Browsing Eczacılık Fakültesi Temel Eczacılık Bilimleri Bölümü Koleksiyonu by Title
Now showing items 1-20 of 21
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Anticholinesterase and antioxidant activities of novel heterocyclic Schiff base derivatives containing an aryl sulfonate moiety
(Wiley-V C H Verlag GMBH, 2022)In this research, nine novel heterocyclic Schiff base derivatives (10-18) bearing an aryl sulfonate moiety were designed, synthesized for the first time, and characterized. Then, their inhibitory effects on acetyl- and ... -
Antioxidant, acetylcholinesterase and butyrylcholinesterase inhibition profiles of histamine schiff bases
(Turkish Chemical Society, 2019)In this work, a series of histamine Schiff bases H(1-20) were assayed for antioxidant properties by using different bioanalytical methods such as DPPH-free radical scavenging assay, ABTS cation radical decolarization, ... -
Cannabinoids for SARS-CoV-2 and is there evidence of their therapeutic efficacy?
(Tubitak Scientific & Technical Research Council, 2021)Abstract: To combat the coronaviruses and their novel variants, therapeutic drugs and the development of vaccines that are to be effective throughout human life are urgently needed. The endocannabinoid system (ECS) acts ... -
A comparative bio-evaluation and chemical profiles of Calendula officinalis L. extracts prepared via different extraction techniques
(MDPI AG, 2020)Calendula officinalis L., (marigold), well known for its medicinal properties, has been extensively studied for its therapeutic properties. Nonetheless, as far as the literature could establish, no study has attempted to ... -
A comprehensive evaluation of the chemical profiles and biological properties of six geophytes from Turkey: Sources of bioactive compounds for novel nutraceuticals
(Elsevier, 2021)Geophytes are gaining interest as sources of natural ingredients in nutraceutical and pharmaceutical area. In this sense, six bulbous plant species from Turkey are investigated, namely Hyacinthella campanulata K.Perss. & ... -
Cytotoxic and apoptotic effects of Hypericum androsaemum on prostate adenocarcinoma (PC-3) and hepatocellular carcinoma (Hep G2) cell lines with identification of secondary metabolites by LC-HRMS
(Scientific Technical Research Council Turkey-TUBITAK, 2021)The study aims to determine the secondary metabolites of Hypericum androsaemum L. extracts by liquid chromatography-high resolution mass spectrometry (LC-HRMS), and investigate the antioxidant and cytotoxic activities of ... -
Design, synthesis and biological evaluation of 1,3-diaryltriazene-substituted sulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors
(Turkish Chemical Society, 2019)1,3-diaryltriazenes are one of the most useful and important linkers for many pharmaceutical applications. Therefore, in the current work, a series of 1,3-diaryltriazene sulfonamides 4(a-k) were synthesized by reacting ... -
Determination of fingerprints contents of different extracts and parts of six endemic Salvia taxa by GC-MS: Source species for valuable compounds with drug or drug potential
(Wiley, 2022)Public use of Salvia species and their importance in the scientific world is continually increasing. It is known that this use and the importance of Salvia species are mostly due to the terpenoid compounds that they contain. ... -
Ethnobotanical investigation of Pistacia lentiscus L. grown in El Kala (Algeria), and phytochemical study and antioxidant activity of its essential oil and extracts
(Taylor & Francis, 2021)Ethnobotanical investigation was carried out using questionnaires among majority of El Kala (Algeria) inhabitants. The investigation found that lentisk (Pistacia lentiscus L.) is widely used in traditional therapy, especially ... -
The Hemetsberger reaction: A new approach to the synthesis of novel dihydroindoloindole systems
