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Öğe Analysis of the albumin level, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio in Guillain-Barré syndrome(Associacao Arquivos de Neuro-Psiquiatria, 2016) Özdemir, Hasan HüseyinThe purpose of this study was to investigate the prognostic value of the pretreatment and post-treatment albumin level, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in subtypes of Guillain-Barré syndrome (GBS). A retrospective analysis of 62 patients with GBS treated between 2011 and 2015 in Dicle University Hospital, Turkey, was carried out. The pretreatment and post-treatment albumin, NLR, and PLR were documented, together with acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy, motor sensory axonal neuropathy, and Hughes’ scores. Post-treatment albumin levels in GBS were significantly reduced, and albumin level was negatively correlated with the Hughes scores. Elevated pretreatment NLRs and PLRs were significantly associated with AIDP. There were no correlations between the Hughes scores, NLR, and PLR. The results point to a negative correlation between albumin levels and GBS disability and suggest that the NLR and PLR may be promising blood biomarkers of AIDP.Öğe Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension(Associacao Arquivos de Neuro-Psiquiatria, 2022) Dündar, Ahmet; Arıkanoğlu, Adalet; Özdemir, Hasan Hüseyin; Aslanhan, Hamza; Çevik, Mehmet UğurBackground Idiopathic intracranial hypertension (IIH) is characterized by increased cerebrospinal fluid (CSF) pressure of unknown cause. It has been suggested that the inflammatory process plays a role in the pathophysiology of the disease. Sortilin-1, lipocalin-2, autotaxin, decorin, and interleukin-33 (IL-33) are among the factors involved in inflammatory processes. Objective To investigate the CSF levels of sortilin-1, lipocalin-2, autotaxin, decorin, and IL-33 in patients with IIH. Methods A total of 24 IIH patients and 21 healthy controls were included in the study. Demographic characteristics of the patients and of the control group as well as CSF pressures were evaluated. Sortilin-1, lipocalin-2, autotaxin, decorin and IL-33 levels in the CSF were measured. Results The CSF levels lipocalin-2, sortilin-1, autotaxin, IL-33 and CSF pressure were significantly higher in the patients group compared with the control group (p < 0.001). Decorin levels were reduced in patients (p < 0.05). There was no correlation between the autotaxin and IL-33 levels and age, gender, CSF pressure, and body mass index. The results of our study showed that inflammatory activation plays an important role in the development of the pathophysiology of IIH. In addition, the fact that the markers used in our study have never been studied in the etiopathogenesis of IIH is important in explaining the molecular mechanism of this disease. Conclusion Studies are needed to evaluate the role of these cytokines in the pathophysiology of the disease. It is necessary to evaluate the effects of these molecules on this process.Öğe Determination of the effects on learning and memory performance and related gene expressions of clothianidin in rat models(SPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS, 2014) Özdemir, Hasan Hüseyin; Kara, Murat; Yumrutaş, Önder; Üçkardeş, Fatih; Eraslan, Ersin; Demir, Caner F.; Bal, RamazanClothianidin (CLO) is one of the pesticides used to protect against insects, and its potential toxic effects on cognitive functions are not clearly known. This study aims to evaluate the possible effects of dose-dependent CLO on learning and memory in infant and adult male rats and the expression of related genes in the hippocampus. Doses of 2, 8 and 24 mg/kg of CLO were administered to newborn infant and adult albino Winstar rats in the form of gavage and dissolved in vehicle matter. Their cognitive and learning functions were evaluated by the Morris water maze and probe tests. Expression levels of N-methyl D-aspartate 1 (GRIN1), muscuranic receptor M1, synoptophysin (SYP) and growth-associated protein 43 (GAP-43) of tissues isolated from the hippocampus were determined using the real-time PCR method. In the Morris water maze test, no change (p > 0.05) was exhibited in the adult and infant rats after CLO was applied, although there was a significant difference (p < 0.05) in performance between infants and the control group after 24 mg/kg was applied in the probe test. Also, expression levels GRIN1, M1, SYP, GAP-43 did not change when compared to the control (p > 0.05). Our study shows that exposure to high doses of CLO causes deterioration of cognitive functions in infant rats.