Moleküler Biyoloji ve Genetik Bölümü Koleksiyonu by Institution Author "Varışli, Lokman"
Now showing items 1-12 of 12
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Aldehyde dehydrogenase genes as prospective actionable targets in acute myeloid leukemia
Dancik, Garrett M.; Varışli, Lokman; Tolan, Veysel; Vlahopoulos, Spiros (MDPI, 2023)It has been previously shown that the aldehyde dehydrogenase (ALDH) family member ALDH1A1 has a significant association with acute myeloid leukemia (AML) patient risk group classification and that AML cells lacking ALDH1A1 ... -
Critical roles of SRC-3 in the development and progression of breast cancer, rendering it a prospective clinical target
Varışli, Lokman; Dancik, Garrett M.; Tolan, Veysel; Vlahopoulos, Spiros (MDPI, 31.10.2023)Breast cancer (BCa) is the most frequently diagnosed malignant tumor in women and is also one of the leading causes of cancer-related death. Most breast tumors are hormone-dependent and estrogen signaling plays a critical ... -
Decreased expression of HN1 sensitizes prostate cancer cells to apoptosis induced by Docetaxel and 2-Methoxyestradiol
Varışli, Lokman (Association of Clinical Scientists, Inc., 2022)Objective: Prostate cancer is one of the most frequently diagnosed cancer in men and ranks as the second most common cause of cancer-related deaths in developed countries. HN1 is a highly expressed gene in prostate cancer ... -
Dissecting the effects of androgen deprivation therapy on cadherin switching in advanced prostate cancer: A molecular perspective
Varışli, Lokman; Tolan, Veysel; Cen, Jiyan H.; Vlahopoulas, Spiros; Cen, Osman (Tech Science Press, 2022)Prostate cancer is one of the most often diagnosed malignancies in males and its prevalence is rising in both developed and developing countries. Androgen deprivation therapy has been used as a standard treatment approach ... -
Editorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment
Dancik, Garrett M.; Varışli, Lokman; Voutsas, Ioannis F.; Vlahopoulos, Spiros (Frontiers, 2023)Acute leukemias remain a challenge, in spite of improvements in diagnosis and treatment. Fully establishing the depth and extent of the relative impact of the molecular mechanisms of disease progression and the pathways ... -
Epithelial–mesenchymal transition in acute leukemias
Varışli, Lokman; Vlahopoulos, Spiros (MDPI, 2024)Epithelial–mesenchymal transition (EMT) is a metabolic process that confers phenotypic flexibility to cells and the ability to adapt to new functions. This transition is critical during embryogenesis and is required for ... -
HN1 interacts with ?-tubulin to regulate centrosomes in advanced prostate cancer cells
Varışli, Lokman; Javed, Aadil; Öztürk, Bilge Esin; Akyüz, Gencer Kaan; Takir, Gulevin; Fani-Marlen, Roumelioti; Gagos, Sarantis; Yörükoğlu, Kutsal; Korkmaz, Kemal Sami (Taylor & Francis, 2021)Prostate cancer is one of the most common cancer for men worldwide with advanced forms showing supernumerary or clustered centrosomes. Hematological and neurological expressed 1 (HN1) also known as Jupiter Microtubule ... -
HN1 is enriched in the S-phase, phosphorylated in mitosis, and contributes to Cyclin B1 degradation in prostate cancer cells
Javed, Aadil; Özduman, Gülseren; Varışli, Lokman; Öztürk, Bilge Esin; Kormaz, Kemal Sami (MDPI, 2023)HN1 has previously been shown as overexpressed in various cancers. In Prostate cancer, it regulates AR signaling and centrosome-related functions. Previously, in two different studies, HN1 expression has been observed ... -
Increased ROS alters E-/N-cadherin levels and promotes migration in prostate cancer cells
Varisli, Lokman; Tolan, Veysel (Aepress, 2022)Background: Increased ROS has been reported to cause a change in E- and N-cadherin levels, and consequently promotes migrative behaviors in pancreas and breast cancer cells. In this study, the effect of a sublethal dose ... -
The Molecular context of oxidant stress response in cancer establishes ALDH1A1 as a critical target: What this means for acute myeloid leukemia
Dancik, Garrett M.; Varışli, Lokman; Vlahopoulos, Spiros A. (MDPI, 2023)The protein family of aldehyde dehydrogenases (ALDH) encompasses nineteen members. The ALDH1 subfamily consists of enzymes with similar activity, having the capacity to neutralize lipid peroxidation products and to generate ... -
OGG1 as an epigenetic reader affects NF?B: What this means for cancer
Vlahopoulos, Spiros; Pan, Lang; Varışli, Lokman; Dancik, Garrett M.; Karantanos, Theodoros; Boldogh, Istvan (MDPI, 2024)8-oxoguanine glycosylase 1 (OGG1), which was initially identified as the enzyme that catalyzes the first step in the DNA base excision repair pathway, is now also recognized as a modulator of gene expression. What is ... -
Silencing of HN1L suppresses the proliferation and migration of cancer cells
Varışli, Lokman; Tolan, Veysel (2022)Background and purpose: HN1L is a member of the HN1 gene family and shares about 30% similarity with HN1 which is another member of the family on the primary protein sequence. Since HN1 is an important gene that is involved ...
