Browsing by Author "Cheung, Belamy"

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Synthesis and characterisation of novel tricyclic and tetracyclic furoindoles: Biological evaluation as SAHA enhancer against neuroblastoma and breast cancer cells

Bingül, Murat; Arndt, Greg M.; Marshall, Glenn M.; St. Black, David C.C.; Cheung, Belamy; Kumar, Naresh Sampath (MDPI, 2021)

The dihydropyranoindole structures were previously identified as promising scaffolds for improving the anti-cancer activity of histone deacetylase inhibitors. This work describes the synthesis of related furoindoles and ...
Synthesis, characterization and biological evaluation of novel dihydropyranoindoles improving the anticancer effects of HDAC inhibitors

Bingül, Murat; Arndt, Greg M.; Marshall, Glenn M.; Cheung, Belamy; Kumar, Naresh Sampath; Black, David St Clair (MDPI AG, 2020)

The dihydropyranoindole scaffold was identified as a promising target for improving the anti-cancer activity of HDAC inhibitors from the preliminary screening of a library of compounds. A suitable methodology has been ...