• Terpenoid and fatty acid profiling along with anti-tyrosinase and anti-urease potentials of scorzonera pygmaea sibth. & sm. an endemic plant of Turkey 

  Şahin, Hasan; Boğa, Mehmet; Sarı, Aynur (Wiley-V C H Verlag GMBH, 2022)

  Petroleum ether (PE), chloroform (CH), ethyl acetate (EA) and butanol (BU) fractions were obtained from ethanol extracts of the roots (SPR) and the above ground (SPH) parts of S. pygmaea. PE fractions were evaluated by ...

• Kenevirin endüstri ve ilaç sanayiinde kullanım teknolojisi 

  Avcı, Mine Koçyiğit; Haspolat, Yusuf Kenan; Arıcan, Yağmur Emre; Dicle Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bililmleri Bölümü; 0000-0002-6910-2553; Arıcan, Yağmur Emre (Orient Yayınları, 2022)

  Tarihi kaynaklara göre en eski ekinlerden olan kenevirin kullanımı 12.000 yıl öncesine kadar uzanmaktadır, aynı zamanda en eski tarımsal ekinlerden biri olduğu vurgulanmaktadır (1). M.Ö 4000 yıllarında Çin’in Neolitik ...

• Unravelling the phenolic compound reserves, antioxidant and enzyme inhibitory activities of an endemic plant species, Achillea pseudoaleppica 

  Yılmaz, Mustafa Abdullah; Taslimi, Parham; Kılıç, Ömer; Gülçin, İlhami; Dey, Abhijit; Bursal, Ercan (Taylor & Francis, 2021)

  The present ethnobotanical study unravelled the phenolic reservoir (UHPLC-MS/TQ-MS) and pharmacological activity (antioxidant and enzyme inhibitory activities) of an endemic plant, Achillea pseudoaleppica Hub.-Mor. ...

• Enzyme inhibitory function and phytochemical profile of Inula discoidea using in vitro and in silico methods 

  Bursal, Ercan; Yılmaz, Mustafa Abdullah; İzol, Ebubekir; Türkan, Fikret; Atalar, Mehmet Nuri; Murahari, Manikanta; Aras, Abdulmelik; Ahmad, Mushtaq (Elsevier, 2021)

  Many plant species have a large diversity of secondary metabolites with different biological activities. This study aims to assess the phenolic constituent, enzyme inhibitory and antioxidant activities of the aqueous (water) ...

• Silane doped biodegradable starch-PLA bilayer films for food packaging applications: Mechanical, thermal, barrier and biodegradability properties 

  Gürler, Nedim; Paşa, Salih; Temel, Hamdi (Elsevier, 2021)

  In this work, pure potato starch (PPS) purified from waste potato starch, was recovered and used. PPS was modified by 3-APTMS (3-(aminopropyl) trimethoxy silane) to manufacture a crosslinked film. To obtain a bilayer ...

• Metal contents and chemometric evaluation of some medicinal plant species growing in different soil structures 

  Akyıldız, Mehmet Hayrullah; Ertaş, Abdulselam (Marmara Unıversity, 2021)

  Properties of the soil, state of the particules, class of the soil and air, water and the chemicals (calcium cations, humus, colloidal iron, aluminum, nitrogen, various polysaccharides etc.) that soil contains are the most ...

• Isolation of secondary metabolites of two endemic species: Salvia rosifolia Sm. and Salvia cerino-pruinosa Rech. f. var. elazigensis (Lamiaceae) 

  Yarış, Esra; Adsız, Leyla Balur; Yener, İsmail; Tuncay, Eyyüp; Yılmaz, Mustafa Abdullah; Akdeniz, Mehmet; Kaplaner, Erhan; Fırat, Mehmet; Ertaş, Abdulselam; Kolak, Ufuk (Springer, 2021)

  In the present study, activity-guided isolation and structural elucidation of antioxidant secondary metabolites of ethanol extracts prepared from the root and aerial parts of Salvia rosifolia and Salvia cerino-pruinosa ...

