• The nephroprotective effect of Quercetin in Cyclophosphamide-induced renal toxicity might be associated with MAPK/ERK and NF-κB signal modulation activity 

  Şeker, Uğur; Kavak, Deniz Evrim; Dokumacı, Fatma Zehra; Kızıldağ, Sefa; Kandemir, Sevgi İrtegün (Taylor and Francis Ltd., 2024)

  The present study aimed to examine the protective effect of quercetin (QUE) on cyclophosphamide (CTX)-induced nephrotoxicity. For that purpose, 24 mice were divided into four groups (Control, QUE, CTX, and CTX + QUE). The ...

• Thermophilic and halophilic microorganisms isolated from extreme environments of Turkey, with potential biotechnological applications 

  Güven, Kemal; Bekler, Fatma Matpan; Güven, Reyhan Gül (Springer-Verlag Singapore Pte Ltd, 2018)

  Turkey has a great number of different ecological areas, owning over 200 hot water resources and various hypersaline environments with a broad microbial diversity and opportunities for newly isolated microorganisms from ...

• The toxicity of dithiocarbamate fungicides to soil nematodes, assessed using a stress-inducible transgenic strain of Caenorhabditis elegans 

  Güven, Kemal; Power, Rowena S.; Avramides, Sophia; Allender, Rebecca; de Pomerai, David I. (John Wiley and Sons Inc., 1999)

  The dithiocarbamate fungicides maneb and mancozeb induce a short-term stress response in a transgenic Caenorhabditis elegans strain (PC72) carrying a reporter lacZ gene under the control of a homologous heat shock (hsp16) ...

• Toxicity of the dithiocarbamate fungicide mancozeb to the nontarget soil nematode, Caenorhabditis elegans 

  Easton, Anna; Güven, Kemal; de Pomerai, David I. (Wiley, 2001)

  We have previously shown that the dithiocarbamate fungicide, Mancozeb, strongly induces lacZ reporter expression from an endogenous heat-shock promoter (hsp16) in the PC72 transgenic strain of the nematode Caenorhabditis ...

• The effects of amino acids on production and transport of α-amylase through bacterial membranes 

  Agüloǧlu, Sema; Ensari, N. Yavuz; Uyar, Fikret; Otludil, Birol (Wiley-VCH Verlag, 2000)

  Bacillus subtilis was grown in media containing various amino acids. The effects of these aminoacids on the production of secreted alpha-amylase and membrane-bound alpha-amylase were investigated. Their effects on the ...

• Investigation of the occurrence of silene fuscata in Anatolia based on molecular analysis 

  Toprak, Zeynep (ABADER (Adıyaman Bilimsel Arastırmalar Dernegi), 2023)

  Silene fuscata is an annual species distributed to a wide geography including Eastern Mediterranean, Northern Africa, and Southern Europe. The native range of this species is known as the Mediterranean Region. Presence of ...

• Epithelial–mesenchymal transition in acute leukemias 

  Varışli, Lokman; Vlahopoulos, Spiros (MDPI, 2024)

  Epithelial–mesenchymal transition (EMT) is a metabolic process that confers phenotypic flexibility to cells and the ability to adapt to new functions. This transition is critical during embryogenesis and is required for ...

• Characterization of a thermally stable ?-galactosidase produced by thermophilic anoxybacillus sp. AH1 

  Acer, Ömer; Bekler, Fatma Matpan (Bingöl Üniversitesi Fen Bilimleri Enstitüsü, 2021)

  Thermostable β-galactosidases from thermophilic bacteria have attracted increasing interest to have various advantages in industrial and biotechnological applications. In this study, a highly thermally stable β-galactosidase ...

• OGG1 as an epigenetic reader affects NF?B: What this means for cancer 

  Vlahopoulos, Spiros; Pan, Lang; Varışli, Lokman; Dancik, Garrett M.; Karantanos, Theodoros; Boldogh, Istvan (MDPI, 2024)

  8-oxoguanine glycosylase 1 (OGG1), which was initially identified as the enzyme that catalyzes the first step in the DNA base excision repair pathway, is now also recognized as a modulator of gene expression. What is ...

• Critical roles of SRC-3 in the development and progression of breast cancer, rendering it a prospective clinical target 

  Varışli, Lokman; Dancik, Garrett M.; Tolan, Veysel; Vlahopoulos, Spiros (MDPI, 31.10.2023)

  Breast cancer (BCa) is the most frequently diagnosed malignant tumor in women and is also one of the leading causes of cancer-related death. Most breast tumors are hormone-dependent and estrogen signaling plays a critical ...