Öğe Effects of memantine and clopidogrel alone and in combination in a cerebral ischemia-reperfusion model(Elsevier B.V., 2015) Özdemir, Hasan Hüseyin; İlhan, Selçuk; Demir, Caner Feyzi; Akgün, Bekir; Kapan, Oktay; Ataş, Eser; Berilgen, Muhammed SaidThere are many factors in cerebral ischemia that cause cell death. Glutamate receptor-mediated neurotoxicity is the major mechanism involved in hypoxic-ischemic brain injury (HIBI). Memantine is a low affinity, non-competitive NMDA antagonist blocker, while clopidogrel is an antiplatelet agent used in the treatment of ischemic stroke. The aim of this study is to investigate the effects of clopidogrel and memantine (alone and in combination) on HIBI. Thirty-five Sprague-Dawley rats were exposed to hypoxia for 10 min by ligation of the bilateral common carotid artery. Following this, the rats were divided equally into groups as follows: control, ischemia, memantine (IM), clopidogrel (IC) and memantine + clopidogrel (IMC). Drug therapy was administered for a period of five days, after which all rats were sacrificed and malondialdehyde (MDA), total antioxidant status (TAS), total oxidant (TOS) values, and oxidative stress index (OSI) were determined in brain tissue. MDA and TOS values were significantly higher in the group that underwent ischemia than in the control group. MDA, TOS and OSI values were significantly lower in the groups treated with IM, IC, or IMC than in the group that underwent ischemia. Although it was not significant, TOS and OSI were lower in the groups that underwent combined treatment than in the groups that underwent treatment with IM or IC alone. Our results indicate that memantine and clopidogrel treatment, when used individually, reduce oxidative stress in HIBH more so than when these treatments are combined. This may be due to potential pharmacokinetic mechanisms of the combined therapy.Öğe Efficacy of peripheral lidocaine application (neural therapy) in the treatment of neurogenic detrusor overactivity in multiple sclerosis patients(Wiley, 2017) Tamam, Yusuf; Özdemir, Hasan Hüseyin; Gedik, Abdullah; Tamam, Cüneyt; Nazlıkul, HüseyinAimsMany agents and treatments are used in the treatment of neurogenic detrusor overactivity (NDO) in MS patients, but no study has been conducted on the use of peripheric lidocaine (neural therapyNT) on MS patients. We evaluated the effects of local administration of lidocaine on NDO in Multiple Sclerosis (MS) patients. MethodsFor each patient local anesthetic lidocaine was injected at each session. Sessions were held once a week for 5 weeks. At each session, Th 10-L1, urogenital segment intradermal injections, Frankenhauser, and sacral epidural injections were given. The patients had clinical and urodynamic assessment 1 month before and 3, 9, and 12 months after NT. In addition, multiple sclerosis quality of life inventory (MSQL-54) and bladder control scale (BLCS) was performed for patients. ResultsTwenty-eight patients were included in the study (8 males, 20 females). The patients' average age was 31.78.1 years. The injection therapy significantly improved volume at first involuntary bladder contraction (FCV), maximal detrusor pression during filling (P det. max.), maximal cystometric bladder capacity (MCC) after 3 months. Also, the MSQL-54 and BLCS scores were improved with treatment. However, these improvements reached a maximum 3 months after treatment, but from the 9 month a regression was seen in the parameters, and after 12 months the findings were seen to be slightly above their basal levels. ConclusionsThese results suggest that NDO treatment in MS patients could be an effective treatment which is easy and has very few side effects, and is cost effective.Öğe Increased visinin-like protein-1, YKL-40, lipocalin-2, and IL-23 levels in patients with migraine(Taylor and Francis Ltd., 2023) Dündar, Ahmet; Cafer, Vugar; Aslanhan, Hamza; Özdemir, Hasan Hüseyin; Yılmaz, Ahmet; Çevik, Mehmet UğurBackground: Migraine is a type of primary headache caused by changes in the trigeminal system and has been reported to be associated with neurovascular inflammation of cerebral and extracerebral vessels.Objective: It is known that inflammation is an important process in the pathogenesis of migraine. It has been shown that the molecules of visinin-like protein 1 (Vilip-1), YKL-40, lipocalin-2 and interleukin (IL)-23 play a role in the inflammatory process. Our aim is to investigate the role of this molecule in the metabolic pathway of migraine disease.Methods: Fifty migraine patients with and without aura in the interictal period were included in