• Cytotoxicity of endemic Haplophyllum megalanthum Bornm. and its newly isolated alkaloids and lignans 

  Demir, Serhat; Petersen, Malene Johanne; Kjaerulff, Louise; Somer, Nehir Unver; Staerk, Dan (Elsevier Ltd, 2024)

  In this study, two previously unreported lignans [4′-O-demetylsuchilactone-8′-ol (1), 7-O-(3-methyl-2,3-dihydroxy-butyl)isodaurinol] (2), four new alkaloids (haplomegalanthine (3), megalantin (4), megalanthamide (5), ...

• Some heterocycles connected to substituted piperazine by 1,3,4-oxadiazole linker: Design, synthesis, anticholinesterase and antioxidant activity 

  Kurt, Zuhal Kılıç; Konyar, Dilan; Okur, Hayati; Kaplan, Alevcan; Boǧa, Mehmet (Elsevier B.V., 2025)

  AD is a multifactorial neurodegenerative disease that has caused morbidity and mortality on a global scale. Currently, there are only a few drugs used in the treatment of AD. Although many compounds that aim at new targets ...

• A comprehensive study on chemical and biological investigation of thymus brachychilus jalas: A rich source of ursolic and oleanolic acids 

  Akdeniz, Mehmet; Yiğitkan, Serkan; Yılmaz, Mustafa Abdullah; Yener, İsmail; Varhan Oral, Elif; Fırat, Mehmet; Orhan, İlkay Erdoğan (Taylor & Francis Inc, 2023)

  The significance of Thymus species in the scientific community is growing steadily due to their extensive utilization in traditional medicine, food industry, and pharmaceutical sector, owing to their abundance in essential ...

• Hypoglycemic potential of 4,6-dimethoxyindole-7- and -2-thiosemicarbazone derivatives 

  Bingül, Murat; Şahin, Hasan (Dicle University, 2023)

  The hybrid molecules, derived from biologically active compounds, have been an open target for the medical researchers due to the possible enhanced biological properties. Hybridization of biologically active compounds for ...

• The computational and biological investigation of indole and quinoline based thiosemicarbazones towards ?-glucosidase enzyme inhibition 

  Bingül, Murat; Şahin, Hasan (Gaziantep University, 2022)

  Thiosemicarbazones are important classes of Schiff base ligands due to the presence of conjugated N-N-S system providing an important therapeutic potential and have been the subject of many structural and medicinal studies ...

• In-vitro anti-alzheimer activity of kırktekesakalı (Scorzonera pygmaea Sibth.&Sm.) 

  Şahin, Hasan; Boğa, Mehmet; Sarı, Aynur (Asos Yayınevi, 2021)

  Scorzonera L. cinsinin 50‘den fazla türü Türkiye‘de doğal olarak yetiĢmektedir. Asteraceae familyasına ait bu cinsin üyeleri dünyanın birçok bölgesinde hem gıda hem de halk ilacı olarak kullanılmaktadır. Bu çalıĢmada ...

• Uçucu yağlarda güvenlik riskleri: Aromaterapide madalyonun diğer yüzü 

  Şahin, Hasan; Doğan, Nesrin (Dicle Üniversitesi, 2022)

  Uçucu yağlar bitkilerin farklı kısımlarından elde edilen aromatik ve uçucu sıvılardır. Genelde distilasyon ile elde edilen bu sıvılar terpenik, aromatik bileşikler, azot ve kükürt taşıyan bileşikler, fenilpropan türevleri ...

• Diyarbakır ili Kulp ilçesinde yaygın olarak kullanılan yenilebilir yabani bitkiler 

  Subaşı, Fatoş Şekerciler; Şahin, Hasan; Demir, Serhat (Kriter Yayınevi, 2023)

  Diyarbakır ili Kulp ilçesinde yürütülen bu etnobotanik çalışma ile 18 farklı familyaya ait toplamda 37 yenilebilir yabani bitki türü kayıt altına alınmıştır. Belirlenen türlerin bilimsel botanik bilgileri, yöresel ve Türkçe ...

• Geleneksel/tamamlayıcı tıp ve tıbbi çaylar 

  Şahin, Hasan (Orient, 2022)

  Hastalıklar insanlık için her zaman bir sorun olmuştur. Zira güncel bilim bizlere hastalık etkeni mikroorganizmaların insandan önce de dünyada bulunduğunu göstermektedir. Bu durumda ilk insan dahi hastalıklarla mücadele ...

• Diyarbakır’dan toplanan Tragopogon longirostris Bisch. ex Schultz Bip. türü üzerinde farmakognozik araştırmalar 

  Şahin, Hasan (Bitkisel İlaç Hammaddeleri Toplantısı, 2022)

  Asteraceae familyasına ait Tragopogon L. cinsi dünya üzerinde yaklaşık 150 tür ile temsil edilmekte olup dünyanın farklı bölgelerinde ‘salsify’ adı altında sebze olarak tüketilmektedir. Türkiye’de 25 taksonu yetişen bu ...

