Browsing by Author "Dancik, Garrett M."
Now showing items 1-5 of 5
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Aldehyde dehydrogenase genes as prospective actionable targets in acute myeloid leukemia
Dancik, Garrett M.; Varışli, Lokman; Tolan, Veysel; Vlahopoulos, Spiros (MDPI, 2023)It has been previously shown that the aldehyde dehydrogenase (ALDH) family member ALDH1A1 has a significant association with acute myeloid leukemia (AML) patient risk group classification and that AML cells lacking ALDH1A1 ... -
Critical roles of SRC-3 in the development and progression of breast cancer, rendering it a prospective clinical target
Varışli, Lokman; Dancik, Garrett M.; Tolan, Veysel; Vlahopoulos, Spiros (MDPI, 31.10.2023)Breast cancer (BCa) is the most frequently diagnosed malignant tumor in women and is also one of the leading causes of cancer-related death. Most breast tumors are hormone-dependent and estrogen signaling plays a critical ... -
Editorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment
Dancik, Garrett M.; Varışli, Lokman; Voutsas, Ioannis F.; Vlahopoulos, Spiros (Frontiers, 2023)Acute leukemias remain a challenge, in spite of improvements in diagnosis and treatment. Fully establishing the depth and extent of the relative impact of the molecular mechanisms of disease progression and the pathways ... -
The Molecular context of oxidant stress response in cancer establishes ALDH1A1 as a critical target: What this means for acute myeloid leukemia
Dancik, Garrett M.; Varışli, Lokman; Vlahopoulos, Spiros A. (MDPI, 2023)The protein family of aldehyde dehydrogenases (ALDH) encompasses nineteen members. The ALDH1 subfamily consists of enzymes with similar activity, having the capacity to neutralize lipid peroxidation products and to generate ... -
OGG1 as an epigenetic reader affects NF?B: What this means for cancer
Vlahopoulos, Spiros; Pan, Lang; Varışli, Lokman; Dancik, Garrett M.; Karantanos, Theodoros; Boldogh, Istvan (MDPI, 2024)8-oxoguanine glycosylase 1 (OGG1), which was initially identified as the enzyme that catalyzes the first step in the DNA base excision repair pathway, is now also recognized as a modulator of gene expression. What is ...
