Generalized pustular psoriasis in two children: Acitretin therapy: Case report

Abstract

Von Zumbusch type pustular psoriasis is rarely seen in pediatric patients. Attacks of pustular psoriasis are characterized by fever that lasts several days, followed by sudden onset of pustules. The pustules are disseminated over the trunk and extremities, including the nail beds palms, and soles. Acitretin, alone, or combined with oral corticosteroids, is the first-line treatment method. Methotrexate or cyclosporine may also be used. Acitretin is a second generation aromatic retinoid. It takes effect by regulating keratinocyte proliferation and differentiation. A two-yearold girl and a three-year-old boy, presented with widespread pustules on an erythematous background, accompanied by fever and leukocytosis. Skin and blood cultures were negative. A diagnosis of Von Zumbusch type pustular psoriasis was made. We present two pediatric cases of generalized pustular psoriasis responding to acitretin rapidly and effectively. Copyright © 2014 by Türkiye Klinikleri.