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Öğe 6-(1-Oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone inhibits lewis lung cancer by antiangiogenesis and apoptosis(Wiley-Liss, 2008) Çelik, Yusuf[Abstract Not Available]Öğe Acute appendicitis in pregnancy - risk factors associated with principal outcomes: A case control study(2007) Yılmaz, Hatice Gülşen; Akgün, Yılmaz; Baç, Bilsel; Çelik, Yusuf; 0000-0003-2849-4033Background: The aim of this study was to determine the risk factors associated with the principal outcomes in acute appendicitis during pregnancy: appendix-perforation, and maternal and fetal mortality and maternal morbidity. Methods: Fifty-two pregnant women who were diagnosed and operated upon acute appendicitis in Dicle University Hospital, Diyarbakir, Turkey were presented. Results: The frequency of appendicitis was higher in second trimester. On laparotomy 21 patients had perforated, 29 patients had non-perforated and 2 patients had normal appendix. Interval between symptom onset and operation was found as the only predictive variable, which was independently associated with the presence of appendiceal perforation. There was a significant difference between perforated and non-perforated patients about the rate of complications (52% vs. 17%). Gestational age (p = 0.036), interval between symptom onset and operation (p = 0.018) and white blood cell count (p = 0.025) were the variables related with preterm labor. Tocolytic treatment after the onset of contractions could not prevent preterm labor. The rate of fetal mortality was 8%. Conclusions: Presence of perforation is the only predictive factor for maternal morbidity. The aim of the surgeon should be operating the patient before perforation. An observation period may be essential in equivocal patients, but should be individualized according to duration of symptoms and findings of physical examination. The interval between the symptom onset and operation should never exceed 20 hours. Tocolytics should be ordered for the patients with delayed presentation and advanced gestational age in order to prevent preterm labor and fetal loss.Öğe Comparison of local and systemic ibuprofen for relief of postoperative pain in symptomatic teeth with apical periodontitis(International Scientific Information, Inc., 2022) Uysal, İbrahim; Eratilla, Veysel; Topbaş, Celalettin; Ergül, İsmail; Çelik, YusufBackground: One of the aims of endodontic treatment is to control preoperative and postoperative pain. The present study evaluated the effects of local and systemic ibuprofen on postoperative pain. It aimed to determine the most effective method for relieving postoperative pain due to chemomechanical preparation. Material/Methods: Ninety patients with symptomatic apical periodontitis were randomly assigned to local ibuprofen, systemic ibuprofen, and control groups (n=30 each). Chemomechanical preparations were performed using a ProTaper Universal Ni-Ti rotary file under 2.5% sodium hypochlorite and 17% ethylenediaminetetraacetic acid irrigation. After the root canals were dried with sterile paper points, while Odontocide paste was applied into the root canals of the patients in the local ibuprofen group, calcium hydroxide paste was applied into the root canals of the patients in the systemic ibuprofen and control groups. Following completion of the endodontic treatment procedure, 200 mg ibuprofen was prescribed to patients in the systemic ibuprofen group. Friedman and Wilcoxon tests were used for statistical analysis. Results: Posttreatment pain scores were recorded at 6, 12, 24, and 48 h using a visual analogue scale. Although there were no significant differences between the local ibuprofen group (Odontocide) and the control group (Ultracal) (P>0.05), pain scores in the systemic group (Ultracal+200 mg ibuprofen) were significantly lower than those in the other 2 groups (P<0.05). Conclusions: These results indicate that systemic administration of ibuprofen is effective for postoperative pain relief.