Browsing by Author "Çınar, Ercan"
Now showing items 1-13 of 13
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Cytotoxic and apoptotic effects of Hypericum androsaemum on prostate adenocarcinoma (PC-3) and hepatocellular carcinoma (Hep G2) cell lines with identification of secondary metabolites by LC-HRMS
Bektaş, Nurdan Yazıcı; Ersoy, Ezgi; Boğa, Mehmet; Boran, Tuğçe; Çınar, Ercan; Özhan, Gül; Gören, Ahmet Ceyhan; Özkan, Esra Eroğlu (Scientific Technical Research Council Turkey-TUBITAK, 2021)The study aims to determine the secondary metabolites of Hypericum androsaemum L. extracts by liquid chromatography-high resolution mass spectrometry (LC-HRMS), and investigate the antioxidant and cytotoxic activities of ... -
Evaluation of the medicinal potential of a traditionally important plant from Turkey: Cerinthe minor L.
Ersoy, Ezgi; Karahan, Selim; Boğa, Mehmet; Çınar, Ercan; İzgi, Sevcan; Kara, Emel Mataracı (Istanbul University Press, 2022)Background and Aims: Cerinthe minor L. has been used for both culinary and medicinal purposes in Turkey. Since the plant has remained uninvestigated pharmacognostically, this study aims to provide data on the phytochemical ... -
Heterocyclic Schiff base derivatives containing pyrazolone moiety: Synthesis, characterization, and in vitro biological studies
Çınar, Ercan; Başaran, Eyüp; Erdoğan, Ömer; Çakmak, Reşit; Boğa, Mehmet; Çevik, Özge (Wiley, 2021)In this study, some pyrazolone-based Schiff base derivatives 2a-e (except 2a)were synthesized for the first time and structurally illuminated by some spec-troscopic techniques (1H,13C NMR, FT-IR) and elemental analysis. ... -
İnek sütünden izole edilen Bacillus sp.’den pullulanaz ve α-amilaz enzimlerinin üretimi, bu enzimlerin bazı optimizasyon koşullarının belirlenmesi
Çınar, Ercan (2017)Günümüz biyoteknolojisinde enzimlerin kullanımı giderek önem kazanmaktadır. Bu enzimlerden α-amilaz ve pullulanaz önemli biyoteknolojik enzimler arasındadır. α- Amilazlar ve pullulanazlar, nişastanın hidrolizi için gıda, ... -
Phytochemical analysis of essential oils and the extracts of an ethnomedicinal plant, Teucrium multicaule collected from two different locations with focus on their important biological activities
Ersoy, Ezgi; Tanaman, Irmak; Özkan, Esra Eroğlu; Karahan, Selim; Şahin, Hasan; Çınar, Ercan; Cantürk, Yeter Yeşil; Kara, Emel Mataracı; Zengin, Gökhan; Boğa, Mehmet (Elsevier, 2023)Teucrium species have been among the most commonly used traditional medicinal plants and they are known to have extensive therapeutic applications. The main focus of this study, Teucrium multicaule is also renowned for ... -
Schiff base derivatives of 4-aminoantipyrine as promising molecules: Synthesis, structural characterization, and biological activities
Çakmak, Reşit; Başaran, Eyüp; Boğa, Mehmet; Erdoğan, Ömer; Çınar, Ercan; Çevik, Özge (Pleiades journals, 2022)Abstract: In this study, some Schiff bases derived from 4-aminoantipyrine (4-AAP) (VI–X) were synthesized, characterized by elemental analysis (C, H, N) and three spectral techniques (FT-IR, 1H, and 13C NMR), and then their ... -
SOME NOVEL SCHIFF BASE DERIVATIVES AS PROMISING CHOLINESTERASE INHIBITORS WITH ANTIOXIDANT ACTIVITY AGAINST ALZHEIMER’S DISEASE: SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION
Boğa, Mehmet; Çınar, Ercan; Topal, Giray; Çakmak, Reşit (2022)In this study, five novel Schiff base derivatives (6-10) except for 9 were synthesized for the first time, characterized, and tested for their inhibition activities against acetylcholinesterase (AChE) and butyrylcholinesterase ... -
Syntheses of some hydrazones derived from 2-(aryloyloxy) benzaldehydes and 2,4-dinitrophenylhydrazine and evaluation of their anticholinesterase and antioxidant activities
Çınar, Ercan; Topal, Giray (ACG Publications, 2022)In this research, five novel hydrazone derivatives (2a-e) were obtained for the first time, characterized and investigated for their antioxidant properties, and acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) ... -
Synthesis of novel N-Acylhydrazones derived from 3,5-dinitrobenzohydrazide and evaluation of their anticholinesterase and antioxidant activities
Çakmak, Reşit; Çınar, Ercan; Başaran, Eyüp; Tuneğ, Gülsüm; İzgi, Sevcan; Boǧa, Mehmet (Pleiades Publishing, 2024)Abstract: Objective: In this study, it was aimed to determine the antioxidant activities and enzyme inhibition properties of newly synthesized N-acylhydrazone compounds (IIIa–IIIp) bearing an aryl sulfonate moiety. Methods: ... -
Synthesis, characterization and biological evaluation of esterderivatives of 4-(diethylamino) salicylaldehyde cholinesterase and tyrosinase inhibitors
Çakmak, Reşit; Çınar, Ercan; Başaran, Eyüp; Boğa, Mehmet (INESEG Yayıncılık, 2021)Alzheimer's disease, one of the diseases that still has no a specific therapy, has become amajor public health issue owing to the increasing population of the elderly, particularly in richcountries. Inhibitory of cholinesterase ... -
Synthesis, spectroscopic, thermal analysis and in vitro cytotoxicity, anticholinesterase and antioxidant activities of new Co(II), Ni(II), Cu(II), Zn(II), and Ru(III) complexes of pyrazolone-based Schiff base ligand
Çakmak, Reşit; Ay, Burak; Çınar, Ercan; Başaran, Eyüp; Akkoç, Senem; Boğa, Mehmet; Taş, Eşref (Elsevier B.V., 2023)Metal-based drugs have gained significant importance in medicine in recent years. In this research, a series of new Co(II), Ni (II), Cu (II), Zn(II), and Ru(III) complexes of a Schiff base ligand, (1,5-dimethyl-4-((1-(3 ... -
The Therapeutic potential of ethnomedicinally important Anatolian thyme species: A Phytochemical and biological assessment
Özkan, Esra Eroğlu; Ersoy, Ezgi; Cantürk, Yeter Yeşil; Kara, Emel Mataracı; Çınar, Ercan; Şahin, Hasan; Karahan, Selim; Sancaktepe, Kübra Karaca; Yılmaz, Mustafa Abdullah; Boğa, Mehmet (Frontiers, 09.06.2022)Thyme has been used for various therapeutic purposes in many different cultures, which makes it one of the most riveting medicinal plants throughout history. From its beneficial effects on the respiratory tract or the ... -
Volatile and phenolic profiling of a traditional medicinal plant, Hypericum empetrifolium with in vitro biological activities
Boğa, Mehmet; Ersoy, Ezgi; Özkan, Esra Eroğlu; Çınar, Ercan; Kara, Emel Mataracı; Cantürk, Yeter Yeşil; Zengin, Gökhan (Elsevier Ireland LTD, 2021)Ethnopharmacological relevance: Hypericum empetrifolium Willd is a member of the Hypericaceae family, mainly known in southern Greece, and western Turkey. Being a centuries-old medicinal plant, the aerial parts of the plant ...
