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dc.contributor.authorErsoy, Ezgi
dc.contributor.authorTanaman, Irmak
dc.contributor.authorÖzkan, Esra Eroğlu
dc.contributor.authorKarahan, Selim
dc.contributor.authorŞahin, Hasan
dc.contributor.authorÇınar, Ercan
dc.contributor.authorCantürk, Yeter Yeşil
dc.contributor.authorKara, Emel Mataracı
dc.contributor.authorZengin, Gökhan
dc.contributor.authorBoğa, Mehmet
dc.date.accessioned2023-08-04T07:46:23Z
dc.date.available2023-08-04T07:46:23Z
dc.date.issued2023en_US
dc.identifier.citationErsoy, E., Tanaman, I., Özkan, E. E., Karahan, S., Şahin, H., Çınar, E. ve diğerleri. (2023). Phytochemical analysis of essential oils and the extracts of an ethnomedicinal plant, Teucrium multicaule collected from two different locations with focus on their important biological activities. South African Journal of Botany, (153), 124-135.en_US
dc.identifier.issn0254-6299
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0254629922006779
dc.identifier.urihttps://hdl.handle.net/11468/12430
dc.description.abstractTeucrium species have been among the most commonly used traditional medicinal plants and they are known to have extensive therapeutic applications. The main focus of this study, Teucrium multicaule is also renowned for being an important medicinal and aromatic plant in Turkiye. Volatile profiling of the essential oils was conducted by GC MS, phytochemical profiling of the ethanol extracts was carried out by LC HRMS, antioxidant, anticholinesterase, antityrosinase, antiurease, antidiabetic, anticancer, and antimicrobial activities were revealed by different assays. Germacrene D was the most abundant compound in the essential oils from Diyarbakir (TmuD) with 45.4%, and Batman (TmuB) with 54.7%. All extracts were found to be quite rich in phytochemicals by LC HRMS, and herniarin, caffeic acid, naringenin, luteolin, scutellarein, hispidulin, rhamnocitrin, penduletin, eupatilin, (-)-epigallocatechin gallate, hederagenin, and verbascoside were found to be present in all extracts. T. multicaule roots extract from Diyarbakir (TmuRD) demonstrated the highest radical scavenging, a-amylase inhibitory (59.82§0.36%), and antibutyrylcholinesterase activity (61.96§ 1.72%), whereas T. multicaule aerial parts extract from Batman (TmuHB) exhibited the strongest antityrosinase (66.17§0.92%), antiurease (67.85§0.69%), and cytotoxic (54.76 § 1.57 mg/mL) activities. TmuRD also showed significant antimicrobial activity against S. epidermidis with 156.2 mg/mL MIC value. As revealed by this first detailed report on T. multicaule, the plant demonstrates various important biological activities attributed to its rich phytochemicals, which also justifies its use in ethnomedicine.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTeucrium multicauleen_US
dc.subjectLC-HRMSen_US
dc.subjectEnzyme inhibitory activityen_US
dc.subjectCytotoxicityen_US
dc.subjectTraditional usesen_US
dc.titlePhytochemical analysis of essential oils and the extracts of an ethnomedicinal plant, Teucrium multicaule collected from two different locations with focus on their important biological activitiesen_US
dc.typeArticleen_US
dc.identifier.issue153en_US
dc.identifier.startpage124en_US
dc.identifier.endpage135en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.authorid0000-0002-6913-1952en_US
dc.authorid0000-0002-1569-2535en_US
dc.authorid0000-0001-5784-7091en_US
dc.authorid0000-0002-8325-8116en_US
dc.authorid0000-0003-0419-7798en_US
dc.authorid0000-0002-4458-7881en_US
dc.authorid0000-0002-4428-5066en_US
dc.authorid0000-0001-6548-7823en_US
dc.authorid0000-0003-4163-9962en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.wosWOS:000921392400001
dc.identifier.wosWOS:000921392400001en_US
dc.identifier.scopus2-s2.0-85144454542en_US
dc.institutionauthorTanaman, Irmak
dc.institutionauthorKarahan, Selim
dc.institutionauthorŞahin, Hasan
dc.institutionauthorBoğa, Mehmet
dc.identifier.doi10.1016/j.sajb.2022.12.020en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US


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