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    The diagnostic efficacy of low-dose cervical and thoracic CT in multiple trauma patients
    (Dicle Üniversitesi Tıp Fakültesi, 2013) Göya, Cemil; Yavuz, Alpaslan; Hamidi, Cihad; Andiç, Çağatay; Çetinçakmak, Mehmet Guli; Teke, Memik; Özkaynak, Can
    Objective: The aim of this study was to evaluate the initial diagnostic efficacy of low-dose computed tomography (CT) in multi-trauma patients. Methods: 74 patients (44 male, 30 female; average age: 36.9 years) accepted to the emergency unit with the reason of multiple trauma which is included in this study. Cervical and thoracic injury sites were initially evaluated with portable X-Ray and low-dose CT. The Patients’ progress, surgical findings and additional radiologic examination results were recorded until the patients were discharged. Results: The sensitivity and specificity of X-Ray graphies were 50% and 95% for thoracic traumatic pathologies; 0-40% and 95-100% for cervical injuries respectively. CT examination sensitivity and specificity values were 95-100% and 80-100% for thoracic injuries; 95-100% and 96-100% for cervical injuries respectively. Conclusion: Low-dose CT examination is more sensitive than X-Ray graphs for the evaluation of cervicothoracic traumatic injuries. We recommend to prefer low-dose CT as an initial radiologic examination for managing cervicothoracic trauma cases because of its higher diagnostic capability than X-Ray graphy.
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    The relationship between oxidative stress markers and 1H-Magnetic resonance spectroscopy findings in obsessive compulsive disorder
    (Elsevier B.V., 2024) Turgut, Fatma Subaşı; Bulut, Mahmut; Hattapoğlu, Salih; Güneş, Mehmet; Kaya, Mehmet Cemal; Ekici, Faysal; Çetinçakmak, Mehmet Guli
    Introduction: The purpose of this study was to examine N-acetyl aspartate (NAA)/creatine (Cr) and glutamate, glutamine, and gamma-aminobutyric acid complex (Glx)/Cr levels in patients with obsessive compulsive disorder (OCD) and healthy controls’ orbitofrontal cortex (OFC) and caudate nucleus (CN) by proton magnetic resonance spectroscopy (1H-MRS) method and to investigate their relationship with oxidative stress markers glutathione peroxidase (GPx) and superoxide dismutase (SOD). Methods: This study included patients with OCD (n = 25) and healthy controls (n = 25) ranging in age from 18 to 65. We used the ELISA method to evaluate serum SOD and GPx levels. Levels of NAA/Cr and Glx/Cr in the orbitofrontal cortex and caudate nucleus were measured using the 1H-MRS method. Results: Our study did not detect statistically significant differences in the orbitofrontal cortex Glx/Cr and NAA/Cr levels between the OCD patients and the control group. OCD patients exhibited a decrease in NAA/Cr levels, consistent with impaired neuronal integration, and an increase in Glx/Cr levels, consistent with hyperactivation, in the caudate nucleus compared to the control group. We observed a negative correlation between NAA/Cr levels in the caudate nucleus and the levels of SOD and GPx. Conclusions: Our study is the first to assess CN and OFC together in OCD patients using 3 T MR, investigating the relationship between neurometabolite concentrations and oxidative stress parameters. The negative correlation we observed between NAA/Cr levels and SOD and GPx in the caudate nucleus suggests that increased oxidative stress in this brain region in OCD patients may contribute to impaired neuronal integration and functionality. © 2024 Elsevier B.V.
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    Relationship between pituitary siderosis and endocrinological disorders in pediatric patients with beta-thalassemia
    (Cureus Inc., 2021) Yılmaz, Kamil; Kan, Ahmet; Çetinçakmak, Mehmet Guli; Uzel, V. Hülya; Yılmaz, Deniz; Deniz, Muhammed Akif; Hattapoğlu, Salih
    Introduction Excess iron accumulation occurs mainly in organs such as reticuloendothelial cells, the pituitary gland, and the pancreas in beta-thalassemia because of blood transfusions. In the present study, it was aimed to investigate the relationship between T2* values on magnetic resonance imaging (MRI) and clinically diagnosed pituitary endocrinological disorders in children with thalassemia major. Methods This study enrolled patients diagnosed with beta-thalassemia at pediatric hematology outpatient clinics. In the study, in addition to the medical history of the patients, routinely performed tests, including hemoglobin electrophoresis, routine biochemical tests, and tests for pubertal development (follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, testosterone, etc.), as well as iron deposition measured by hepatic MRI T2* (STAR) sequence, were retrospectively assessed. A total of 29 patients were enrolled. Results Hypothyroidism was detected in 34.6% (9/26) of patients, short stature in 37% (10/27), and pubertal retardation in 50% (14/28) of the patients. There was no significant correlation between hypothyroidism and pituitary MRI T2* values. No significant correlation was found between laboratory parameters and pituitary MRI examination. Although the sensitivity of T2* levels could rise above 80%, their specificity remained low. This is one of the major limitations of the pituitary MR T2* study for the prediction of short stature. The best lower cut-off level of MR T2* to predict short stature was found 14.6 ms. Conclusion The diagnostic specificity pituitary MR examination levels for short stature were detected as low. Thus, the clinical standardization and validation of pituitary MR T2* values examination are needed before clinical follow-up and multifaceted studies are needed.