the study. Vilip-1, YKL-40, lipocalin-2, and IL-23 levels were measured by ELISA method.Results: Serum vilip-1, YKL-40, lipocalin-2, and IL-23 levels were found to be significantly higher in migraine patients compared to the control group. We found that this molecule increased significantly in migraine subgroups compared to the control group (p < 0.001). A positive significant correlation was found between vilip-1 level and YKL-40 and lipocalin-2 levels in migraine patients. In addition, a positive correlation was observed between visual analogue scale score, number of days with pain and vilip-1 level (p < 0.01). The results of our study showed that activation of inflammatory mediators may play a role in the pathogenesis of migraine disease. In addition, our study is valuable in that inflammatory molecules are high in the interictal period and these biomarkers have never been analyzed in migraine patients. However, we still believe that larger studies are needed to explain the role of vilip-1, YKL-40, lipocalin-2, and IL-23 in the molecular mechanism of migraine disease.Öğe İskemik inmenin akut ve subakut döneminde matriks metalloproteinaz-2 ve matriks metalloproteinaz-9 düzeylerinin değerlendirilmesi(Dicle Üniversitesi Tıp Fakültesi, 2016) Varol, Sefer; Çevik, Mehmet Uğur; Acar, Abdullah; Demirpençe, Özlem; Kaplan, İbrahim; Taşdemir, Nebahat; Özdemir, Hasan HüseyinAmaç: Ateroskleroz ve inflamatuar mekanizmalar serebral iskemi patogenezinde önemli bir rol oynamaktadırlar. Matriks metalloproteinazların (MMP) aktivitesi inflamatuar hücrelerin infiltrasyonu, düz kas hücre migrasyonu ve proliferasyonu gibi aterosklerotik plak oluşumu ile ilişkili birçok süreçte gereklidir. MMP-2 ve MMP-9 serum düzeylerinin akut iskemik inmede inme şiddeti ve prognoz açısından önemini araştıran az çalışma vardır. Bu çalışmada iskemik inmeli hastaların akut ve subakut dönemdeki MMP-2 ve MMP-9 seviyeleri ve Glasgow Koma Skalası (GKS) ile bu biyokimyasal parametrelerin ilişkisi değerlendirildi. Yöntemler: Çalışmaya prospektif olarak akut dönem başvuran iskemik inmeli 64 hasta dahil edildi. İskemik inmeli bu hastaların akut ve subakut dönemlerinde serum MMP2 ve MMP-9 antikor düzeyi ELİSA yöntemi ile ölçüldü. Bulgular: Akut dönemde serum MMP-2 ortalama değerleri 4,28 ±3,36 ng/mL, subakut dönemde ise 2,27 ± 2,62 ng/mL idi (p˂0,05). Ayrıca akut dönemde MMP-9 ortalama değeri 2,83 ± 3,83 ng/mL subakut dönemde 2,27 ± 1,57 ng/mL idi (p˃0,05). MMP-2 ve MMP-9 seviyeleri ile hastaların GKS arasında korelasyon saptanmadı. Sonuç: Bu sonuçlar MMP-2 düzeyi iskemik inmeli hastaların akut döneminde subakut döneme göre yüksek olduğunu gösterir. Bu nedenle MMP-2 düzeyi iskemik inmenin patogenezinde akut dönemde rolünü destekleyebilir.Öğe Karotis arter stentlemesi: İnvaziv bir üçüncü basamak merkez deneyiminin retrospektif değerlendirilmesi(Dicle Üniversitesi Tıp Fakültesi, 2016) Ertaş, Faruk; Çevik, Mehmet Uğur; Aluçlu, Mehmet Ufuk; Acet, Halit; Özdemir, Hasan Hüseyin; Karahan, Oğuz; Polat, Nihat; Aktaş, GülsenemAmaç: Karotis arter stentleme (KAS), karotis endarterektomi (KEA) tedavisine alternatif tedavi şekli olarak günümüzde giderek daha sık uygulanmaktadır. Bu çalışmada kliniğimize başvuran, karotis arter hastalığı tanısı konulan ve KAS ile revaskülarize edilen hastaların kısa vadeli klinik sonuçlarını sunmayı amaçladık. Yöntemler: Tek merkezli, geriye dönük Haziran 2013- Ocak 2016 tarihleri arasında karotis artere müdahale gerekliliği olan ve KAS işlemini kabul eden hastalar çalışmaya dahil edildi. Hastanın klinik özellikleri ve işlem ile ilgili verileri hasta dosyaları taranarak elde edildi. Daha sonra taburculuk sonrası hastanın yaşayıp yaşamadığı ve işlem sonrası yeni inme geçirip geçirmediği hastane kayıtlarından ve/veya telefon ile öğrenildi. Bulgular: Dahil edilme kriterlerini sağlayan 82 hasta çalışmaya alındı. Hastaların %59’i erkek olup, yaş ortalaması 68±9 yıl olarak saptandı. Hastaların %56’sı semptomatik idi. Bütün hastalara stent takıldı, %85 hastaya distal emboli koruyucu cihaz, %15’inde de MOMA yöntemi kullanıldı. İşlem ile ilişkili olarak 64 hastaya sağ, 18 hastaya sol ve 2 hastaya iki taraflı olmak üzere 82 hastaya toplamda 84 başarılı KAS işlemi yapıldı. Sadece 1 hastaya rezidü darlık nedeniyle ikinci stent yerleştirme ihtiyacı oldu. İşlemle ilişkili sadece 1 hastada 24 saate tamamen düzelen hava embolisine bağlı 2 hastada fazla opak alımına bağlı 24 saat sonra tamamen düzelen kontrast nörotoksisitesi oldu. Sonuç: Deneyimli merkezlerde KAS başarılı bir şekilde uygulanmakta olup komplikasyon riski oldukça düşüktür. KAS’ın orta vadeli klinik sonuçları oldukça yüz güldürücüdür.