• Isolation and characterization of alkane hydrocarbons-degrading Delftia tsuruhatensis strain D9 from petroleum-contaminated soils 

  Eren, Ayşe; Güven, Kemal (Field Crops Central Research Institute, 2022)

  A bacterial strain from petroleum-contaminated soil in south-eastern Turkey was isolated and characterized to determine the potential of alkane hydrocarbon biodegradation. Phenotypic characteristics and the sequence analysis ...

• Aldehyde dehydrogenase genes as prospective actionable targets in acute myeloid leukemia 

  Dancik, Garrett M.; Varışli, Lokman; Tolan, Veysel; Vlahopoulos, Spiros (MDPI, 2023)

  It has been previously shown that the aldehyde dehydrogenase (ALDH) family member ALDH1A1 has a significant association with acute myeloid leukemia (AML) patient risk group classification and that AML cells lacking ALDH1A1 ...

• Antimicrobial and antioxidant effect of Ficaria verna Huds. 

  İnci, Şule; Eren, Ayşe; Kırbağ, Sevda; Özkan, Ahmet İsmail (Yüzüncü Yıl Üniversitesi Ziraat Fakültesi, 2021)

  Ficaria verna Huds. is a plant belonging to the Ranunculaceae family, known as mole grass and celandine among the people. It is known to have antiinflammatory and anti-haemorrhagic pharmaceutical effects. In this study, ...

• The Molecular context of oxidant stress response in cancer establishes ALDH1A1 as a critical target: What this means for acute myeloid leukemia 

  Dancik, Garrett M.; Varışli, Lokman; Vlahopoulos, Spiros A. (MDPI, 2023)

  The protein family of aldehyde dehydrogenases (ALDH) encompasses nineteen members. The ALDH1 subfamily consists of enzymes with similar activity, having the capacity to neutralize lipid peroxidation products and to generate ...

• Editorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment 

  Dancik, Garrett M.; Varışli, Lokman; Voutsas, Ioannis F.; Vlahopoulos, Spiros (Frontiers, 2023)

  Acute leukemias remain a challenge, in spite of improvements in diagnosis and treatment. Fully establishing the depth and extent of the relative impact of the molecular mechanisms of disease progression and the pathways ...

• Essential oil compositions and antimicrobial activities of Thymbra spicata L. var. spicata L., Lavandula X Intermedia Emeric ex Loisel., Satureja macrantha C. A. MEYER and Rosmarinus officinalis L. 

  Karakaş, Özgür; Bekler, Fatma Matpan (Inst Tecnologia Parana, 2022)

  Medicinal and aromatic plants have been widely using in folk medicine as antimicrobial, anti-inflammatory and antinociceptive agents. The aim of this study was to determine essential oil composition and antimicrobial ...

• HN1 is enriched in the S-phase, phosphorylated in mitosis, and contributes to Cyclin B1 degradation in prostate cancer cells 

  Javed, Aadil; Özduman, Gülseren; Varışli, Lokman; Öztürk, Bilge Esin; Kormaz, Kemal Sami (MDPI, 2023)

  HN1 has previously been shown as overexpressed in various cancers. In Prostate cancer, it regulates AR signaling and centrosome-related functions. Previously, in two different studies, HN1 expression has been observed ...

• Silencing of HN1L suppresses the proliferation and migration of cancer cells 

  Varışli, Lokman; Tolan, Veysel (2022)

  Background and purpose: HN1L is a member of the HN1 gene family and shares about 30% similarity with HN1 which is another member of the family on the primary protein sequence. Since HN1 is an important gene that is involved ...

• Dissecting the effects of androgen deprivation therapy on cadherin switching in advanced prostate cancer: A molecular perspective 

  Varışli, Lokman; Tolan, Veysel; Cen, Jiyan H.; Vlahopoulas, Spiros; Cen, Osman (Tech Science Press, 2022)

  Prostate cancer is one of the most often diagnosed malignancies in males and its prevalence is rising in both developed and developing countries. Androgen deprivation therapy has been used as a standard treatment approach ...

• Isolation and characterization of alkane hydrocarbons-degrading enterobacter ludwigii strain D8 from petroleum-contaminated soils 

  Eren, Ayşe; Güven, Kemal (Bitlis Eren Üniversitesi, 2022)

  A bacterial strain has been isolated from petroleum contaminated soil with in southeastern Turkey. This isolated strain was characterized to determine its hydrocarbon biodegradation potential. Phenotypic features and of ...

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