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    Multicenter hospital-based prospective surveillance study of bacterial agents causing meningitis and seroprevalence of different serogroups of Neisseria meningitidis, Haemophilus influenzae Type B, and Streptococcus pneumoniae during 2015 to 2018 in Turkey
    (American Society for Microbiology, 2020) Ceyhan, Mehmet; Özsürekçi, Yasemin; Başaranoglu, Sevgen Tanır; Gürler, Nezahat G.; Salı, Enes; Emiroglu, Melike; Öz, Fatma Nur; Belet, Nurşen M.; Duman, Murat; Ulusoy, Emel; Kurugöl, Zafer; Tezer, Hasan; Parlakay, Aslınur Özkaya; Dinleyici, Ener Cagri; Çelik, Ümit Sizmaz; Çelebi, Solmaz; Öner, Ahmet Faik; Solmaz, Mehmet Ali; Karbuz, Adem; Hatipoglu, Nevin; Devrim, İlker; Caglar, İlknur; Bozdemir, Şefika Elmas; Kocabaş, Emine; Gündeşli·oğlu, Özlem Özgür; Sütçü, Murat; Akcan, Özge Metin; Kuyucu, Necdet; Aktar, Fesih; Kara, Soner Sertan; Akışoğlu, Havva Özlem Altay; Tuygun, Nilden; Uslu, Zeynep Diyar Tamburaci; Öncel, Eda Karadag; Bayhan, Cihangül; Cengiz, Ali Bülent
    The etiology of bacterial meningitis in Turkey changed after the implementation of conjugated vaccines against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) in the Turkish National Immunization Program (NIP). Administration of Hib vaccine and PCV-7 (7-valent pneumococcal conjugate vaccine) was implemented in NIP in 2006 and 2009, respectively. In 2011, PCV-7 was replaced with PCV-13. Meningococcal vaccines have not yet been included in Turkish NIP. This prospective study comprised 27 hospitals located in seven regions of Turkey and represented 45% of the population. Children aged between 1 month and 18 years who were hospitalized with suspected meningitis were included. Cerebrospinal fluid (CSF) samples were collected, and bacterial identification was made according to the multiplex PCR assay results. During the study period, 994 children were hospitalized for suspected meningitis, and Hib (n = 3, 2.4%), S. pneumoniae (n = 33, 26.4%), and Neisseria meningitidis (n = 89, 71%) were detected in 125 samples. The most common meningococcal serogroup was MenB. Serogroup W comprised 13.9% (n = 5) and 7.5% (n = 4) of the meningococci in 2015 to 2016 and 2017 to 2018, respectively. Serogroup C was not detected. There were four deaths in the study; one was a pneumococcus case, and the others were serogroup B meningococcus cases. The epidemiology of meningococcal diseases has varied over time in Turkey. Differing from the previous surveillance periods, MenB was the most common serogroup in the 2015-to-2018 period. Meningococcal epidemiology is so dynamic that, for vaccination policies, close monitoring is crucial.