• Katı lipit nanopartiküller ve beyne özgü ilaç taşıyıcı sistem olarak uygulamaları 

  Toksoy, Mahmut Ozan; Tırnaksız, Fahriye Figen (Ankara Üniversitesi Eczacılık Fakültesi, 2021)

  Amaç: Son 20 yılda nanoteknolojik gelişmeler ile birlikte ilaç moleküllerinin beyne hedeflenmesine yönelik çalışmalarda artış gözlenmektedir. Beyin, kan dolaşımından kendine özgü bir bariyer ile ayrılmıştır. Kan-beyin ...

• Development of AMBER parameters for molecular dynamics simulations of boron compounds containing aromatic structure 

  Kurt, Barış; Temel, Hamdi (Elsevier, 2021)

  In this study, the Amber force field parameters for benzodioxaboroles which are boron compounds containing aromatic structure, were produced. The Root-Mean-Square Deviation (RMSD) value between the minimized geometries and ...

• Simultaneous quantification of phenolic acids and flavonoids in Chamaerops humilis L. using LC-ESI-MS/MS 

  Bouhafsoun, Aicha; Yılmaz, Mustafa Abdullah; Boukeloua, Ahmed; Temel, Hamdi; Kaid, Meriem Harche (Sociedade Brasileira de Ciencia e Tecnologia de Alimentos, SBCTA, 2018)

  In this study, heated reflux extraction method has been used to identify the phenolic compounds from C. humilis var. argentea leaflets, rachis and fruits. Extractions were performed in both ultrapure water and 80% methanol ...

• Chemical composition and pharmacological evaluation and of Ttddalia asiatica (Rutaceae) extracts and essential oil by in vitro and in silico approaches 

  Lobine, Devina; Pairyanen, Bryan; Zengin, Gökhan; Yılmaz, Mustafa Abdullah; Ouelbani, Rayene; Bensari, Souheir; Ak, Güneş; Abdallah, Hassan H.; Imran, Muhammad; Mahomoodally, Mohamad Fawzi (Wiley-V C H Verlag GMBH, 2021)

  Toddalia asiatica (L.) Lam. is extensively used in traditional medicinal systems by various cultures. Despite its frequent use in traditional medicine, there is still a paucity of scientific information on T. asiatica ...

• Volatile and phenolic profiling of a traditional medicinal plant, Hypericum empetrifolium with in vitro biological activities 

  Boğa, Mehmet; Ersoy, Ezgi; Özkan, Esra Eroğlu; Çınar, Ercan; Kara, Emel Mataracı; Cantürk, Yeter Yeşil; Zengin, Gökhan (Elsevier Ireland LTD, 2021)

  Ethnopharmacological relevance: Hypericum empetrifolium Willd is a member of the Hypericaceae family, mainly known in southern Greece, and western Turkey. Being a centuries-old medicinal plant, the aerial parts of the plant ...

• Molecular investigation of carbapenem and colistin resistance mechanisms in klebsiella pneumoniae bloodstream isolates 

  Genişel, Neslihan; Özcan, Nida; Gül, Kadri; Akpolat, Nezahat; Atmaca, Selahattin; Kenar, Levent; Altanlar, Nurten; Dal, Tuba (FABAD Ankara Eczacılık Bilimleri Derneği, 2021)

  Carbapenem-Resistant Klebsiella pneumoniae (CRKp) infections are worrying health problems due to decreasing treatment options. This study investigates the carbapenemase (OXA-23,24, 48, 51, 55, 58, KPC, NDM-1, VIM, IMP) and ...

