Ten cases of aquagenic syringeal acrokeratoderma revealed during the COVID-19 outbreak

Abstract

Aquagenic syringeal acrokeratoderma (ASA) is a rare, acquired disease affecting predominantly young women. It is characterised by the development of hypopigmented, translucent, flat‐topped, oedematous papules and plaques that form hyperwrinkling or keratoderma.1 It occurs after 3‐5 minutes of contact with water and resolves when the hand dries.1 Although its aetiology is not known exactly, it has been suggested that the disease may develop due to genetic predisposition or diseases such as cystic fibrosis, focal hyperhidrosis and Raynaud's phenomenon.2, 3 However, increased personal hygiene measures such as wearing personal protective equipment, excessive hand washing and disinfection in the COVID‐19 epidemic may play a role in the aetiology of ASA.5 Here we present ten cases with a very short history of ASA where lesions were first seen after the COVID‐19 outbreak.