(Arkat Usa Inc, 2020)The Hemetsberger indole synthesis provides an alternative method for the preparation of dihydroindoloindole systems. Two novel examples, dimethyl 3,8-dihydroindolo[7,6-g]indole-2,7-dicarboxylate and dimethyl 1,6dihydroin ... -
Heterocyclic Schiff base derivatives containing pyrazolone moiety: Synthesis, characterization, and in vitro biological studies
(Wiley, 2021)In this study, some pyrazolone-based Schiff base derivatives 2a-e (except 2a)were synthesized for the first time and structurally illuminated by some spec-troscopic techniques (1H,13C NMR, FT-IR) and elemental analysis. ... -
In Silico studies and DNA cleavage, antioxidant, acetylcholinesterase, and butyrylcholinesterase activity evaluation of bis-histamine schiff bases and bis-spinaceamine substituted derivatives
(Springer, 2022)In this work, a series of seven bis-histamine Schiff bases (H1-H4) and bis-spinaceamine substituted derivatives (SPH1, SPH2, and SPH4) were successfully re-synthesized to evaluate their antioxidant properties by several ... -
An LC-MS/MS method validation for the phytochemical quantification of four edible plants
(Iğdır Üniversitesi Fen Bilimleri Enstitüsü, 2018)A comprehensive LC-MS/MS method was developed and validated for the quantification of eight plant phytochemicals (cynarin, caffeic acid, syringic acid, p-coumaric acid, o-coumaric acid, vanillic acid, ferulic acid, chlorogenic ... -
Simultaneous quantification of phenolic acids and flavonoids in Chamaerops humilis L. using LC-ESI-MS/MS
(Sociedade Brasileira de Ciencia e Tecnologia de Alimentos, SBCTA, 2018)In this study, heated reflux extraction method has been used to identify the phenolic compounds from C. humilis var. argentea leaflets, rachis and fruits. Extractions were performed in both ultrapure water and 80% methanol ... -
Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile
(Taylor and Francis Ltd, 2020)A series of 16 novel benzenesulfonamides incorporating 1,3,5-triazine moieties substituted with aromatic amines, dimethylamine, morpholine and piperidine were investigated. These compounds were assayed for antioxidant ... -
Synthesis and characterisation of novel tricyclic and tetracyclic furoindoles: Biological evaluation as SAHA enhancer against neuroblastoma and breast cancer cells
(MDPI, 2021)The dihydropyranoindole structures were previously identified as promising scaffolds for improving the anti-cancer activity of histone deacetylase inhibitors. This work describes the synthesis of related furoindoles and ... -
Synthesis, characterization and biological evaluation of novel dihydropyranoindoles improving the anticancer effects of HDAC inhibitors
(MDPI AG, 2020)The dihydropyranoindole scaffold was identified as a promising target for improving the anti-cancer activity of HDAC inhibitors from the preliminary screening of a library of compounds. A suitable methodology has been ... -
Trace element analysis in some plants species by inductively coupled plasma optical emission spectrometry (ICP-OES)
(Iğdır Üniversitesi Fen Bilimleri Enstitüsü, 2019)In this study, the whole parts of eight edible and medicinal species (Alcea rosea, Carduuspycnocephalus subsp. albidus, Euphorbia gaillardotii, Euphorbia macroclada, Hypericum triquetrifolium,Kickxia lanigera, Malvella ... -
Trace element analysis in some salvia species by inductively coupled plasma-mass spectrometry (Icp-ms) and chemometric approach
(Marmara University, 2020)In this study, the stems, leaves, flowers, roots and mixed all parts of five Salvia species were analyzed for their trace element (Li, Be, V, Cr, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Ag, Cd, Cs, Ba, Hg, Tl, Pb, and U) contents ... -
Unravelling the phenolic compound reserves, antioxidant and enzyme inhibitory activities of an endemic plant species, Achillea pseudoaleppica
(Taylor & Francis, 2021)The present ethnobotanical study unravelled the phenolic reservoir (UHPLC-MS/TQ-MS) and pharmacological activity (antioxidant and enzyme inhibitory activities) of an endemic plant, Achillea pseudoaleppica Hub.-Mor. ...
