Browsing Moleküler Biyoloji ve Genetik Bölümü Koleksiyonu by Title
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Aldehyde dehydrogenase genes as prospective actionable targets in acute myeloid leukemia
(MDPI, 2023)It has been previously shown that the aldehyde dehydrogenase (ALDH) family member ALDH1A1 has a significant association with acute myeloid leukemia (AML) patient risk group classification and that AML cells lacking ALDH1A1 ... -
Antimicrobial and antioxidant effect of Ficaria verna Huds.
(Yüzüncü Yıl Üniversitesi Ziraat Fakültesi, 2021)Ficaria verna Huds. is a plant belonging to the Ranunculaceae family, known as mole grass and celandine among the people. It is known to have antiinflammatory and anti-haemorrhagic pharmaceutical effects. In this study, ... -
Characterization of a thermally stable ?-galactosidase produced by thermophilic anoxybacillus sp. AH1
(Bingöl Üniversitesi Fen Bilimleri Enstitüsü, 2021)Thermostable β-galactosidases from thermophilic bacteria have attracted increasing interest to have various advantages in industrial and biotechnological applications. In this study, a highly thermally stable β-galactosidase ... -
Critical roles of SRC-3 in the development and progression of breast cancer, rendering it a prospective clinical target
(MDPI, 31.10.2023)Breast cancer (BCa) is the most frequently diagnosed malignant tumor in women and is also one of the leading causes of cancer-related death. Most breast tumors are hormone-dependent and estrogen signaling plays a critical ... -
Decreased expression of HN1 sensitizes prostate cancer cells to apoptosis induced by Docetaxel and 2-Methoxyestradiol
(Association of Clinical Scientists, Inc., 2022)Objective: Prostate cancer is one of the most frequently diagnosed cancer in men and ranks as the second most common cause of cancer-related deaths in developed countries. HN1 is a highly expressed gene in prostate cancer ... -
Dissecting the effects of androgen deprivation therapy on cadherin switching in advanced prostate cancer: A molecular perspective
(Tech Science Press, 2022)Prostate cancer is one of the most often diagnosed malignancies in males and its prevalence is rising in both developed and developing countries. Androgen deprivation therapy has been used as a standard treatment approach ... -
Editorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment
(Frontiers, 2023)Acute leukemias remain a challenge, in spite of improvements in diagnosis and treatment. Fully establishing the depth and extent of the relative impact of the molecular mechanisms of disease progression and the pathways ... -
The effects of amino acids on production and transport of α-amylase through bacterial membranes
(Wiley-VCH Verlag, 2000)Bacillus subtilis was grown in media containing various amino acids. The effects of these aminoacids on the production of secreted alpha-amylase and membrane-bound alpha-amylase were investigated. Their effects on the ... -
Epithelial–mesenchymal transition in acute leukemias
(MDPI, 2024)Epithelial–mesenchymal transition (EMT) is a metabolic process that confers phenotypic flexibility to cells and the ability to adapt to new functions. This transition is critical during embryogenesis and is required for ... -
Essential oil compositions and antimicrobial activities of Thymbra spicata L. var. spicata L., Lavandula X Intermedia Emeric ex Loisel., Satureja macrantha C. A. MEYER and Rosmarinus officinalis L.
(Inst Tecnologia Parana, 2022)Medicinal and aromatic plants have been widely using in folk medicine as antimicrobial, anti-inflammatory and antinociceptive agents. The aim of this study was to determine essential oil composition and antimicrobial ... -
HN1 interacts with ?-tubulin to regulate centrosomes in advanced prostate cancer cells
(Taylor & Francis, 2021)Prostate cancer is one of the most common cancer for men worldwide with advanced forms showing supernumerary or clustered centrosomes. Hematological and neurological expressed 1 (HN1) also known as Jupiter Microtubule ... -
HN1 is enriched in the S-phase, phosphorylated in mitosis, and contributes to Cyclin B1 degradation in prostate cancer cells
(MDPI, 2023)HN1 has previously been shown as overexpressed in various cancers. In Prostate cancer, it regulates AR signaling and centrosome-related functions. Previously, in two different studies, HN1 expression has been observed ... -
Increased ROS alters E-/N-cadherin levels and promotes migration in prostate cancer cells
(Aepress, 2022)Background: Increased ROS has been reported to cause a change in E- and N-cadherin levels, and consequently promotes migrative behaviors in pancreas and breast cancer cells. In this study, the effect of a sublethal dose ... -
Innovative hydrogen release from sodium borohydride hydrolysis using biocatalyst-like Fe2O3 nanoparticles impregnated on Bacillus simplex bacteria
(Pergamon-Elsevier Science LTD, 2021)For the first time in this innovative study, microorganisms such as Bacillus simplex bacteria, mostly used in biological activity studies, are used as a bio-supporter agent of iron to release hydrogen from sodium borohydride ... -
Investigation of the occurrence of silene fuscata in Anatolia based on molecular analysis
(ABADER (Adıyaman Bilimsel Arastırmalar Dernegi), 2023)Silene fuscata is an annual species distributed to a wide geography including Eastern Mediterranean, Northern Africa, and Southern Europe. The native range of this species is known as the Mediterranean Region. Presence of ... -
Isolation and characterization of alkane hydrocarbons-degrading Delftia tsuruhatensis strain D9 from petroleum-contaminated soils
(Field Crops Central Research Institute, 2022)A bacterial strain from petroleum-contaminated soil in south-eastern Turkey was isolated and characterized to determine the potential of alkane hydrocarbon biodegradation. Phenotypic characteristics and the sequence analysis ... -
Isolation and characterization of alkane hydrocarbons-degrading enterobacter ludwigii strain D8 from petroleum-contaminated soils
(Bitlis Eren Üniversitesi, 2022)A bacterial strain has been isolated from petroleum contaminated soil with in southeastern Turkey. This isolated strain was characterized to determine its hydrocarbon biodegradation potential. Phenotypic features and of ... -
The Molecular context of oxidant stress response in cancer establishes ALDH1A1 as a critical target: What this means for acute myeloid leukemia
(MDPI, 2023)The protein family of aldehyde dehydrogenases (ALDH) encompasses nineteen members. The ALDH1 subfamily consists of enzymes with similar activity, having the capacity to neutralize lipid peroxidation products and to generate ... -
The nephroprotective effect of Quercetin in Cyclophosphamide-induced renal toxicity might be associated with MAPK/ERK and NF-κB signal modulation activity
(Taylor and Francis Ltd., 2024)The present study aimed to examine the protective effect of quercetin (QUE) on cyclophosphamide (CTX)-induced nephrotoxicity. For that purpose, 24 mice were divided into four groups (Control, QUE, CTX, and CTX + QUE). The ... -
OGG1 as an epigenetic reader affects NF?B: What this means for cancer
(MDPI, 2024)8-oxoguanine glycosylase 1 (OGG1), which was initially identified as the enzyme that catalyzes the first step in the DNA base excision repair pathway, is now also recognized as a modulator of gene expression. What is ...
