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    Effects of nimodipine and ofloxacin on staphylococcal brain abscesses in rats
    (Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1997) Ceviz, A; Inalöz, SS; Çiçek, R; Sari, I; Gül, K; Sanli, A
    The therapeutic effects of nimodipine (GAS 66085-59-4) and ofloxacin (GAS 82419-36-1) were investigated against experimental brain abscess formation in rats. Nimodipine, a 1,4-dihydropyridine derivative, is chemically related to nifedipine but the smooth muscle relaxant effect preferentially acts on cerebral arteries. Ofloxacin is a member of 4-Quinolone broad spectrum antibiotics. Ninety-six male Sprague-Dawley rats were inoculated intracortically with Staphylococcus aureus and then different groups were treated with either saline. ofloxacin or the combination of ofloxacin and nimodipine. The rate of brain abscess formation and mortality were considerably decreased by nimodipine and ofloxacin therapy. Combination therapy was found histologically to be considerably more effective than ofloxacin alone against brain abscess formation in rats.