Browsing by Author "Şahin, Hasan"
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60 yıldır yayınlanan bir eczacılık dergisi ve mesleğimize katkısı
Şahin, Hasan; Mat, Afife (Mersin Üniversitesi, 2014)Tüm meslek tarihlerinde olduğu gibi eczacılık tarihinde de meslek dergileri önemli bir yere sahiptir. Türkiye’de bu dergilerden önemli bazılarını; Resimli Eczacı Gazetesi (1924-1926), Türk Eczacı Âlemi (1927-1931), Farmakolog ... -
The anticholinesterase perspective of dimethoxyindole based benzenesulfonamides: Synthesis, biological investigation and molecular docking applications
Bingül, Murat; Ercan, Selami; Boǧa, Mehmet; Arslan, Zehra; Tuneğ, Muhammed; Akocak, Süleyman; Bingül, Alev Arslantürk; Şengül, İbrahim Fazıl; Şahin, Hasan (John Wiley and Sons Inc., 2024)Due to the well-known biological potential of benzenesulfonamides for the inhibition of specific enzymes, here in, we propose to investigate anticholinesterase efficiencies of five newly synthesized benzenesulfonamides ... -
Attitudes and perceptions of pharmacy students toward pharmacognosy and related competencies of the national core education program in Türkiye
Şahin, Hasan; Gökkaya, İçim; Yazıcı, Nurdan (İstanbul Üniversitesi, 2023)Background and Aims: Competency-based education (CBE) and the use of natural health products have been increasingly discussed in pharmacy. The national core education program of Türkiye has 108 mandatory competencies. This ... -
Biological and computational evaluation of carbazole-based bis-thiosemicarbazones: A selective enzyme inhibition study between ?-amylase and ?-glucosidase
Şahin, Hasan; Bingül, Alev Arslantürk; Şengül, İbrahim Fazıl; Bingül, Murat (Istanbul University, 2023)Background and Aims: Carbazole heterocyclic systems are an important class of chemicals that have been reported as valuable antidiabetic agents in the literature. Uncoincidentally, the ayurvedic antidiabetic plant Murraya ... -
Chamazulene content and hypoglycemic potential of matricaria chamomilla L. samples collected from six different localities of Diyarbakır/Türkiye
Şahin, Hasan; Tunç, Ramazan; Subaşı, Fatoş Şekerciler (Adıyaman Bilimsel Araştırmalar Derneği, 2023)Chamomile (Matricaria chamomilla L.) is one of the oldest and most widely known medicinal plants belonging to Asteraceae family. An artifact named chamazulene forms from the sesquiterpene structured lactones such as matricin ... -
Chemical and Biological Perspectives of Monoterpene Indole Alkaloids From Rauwolfia species
Boğa, Mehmet; Bingül, Murat; Özkan, Esra Eroğlu; Şahin, Hasan (Elsevier, 2018)The biosynthesis of monoterpene indole alkaloids (MIAs) starts with a geraniol for the terpenoid portion. Secologanin, a secoiridoid glycoside, is derived from 10-hydroxygeraniol, produced in the presence of geraniol ... -
Comparative phytochemical and bioactivity studies on two related Scorzonera L. species: A chemotaxonomic contribution
Şahin, Hasan; Demir, Serhat; Boğa, Mehmet; Sarı, Aynur; Makbul, Serdar; Gültepe, Mutlu (Elsevier, 2023)Scorzonera L. (Asteraceae) is considered a taxonomically difficult genus with its more than 160 species. Scorzonera bella (SB) and S. veratrifolia (SV) species have been treated as synonyms since 1975. Recent botanical ... -
A Comprehensive study on a medicinal and edible plant scorzonera incisa DC., discussing the natural limits of phytochemical profiling
Şahin, Hasan; Demir, Serhat; Boğa, Mehmet; Sarı, Aynur; Makbul, Serdar; Coşkunçelebi, Kamil (Wiley, 2023)Leaves of Scorzonera incisa DC. (Asteraceae) are eaten raw against diabetes and headache. Evaluation of medicinal, edible plants using profiling methods has become a common phenomenon. Petroleum ether (PE), ethyl acetate ... -
The computational and biological investigation of indole and quinoline based thiosemicarbazones towards ?-glucosidase enzyme inhibition
Bingül, Murat; Şahin, Hasan (Gaziantep University, 2022)Thiosemicarbazones are important classes of Schiff base ligands due to the presence of conjugated N-N-S system providing an important therapeutic potential and have been the subject of many structural and medicinal studies ... -
Diyarbakır ili Kulp ilçesinde yaygın olarak kullanılan yenilebilir yabani bitkiler
Subaşı, Fatoş Şekerciler; Şahin, Hasan; Demir, Serhat (Kriter Yayınevi, 2023)Diyarbakır ili Kulp ilçesinde yürütülen bu etnobotanik çalışma ile 18 farklı familyaya ait toplamda 37 yenilebilir yabani bitki türü kayıt altına alınmıştır. Belirlenen türlerin bilimsel botanik bilgileri, yöresel ve Türkçe ... -
Diyarbakır’dan toplanan Tragopogon longirostris Bisch. ex Schultz Bip. türü üzerinde farmakognozik araştırmalar
Şahin, Hasan (Bitkisel İlaç Hammaddeleri Toplantısı, 2022)Asteraceae familyasına ait Tragopogon L. cinsi dünya üzerinde yaklaşık 150 tür ile temsil edilmekte olup dünyanın farklı bölgelerinde ‘salsify’ adı altında sebze olarak tüketilmektedir. Türkiye’de 25 taksonu yetişen bu ... -
Geleneksel/tamamlayıcı tıp ve tıbbi çaylar
Şahin, Hasan (Orient, 2022)Hastalıklar insanlık için her zaman bir sorun olmuştur. Zira güncel bilim bizlere hastalık etkeni mikroorganizmaların insandan önce de dünyada bulunduğunu göstermektedir. Bu durumda ilk insan dahi hastalıklarla mücadele ... -
Hypoglycemic potential of 4,6-dimethoxyindole-7- and -2-thiosemicarbazone derivatives
Bingül, Murat; Şahin, Hasan (Dicle University, 2023)The hybrid molecules, derived from biologically active compounds, have been an open target for the medical researchers due to the possible enhanced biological properties. Hybridization of biologically active compounds for ... -
In-vitro anti-alzheimer activity of kırktekesakalı (Scorzonera pygmaea Sibth.&Sm.)