• A comprehensive evaluation of the chemical profiles and biological properties of six geophytes from Turkey: Sources of bioactive compounds for novel nutraceuticals 

  Mahomoodally, Mohamad Fawzi; Zengin, Gökhan; Sinan, Kouadio Ibrahime; Yıldıztugay, Evren; Lobine, Devina; Ouelbani, Rayene; Bensari, Souheir; Ak, Güneş; Yılmaz, Mustafa Abdullah; Gallo, Monica; Montesano, Domenico (Elsevier, 2021)

  Geophytes are gaining interest as sources of natural ingredients in nutraceutical and pharmaceutical area. In this sense, six bulbous plant species from Turkey are investigated, namely Hyacinthella campanulata K.Perss. & ...

• Essential oil, aroma, and fatty acid profiles of five endemic Salvia taxa from Turkey with chemometric analysis 

  Ertaş, Abdulselam; Akdeniz, Mehmet; Yener, İsmail; Öztürk, Mehmet; Ölmez, Özge Tokul; Fırat, Mehmet; Kolak, Ufuk (Wiley-V C H Verlag GMBH, 2022)

  The essential oil, aroma, and fatty acid compositions of Salvia cerino-pruinosa var. cerino-pruinosa, S. cerino-pruinosa var. elazigensis, S. pseudeuphratica, S. rosifolia, and S. kurdica collected in 2015, 2016, and 2017 ...

• Synthesis and characterisation of novel tricyclic and tetracyclic furoindoles: Biological evaluation as SAHA enhancer against neuroblastoma and breast cancer cells 

  Bingül, Murat; Arndt, Greg M.; Marshall, Glenn M.; St. Black, David C.C.; Cheung, Belamy; Kumar, Naresh Sampath (MDPI, 2021)

  The dihydropyranoindole structures were previously identified as promising scaffolds for improving the anti-cancer activity of histone deacetylase inhibitors. This work describes the synthesis of related furoindoles and ...

• Synthesis, reactivity and biological properties of methoxy-activated indoles 

  Şengül, İbrahim F.; Bingül, Murat; Kandemir, Hakan; Kumar, Naresh; Black, David StC. (Society Chimica Italiana, 2021)

  Indoles continue to play a central role in the development of new structures of chemical and biological interest. They are the source of numerous biologically active natural products by virtue of their derivation from ...

• Design, synthesis and biological evaluation of 1,3-diaryltriazene-substituted sulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors 

  Akocak, Süleyman; Boğa, Mehmet; Lolak, Nabih; Tuneğ, Muhammed; Sanku, Rajesh Kishore Kumar (Turkish Chemical Society, 2019)

  1,3-diaryltriazenes are one of the most useful and important linkers for many pharmaceutical applications. Therefore, in the current work, a series of 1,3-diaryltriazene sulfonamides 4(a-k) were synthesized by reacting ...

• Determination of fingerprints contents of different extracts and parts of six endemic Salvia taxa by GC-MS: Source species for valuable compounds with drug or drug potential 

  Akdeniz, Mehmet; Yener, İsmail; Dinçel, Demet; Fırat, Mehmet; Değirmenci, Dilek Karataş; Ertaş, Abdulselam (Wiley, 2022)

  Public use of Salvia species and their importance in the scientific world is continually increasing. It is known that this use and the importance of Salvia species are mostly due to the terpenoid compounds that they contain. ...

• Cytotoxic and apoptotic effects of Hypericum androsaemum on prostate adenocarcinoma (PC-3) and hepatocellular carcinoma (Hep G2) cell lines with identification of secondary metabolites by LC-HRMS 

  Bektaş, Nurdan Yazıcı; Ersoy, Ezgi; Boğa, Mehmet; Boran, Tuğçe; Çınar, Ercan; Özhan, Gül; Gören, Ahmet Ceyhan; Özkan, Esra Eroğlu (Scientific Technical Research Council Turkey-TUBITAK, 2021)

  The study aims to determine the secondary metabolites of Hypericum androsaemum L. extracts by liquid chromatography-high resolution mass spectrometry (LC-HRMS), and investigate the antioxidant and cytotoxic activities of ...

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