2004-2006 yılları arasında izole edilen citrobacter suşlarında antibiyotik direnci

Abstract

Ocak 2004-Aral›k 2006 tarihleri aras›nda infeksiyon etkeni olarak izole edilen Citrobacter sufllar›n›n antibiyotik dirençlerinin belirlenmesi amaçlanm›flt›r. 73 Citrobacter suflundan 53’ü C.freundii, 9’u C.braakii, 3’ü C.koseri, 8’i C.youngae olarak identifiye edilmifltir. ‹zole edilen sufllar›n toplam›nda M‹K de¤erlerine göre direnç oranlar›na bak›ld›¤›nda ampisiline % 85, piperasiline % 63, piperasilin-tazobaktama % 47, sefoksitine % 84, seftazidime % 48, sefepime % 45, amikasine % 7, gentamisine % 38, aztreonama % 55, meropeneme % 1, siprofloksasine % 37, levofloksasine % 30 ve ko-trimoksazole % 48 oranlar›nda direnç saptanm›flt›r. Meropenem ve amikasin en etkili antibiyotikler olarak bulunmufl, bunlar› levofloksasin, siprofloksasin ve gentamisin izlemifltir.

The aim of this study is to detect the antibiotic resistance of Citrobacter strains isolated from clinical specimens between January 2004 and December 2006 as infection agents. 53 C.freundii, 9 C. braakii, 3 C.koseri and 8 C.youngae, totally 73 Citrobacter strains were isolated. When MIC values of isolates were taken into consideration altogether, rates of resistance were as follows; 85 % to ampicillin, 63 % to piperacillin-tazobactam, 47 % to cefoxitin, 84 % to cefoxitin, 48 % to ceftazidime, 45 % to cefepime, 7 % to amikacin, 38 % to gentamicin, 55 % to aztreonam, 1 % to meropenem, 37 % to ciprofloxacin, 30 % to levofloxacin and 48 % to cotrimoxazole. It is determined that the most efficient antibiotics are meropenem and amikacin, followed by levofloxacin, ciprofloxacin and gentamicin, respectively.