• 60 yıldır yayınlanan bir eczacılık dergisi ve mesleğimize katkısı 

  Şahin, Hasan; Mat, Afife (Mersin Üniversitesi, 2014)

  Tüm meslek tarihlerinde olduğu gibi eczacılık tarihinde de meslek dergileri önemli bir yere sahiptir. Türkiye’de bu dergilerden önemli bazılarını; Resimli Eczacı Gazetesi (1924-1926), Türk Eczacı Âlemi (1927-1931), Farmakolog ...

• Chamazulene content and hypoglycemic potential of matricaria chamomilla L. samples collected from six different localities of Diyarbakır/Türkiye 

  Şahin, Hasan; Tunç, Ramazan; Subaşı, Fatoş Şekerciler (Adıyaman Bilimsel Araştırmalar Derneği, 2023)

  Chamomile (Matricaria chamomilla L.) is one of the oldest and most widely known medicinal plants belonging to Asteraceae family. An artifact named chamazulene forms from the sesquiterpene structured lactones such as matricin ...

• Chemical and Biological Perspectives of Monoterpene Indole Alkaloids From Rauwolfia species 

  Boğa, Mehmet; Bingül, Murat; Özkan, Esra Eroğlu; Şahin, Hasan (Elsevier, 2018)

  The biosynthesis of monoterpene indole alkaloids (MIAs) starts with a geraniol for the terpenoid portion. Secologanin, a secoiridoid glycoside, is derived from 10-hydroxygeraniol, produced in the presence of geraniol ...

• Attitudes and perceptions of pharmacy students toward pharmacognosy and related competencies of the national core education program in Türkiye 

  Şahin, Hasan; Gökkaya, İçim; Yazıcı, Nurdan (İstanbul Üniversitesi, 2023)

  Background and Aims: Competency-based education (CBE) and the use of natural health products have been increasingly discussed in pharmacy. The national core education program of Türkiye has 108 mandatory competencies. This ...

• Comparative phytochemical and bioactivity studies on two related Scorzonera L. species: A chemotaxonomic contribution 

  Şahin, Hasan; Demir, Serhat; Boğa, Mehmet; Sarı, Aynur; Makbul, Serdar; Gültepe, Mutlu (Elsevier, 2023)

  Scorzonera L. (Asteraceae) is considered a taxonomically difficult genus with its more than 160 species. Scorzonera bella (SB) and S. veratrifolia (SV) species have been treated as synonyms since 1975. Recent botanical ...

• Işgın (Rheum Ribes L.) bitkisinin hipoglisemik etkisi; Diyarbakır'da bir geleneksel tıp uygulaması 

  Şahin, Hasan; Üşenti, Berfin (Hayrullah Yazar, 2023)

  Amaç: Rheum ribes L. (Polygonaceae) dünyanın birçok bölgesinde hem gıda hem de diyabet dahil birçok hastalığa karşı geleneksel bir ilaç olarak kullanılmaktadır. Bu çalışmada bitkinin hipoglisemik potansiyelinin ve ...

• The Therapeutic potential of ethnomedicinally important Anatolian thyme species: A Phytochemical and biological assessment 

  Özkan, Esra Eroğlu; Ersoy, Ezgi; Cantürk, Yeter Yeşil; Kara, Emel Mataracı; Çınar, Ercan; Şahin, Hasan; Karahan, Selim; Sancaktepe, Kübra Karaca; Yılmaz, Mustafa Abdullah; Boğa, Mehmet (Frontiers, 09.06.2022)

  Thyme has been used for various therapeutic purposes in many different cultures, which makes it one of the most riveting medicinal plants throughout history. From its beneficial effects on the respiratory tract or the ...

• A Comprehensive study on a medicinal and edible plant scorzonera incisa DC., discussing the natural limits of phytochemical profiling 

  Şahin, Hasan; Demir, Serhat; Boğa, Mehmet; Sarı, Aynur; Makbul, Serdar; Coşkunçelebi, Kamil (Wiley, 2023)

  Leaves of Scorzonera incisa DC. (Asteraceae) are eaten raw against diabetes and headache. Evaluation of medicinal, edible plants using profiling methods has become a common phenomenon. Petroleum ether (PE), ethyl acetate ...

• 7-Acetoxyhorminone from Salvia multicaulis Vahl. as Promising Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase 

  Yiğitkan, Serkan; Ertaş, Abdulselam; Salmas, Ramin Ekhteiari; Fırat, Mehmet; Orhan, İlkay Erdoğan (MDPI, 2022)

  3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a key enzyme involved in cholesterol biosynthesis and one of the most important targets for the treatment of hy-percholesterolemia. A limited number of studies ...

• In-vitro anti-diabetic, anti-Alzheimer, anti-tyrosinase, antioxidant activities of selected coumarin and dihydroisocoumarin derivatives 

  Şahin, Hasan (İzzet Kara, 2023)

  Abstract: Benzo-α-pyrone structured coumarin derivatives are secondary metabolites first obtained from Coumarouna odorata in 1822. Coumarin and its structural isomer dihydroisocoumarin derivatives are found in many different ...

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