Browsing by Author "Uyar, Emre"
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Akut ketamin uygulamasının kognitif fonksiyonlar üzerine etkilerinin araştırılması
Uyar, Emre (Dicle Üniversitesi, Sağlık Bilimleri Enstitüsü, 2018)Amaç: Major Depresif Bozukluk tedavisinde kullanılan klasik ajanların etkilerinin belli bir periyod sonrasında baĢlaması ve vakaların önemli bir kısmında etkisiz kalmaları, yeni ve hızlı-etkili terapötik yaklaĢımlara ihtiyaç ... -
Anti-nociceptive effects of low dose ketamine in mice may be mediated by the serotonergic systems
Erdinç, Meral Alper; Uyar, Emre; Kelle, İlker; Akkoç, Hasan (Taylor and Francis Ltd., 2019)OBJECTIVE: In pain management, alternative medications are necessary due to the development of tolerance to traditional opioid analgesics. Literature data suggest that N-methyl-D-aspartate (NMDA) receptor antagonizing drugs ... -
A case-control study on depression, anxiety, and belief in sexual myths in trans women
Uyar, Betül; Yücel, İlyas; Uyar, Emre; Budak, Elif Ateş; Kelle, İlker; Bülbüloğlu, Semra (Frontiers Media S.A., 2023)Objective: The purpose of our study was to investigate depression, anxiety, and belief in sexual myths in trans women. Methods: This is a prospective case-control study. The case group included 60 trans women who were ... -
Deneysel diyabetin neden olduğu depresyon tedavisinde minosiklin ve minosiklin+metformin kullanımı
Çamçi, Merve İnci; Erdinç, Meral; Uyar, Emre; Kelle, İlker (Ankara Üniversitesi Eczacılık Fakültesi, 2022)Amaç: Minosiklin, santral sinir sistemine geçebilen, ikinci kuşak tetrasiklin grubu bir antibiyotiktir. Minosiklinin anti-inflamatuar, mikroglial aktivasyonu azaltma, anti-apoptotik, antioksidan özellikleri olduğu bilinmektedir. ... -
The Effects of Ethyl Pyruvate on Behavioral and BiochemicalParameters in Immobilization Stress-Induced Mice
Objective: Ethyl pyruvate (EP) is a molecule with antioxidant, anti-inflammatory, and anti-apoptotic features. The present study investigates EP's effects on behavioral and biochemical alterations induced by immobilization ... -
The effects of melatonin, fluoxetine and their combinations on stress induced behavioral and cognitive impairments in mice
Çamçi, Merve İnci; Erdinç, Meral; Kelle, İlker; Uyar, Emre; Erdinç, Levent (Ankara Üniversitesi Eczacılık Fakültesi, 2023)Objective: Melatonin (Mel) is a hormone with anti-depressant and anti-oxidant features. It is well known that melatonin protects brain cells from reactive oxygen species and that the brain's high oxygen consumption and ... -
Effects of Sublethal Doses of Thiacloprid, a Neonicotinoid Insecticide, on Learning and Memory Performance of Mice
Akkoc, Hasan; Acar, Abdullah; Toprak, Gulten; Uyar, Emre (Asian Network Scientific Information-Ansinet, 2020)Background and Objective: Thiacloprid (THI), a neonicotinoid insecticide, currently one of the most preferred insecticides worldwide. Although they are claimed to be less hazardous on mammals, late studies revealed the ... -
Exenatide Treatment Exerts Anxiolytic- and Antidepressant-Like Effects and Reverses Neuropathy in a Mouse Model of Type-2 Diabetes
Celikyurt, Ipek Komsuoglu; Mutlu, Oguz; Ulak, Guner; Uyar, Emre; Bektas, Emine; Akar, Furuzan Yildiz; Erden, Faruk (Int Scientific Information, Inc, 2014)Background: Comorbid neurobehavioral disturbances and type-2 diabetes mellitus (T2DM) warrant immediate research attention. Exenatide, which is a potent and selective agonist for the glucagon-like peptide-1 (GLP-1), is ... -
Investigating the Effects of Trolox on Behaviour and Biochemical Parameters in Mice Exposed to Immobilization Stress
Toprak, Gulten; Akkoc, Hasan; Uyar, Emre (Asian Network Scientific Information-Ansinet, 2019)Background and Objective: Stress is known to play a causal role in several neuropsychiatric disorders. Trolox has been reported to show potent antioxidant activity against reactive oxygen species. The aim of this study was ... -
Investigation of the effects of Trpc4/5 inhibitor M084 in experimental alzheimer’s-likedementia model
Güneş, Ali; Akkoç, Hasan; Uyar, Emre (Kırşehir Ahi Evran Üniversitesi, 2022)Purpose: This study aimed to research the effects of N-butyl-1H]-benzimidazole-2-amine (M084) on cognitive functions in an experimental Alzheimer-like dementia model.Materials and Methods: In our study, male rats were ... -
İn vivo sıçan kalbinde oluşturulan iskemi reperfüzyon hasarında Rosuvastatin'in koruyucu etkisinin iskemik önkoşullama ile karşılaştırılması
Uyar, Emre (2015)İskemi sonrası reperfüzyonun yol açtığı ağır oksidatif stres ciddi işlevsel ve yapısal hasara yol açamaktadır. Bu hasardan başlıca serbest oksijen radikalleri sorumlu tutulmaktadır. Son yıllarada farklı organlarda yapılan ... -
QbD application for a fixed-dose combination with biowaiver potential: Evaluations of In vitro and In vivo applications
Yaşın, Diren Sarısaltık; Uslu, Abdullah; Uyar, Emre; Erdinç, Meral; Teksin, Zeynep Şafak (Springer, 2022)Purpose The purpose of this study was to use the quality by design (QbD) approach to design a directly compressed fixed-dose combination (FDC) tablet comprising amlodipine besylate and enalapril maleate with biowaiver ... -
Trolox is more successful than allopurinol to reduce degenerative effects of testicular ischemia/reperfusion injury in rats
Seker, Ugur; Nergiz, Yusuf; Aktas, Ayfer; Akkus, Murat; Ozmen, Mehmet Ferit; Uyar, Emre; Soker, Sevda (Elsevier Sci Ltd, 2020)Introduction Reperfusion surgery following testicular ischemia is a reproductive health threatening status and may result with organ dysfunction in men. The high level of reactive oxygen species (ROS) and cease of blood ...