Öğe The effects of long-term exposure to extremely low-frequency magnetic fields on bone formation in ovariectomized rats(Wiley, 2012) Çelik, Mustafa Salih; Gür, Ali; Akdağ, Zülküf; Akpolat, Veysi; Güven, Kemal; Çelik, Yusuf; Saraç, Aysegül Jale; Otçu, Selçuk; 0000-0002-2435-7800; 0000-0002-0181-3746; 0000-0003-2849-4033The effects of long-term extremely low-frequency magnetic field (ELF-MF) exposure on bone formation and biochemical markers were investigated in ovariectomized rats. Sixty mature female SpragueDawley rats were randomly divided into four different groups (n?=?15): (i) unexposed control (CTL); (ii) ovariectomized only (OVX); (iii) non-ovariectomized, exposed (SHAM?+?ELF-MF); and (iv) ovariectomized, exposed (OVX?+?ELF-MF). The third and fourth groups were exposed to 1.5?mT ELF-MF for 4?h a day for 6 months. Bone mineral density (BMD) was determined using dual energy X-ray absorption (DEXA) measurements. The formation and resorption of bone were evaluated using bone-specific alkaline phosphatase (BAP), osteocalcin, osteoprotogerin, and N-telopeptide. After 6 months of ELF-MF therapy, BMD values were significantly lower in the OVX group and higher in the OVX?+?ELF-MF and SHAM?+?ELF-MF groups than they were before therapy (P?Öğe An experimental study on the effect of platelet-rich plasma application on skin graft healing(Ortadoğu Reklam Tanıtım Yayıncılık, 2022) Gülsün, Niyazi; Akkoç, Mehmet Fatih; Kapı, Emin; Selçuk, Caferi Tayyar; Bozkurt, Mehmet; Akpolat, Veysi; Çelik, Yusuf; Alabalık, Ulaş; Yıldız, İsmailObjective: There is new information increasingly added about wound healing, which is one of the most complex physiological processes. In this study, it is aimed to evaluate the effect of plateletrich plasma on the wound healing process in pursuit of creation of skin defect on the back skin of the rat and application of graft to it. Material and Methods: The study was planned on 30 randomly selected inbred Sprague-Dawley rats. In the rats in the experimental group, 3x2 cm full-thickness skin defect was created after the back area was shaved. The skin taken from the defected area was thinned and turned into a full-thickness skin graft and sutured again to the area where it was taken. Platelet-rich plasma was applied under the graft to the rats in the 1st group, and physiological saline was applied to the 2nd group. The 3rd group did not undergo any surgical procedure, and it was created as the control group. Results: Significant differences were observed in glucose, lactate, glycerol, and pyruvate values in the tissue in Group 1, compared to other groups. In the histopathological evaluation, a significant decrease was detected in the rate of inflammation and edema in the Group 1, in comparison with the other groups. Conclusion: Based on the data obtained from this study, it was taken into consideration by us that platelet-rich plasma application is a method that can be applied in addition to the classical wound care, especially in the cases with wound healing problems.Öğe Farklı antiglokomatöz ilaçların uzun süreli kullanımının oküler yüzeye olan etkisinin karşılaştırılması(1999) Ünlü, Kaan; Çelik, Yusuf; Aksünger, Ahmet; Karakaş, Nurettin; Nergiz, YusufAMAÇ: Uzun süre topikal antiglokomatöz ilaç kullanan hastalarda gözyaşı film tabakası ve konjunktiva sitolojisinde oluşan değişikliklerin araştırılması amaçlanmıştır. GEREÇ VE YÖNTEM: En az bir yıl timolol, timolol + pitokarpin (kombine) veya pilokarpin kullanan toplam 32 hastanın 54 gözüne Schirmer I, gözyaşı kırılma zamanı testleri ve konjunktiva sitolojik baskısı uygulanmıştır. Sitolojik örneklerde goblet hücre sayımı yapılarak epitel hücre morfolojisi değerlendirilmiştir. Sonuçlar kontrol grubu ile karşıtaştınlmıştır. BULGULAR: Uzun süre pilokarpin kullanımının gözyaşı fonksiyon testleri üzerine, goblet hücre yoğunluğuna ve epitel morfolojisi üzerine belirgin bir etkisi saptanmadı. Timolol ve kombine ilaç kullanımının ise gözyaşı fonksiyon testlerinde ve goblet hücre yoğunluğunda önemli derecede azalmaya ve skuamöz metaplaziye neden olduğu görüldü. SONUÇ: Uzun süre antiglokomatöz ilaç kullanan hastalarda konjunktivadaki değişiklikler açısından pilokarpinin timolol ve kombine tedaviye oranla daha az yan etkiye neden olduğu gözlenmiştir.