decrease with anti-SATB1 antibodies in eMF compared to BIDs (p = 0.005) while anti-TOX and anti-STAT4 antibodies did not exhibit significant differences (p = 0.384; p = 0.150). Receiver operating characteristic analysis showed that immunohistochemical evaluations of TWIST1 and SATB1 protein expressions can differentiate eMF (area under the curve [AUC]: 0.728, 95% confidence interval [CI]: 0.605–0.851, p = 0.002; AUC: 0.686, 95% CI: 0.565–0.807, p = 0.013). Conclusions: TWIST1 and SATB1 are potential diagnostic markers for the histologic diagnosis of eMF.
