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    The Investigation of Protective Effect of Quercetin in Rats Exposed to Oxidative Stress by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
    (2019) Özdemir, İlknur; Çakır, Oğuz
    In this study, 28 Wistar Albino male rats were randomly divided into four equal groups. 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) was intraperitoneally administered at the dose of 2 µg/kg/week, quercetin was administered at the doseof 20 mg/kg/day by gavages, and quercetin+TCDD were intraperitoneally administered at the doses of 20 mg/kg/day and2 µg/kg/week, respectively. All applications were performed for 8 weeks. At the end of the eighth week, the rats weresacrificed and their heart and vascular tissues were taken for biochemical analysis (reduced glutathione (GSH), glutathioneperoxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD) and thiobarbituric acid reactive substance (TBARS) levels)by spectrophotometric method. As a result of the study, TCDD significantly decreased antioxidant activities and increasedlipid peroxidation in rats. In contrast, quercetin significantly prevented the toxic effects of TCDD via increasing SOD, CAT,GSH and GSH-Px levels but decreased the formation of TBARS. Therefore, it can be suggested that quercetin has thepotential for treatment against the toxicity caused by TCDD or other environmental contaminants and can decrease the riskof mortality due to cardiovascular diseases, especially in humans