Moleküler Biyoloji ve Genetik Bölümü Koleksiyonu by Institution Author "Tolan, Veysel"
Now showing items 1-5 of 5
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Aldehyde dehydrogenase genes as prospective actionable targets in acute myeloid leukemia
Dancik, Garrett M.; Varışli, Lokman; Tolan, Veysel; Vlahopoulos, Spiros (MDPI, 2023)It has been previously shown that the aldehyde dehydrogenase (ALDH) family member ALDH1A1 has a significant association with acute myeloid leukemia (AML) patient risk group classification and that AML cells lacking ALDH1A1 ... -
Critical roles of SRC-3 in the development and progression of breast cancer, rendering it a prospective clinical target
Varışli, Lokman; Dancik, Garrett M.; Tolan, Veysel; Vlahopoulos, Spiros (MDPI, 31.10.2023)Breast cancer (BCa) is the most frequently diagnosed malignant tumor in women and is also one of the leading causes of cancer-related death. Most breast tumors are hormone-dependent and estrogen signaling plays a critical ... -
Dissecting the effects of androgen deprivation therapy on cadherin switching in advanced prostate cancer: A molecular perspective
Varışli, Lokman; Tolan, Veysel; Cen, Jiyan H.; Vlahopoulas, Spiros; Cen, Osman (Tech Science Press, 2022)Prostate cancer is one of the most often diagnosed malignancies in males and its prevalence is rising in both developed and developing countries. Androgen deprivation therapy has been used as a standard treatment approach ... -
Increased ROS alters E-/N-cadherin levels and promotes migration in prostate cancer cells
Varisli, Lokman; Tolan, Veysel (Aepress, 2022)Background: Increased ROS has been reported to cause a change in E- and N-cadherin levels, and consequently promotes migrative behaviors in pancreas and breast cancer cells. In this study, the effect of a sublethal dose ... -
Silencing of HN1L suppresses the proliferation and migration of cancer cells
Varışli, Lokman; Tolan, Veysel (2022)Background and purpose: HN1L is a member of the HN1 gene family and shares about 30% similarity with HN1 which is another member of the family on the primary protein sequence. Since HN1 is an important gene that is involved ...