Şahin, Hasan; Boğa, Mehmet; Sarı, Aynur (Asos Yayınevi, 2021)Scorzonera L. cinsinin 50‘den fazla türü Türkiye‘de doğal olarak yetiĢmektedir. Asteraceae familyasına ait bu cinsin üyeleri dünyanın birçok bölgesinde hem gıda hem de halk ilacı olarak kullanılmaktadır. Bu çalıĢmada ... -
In-vitro anti-diabetic, anti-Alzheimer, anti-tyrosinase, antioxidant activities of selected coumarin and dihydroisocoumarin derivatives
Şahin, Hasan (İzzet Kara, 2023)Abstract: Benzo-α-pyrone structured coumarin derivatives are secondary metabolites first obtained from Coumarouna odorata in 1822. Coumarin and its structural isomer dihydroisocoumarin derivatives are found in many different ... -
Indolyl imine compounds as multi-target agents; synthesis, antidiabetic, anticholinesterase, antioxidant activities and molecular modeling
Ceyhan, Sadık M.; Zengin, İrem Nur; Bingül, Murat; Şahin, Hasan; Boǧa, Mehmet; Sağlam, Mehmet F.; Kandemir, Hakan (Elsevier B.V., 2024)A new range of indolyl imine system 3d-l has been successfully prepared from 4,6-dimethoxy-2,3-diphenyl-indole-7-carbaldehyde 2a and 4,6-dimethoxy-3-aryl-indole-7-carbaldehyde 2b-c via Schiff base reaction. The structure ... -
Işgın (Rheum Ribes L.) bitkisinin hipoglisemik etkisi; Diyarbakır'da bir geleneksel tıp uygulaması
Şahin, Hasan; Üşenti, Berfin (Hayrullah Yazar, 2023)Amaç: Rheum ribes L. (Polygonaceae) dünyanın birçok bölgesinde hem gıda hem de diyabet dahil birçok hastalığa karşı geleneksel bir ilaç olarak kullanılmaktadır. Bu çalışmada bitkinin hipoglisemik potansiyelinin ve ... -
Phenolic compounds and bioactivity of Scorzonera pygmaea Sibth. & Sm. aerial parts: In vitro antioxidant, anti-inflammatory and antimicrobial activities
Şahin, Hasan; Sarı, Aynur; Özsoy, Nurten; Çelik, Berna Özbek (Istanbul University, 2020)Abstract Background and Aims: Scorzonera L. genus contains several medicinal and edible plants. Both roots and aerial parts of Scorzonera species are used. S. pygmaea is endemic to Turkey. in a previous study, nine phenolic ... -
Phytochemical analysis of essential oils and the extracts of an ethnomedicinal plant, Teucrium multicaule collected from two different locations with focus on their important biological activities
Ersoy, Ezgi; Tanaman, Irmak; Özkan, Esra Eroğlu; Karahan, Selim; Şahin, Hasan; Çınar, Ercan; Cantürk, Yeter Yeşil; Kara, Emel Mataracı; Zengin, Gökhan; Boğa, Mehmet (Elsevier, 2023)Teucrium species have been among the most commonly used traditional medicinal plants and they are known to have extensive therapeutic applications. The main focus of this study, Teucrium multicaule is also renowned for ... -
Synthesis and molecular modeling studies of naphthazarin derivatives as novel selective inhibitors of ?-glucosidase and ?-amylase
Abadan, Şebnem; Sağlam, Mehmet F.; Koca, Mehmet Serdar; Bingül, Murat; Şahin, Hasan; Zorlu, Yunus; Şengül, İbrahim F. (Elsevier B.V., 2023)Diabetes mellitus is known as one of the most life-threatening diseases and has attracted the attention of medicinal chemists. The design and synthesis of novel potential candidates for the inhibition of αamylase and ...