Öğe Hastane personelinin kan bağışı hakkındaki bilgi, tutum ve davranışlarının çok değişkenli lojistik regresyon yöntemiyle incelenmesi(2005) Çelik, Yusuf; Akkuş, Zeki; Sanisoğlu, Yavuz; Daşdağ, M. Mutlu; Satıcı, ÖmerTek değişkenli çözümlemeler yerine çok değişkenli çözümlemelerin yaygınlaştığı günümüzde bu yöntemlerin en çok uygulandığı alanlardan birisi de sağlık konusudur. Bu çalışma ile sağlık alanında lojistik regresyon çözümlemesinin tanıtımı yanında sağlık alanında bir uygulamanın da sunumu amaçlanmaktadır. Lojistik regresyon yönteminin bir uygulaması olarak Dicle Üniversitesi Tıp Fakültesinde görev yapmakta olan akademik personel ve diğer sağlık personelinden toplam 462 kişilik çalışma grubuna kan bağışı hakkındaki bilgi, tutum ve davranışlarını sorgulamak amacıyla 21 sorudan oluşan bir anket formu uygulandı. Anket sorularına verilen cevapların değerlendirilmesi için iki aşamalı lojistik regresyon yöntemi uygulandı. Araştırma sonucunda birinci ve ikinci çözümlemelerde doğru sınıflandırma oranları sırasıyla %89.00 ve %86.6 olarak bulundu. Sonuç olarak ; lojistik regresyon, klinik uygulamalarda elde edilen değişkenlerin her zaman süreklilik göstermemesi ve yöntemin bu değişkenlerle çözümleme yapabilmesi nedeniyle son yıllarda önemini arttırmaktadır.Öğe İnaktif trahomlu hastalarda impresyon sitolojisi(1998) Aksünger, Ahmet; Çelik, Yusuf; Karakaş, Nurettin; Ünlü, Kaan; Nergiz, Yusufİnaktif trahomlu olgularda, gözyaşı fonksiyon tesllerindeki değişikliklerin ve konjonktiva .litolojisinin, İmpresyon .litolojisi tekniği ile incelenmesi amacıyla İnaktif trahomlu 16 hastanın 24 gözüne Schirmer I ve gözyaşı kınlına zamanı teati uygulanmış, bulber ve palpebral konjonktivadan İmpresyon sitolojisi tekniği ile örnek alınmıştır. Alınan örneklerde goblet hücre savımı.yapılmış ve epitel hücre morfolojisi incelenerek skuamöz metaplazi derecelendirilip sonuçlar kontrol grubu ile karşılaştırılmıştır. Skatrizasvonun şiddeti ile orantılı olarak goblet hücrelerinde ve gözyaşı fonksiyon testlerinde azalma ve skuamöz metaplazide artış tespit ettik. İmpresyon sitolojisi tekniği, İnaktif trahomlu hastalarda konjonktiva sitolojisini değerlendirmede etkili, ucuz, çabuk ve ağrısız bir yöntem olarak saptanmıştır.Öğe To determine the occurence of afatoxin M1 (AFM1) in samples of cyprus traditional cheese (Halloumi): A cross-sectional study(Kafkas Üniversitesi Veteriner Fakültesi, 2014) Öztürk, Barış; Çelik, Fatma; Çelik, Yusuf; Kabaran, Seray; Ziver, TevhideThis Cross-Sectional present study was conducted to determine the occurence of afatoxin M1 (AFM1) in samples of Turkish Republicof North Cyprus (TRNC) traditional cheese (halloumi). In the current study a total of 128 halloumi cheese samples including 36 industrialmade and 92 home made were selected by using cluster sampling method and analyzed for AFM1 with the competitive ELISA. Thepercent of AFM1 contamination in halloumi cheese was found to be low, since 28.8% (0-16.66 ng/kg) of the samples were positive inindustrial made and 21.7% (0-4.63 ng/kg) in home made. The mean, standard error of mean (SEM), 95% Confidence Interval (95% CI)values of afatoxin M1 in halloumi cheese with industrial and home made samples were 0.84±0.24, (95% CI :0.35-1.35) and 1.28±0.32,(95% CI: 0.63-1.93) respectively. Both means were not significantly diference (P=0.422) and found very low from the limits of EuropeanCommission (EC) (250 ng/kg) and Turkish Food Codex (TFC) (500 ng/kg) (P<0.001). In order to prevent from introduction of afatoxin M1into cheese industry cycle, hygienic conditions, appropriate storage and control of livestock feed at all stages of planting and requiressystem that makes afatoxin control are necessary.
