Otcu, SerapDeveci, Engin2024-04-242024-04-2420210884-6812https://hdl.handle.net/11468/22539OBJECTIVE: To investigate the immunohistochemical staining of hypoxia-inducible factor 1-alpha (HIF-1 alpha) and Ki-67 expression in the placenta of pregnant women with placenta previa and placenta accreta. STUDY DESIGN: Thirty placentas (10 normotensive, 10 placenta previa, and 10 placenta accreta) were processed for routine histological tissue processing. The biochemical parameters of patients were recorded. Placentas were stained with hematoxylin-eosin and HIF-1 alpha and Ki-67 immunostaining. RESULTS: Normal histology was observed in placentas of normotensive pregnant women. Placenta previa sections showed increased syncytial knots, intervillous hemorrhage, fibrin accumulation, and hyalinization. In placenta accreta sections, increased syncytial nodes, vascular dilation/congestion, fibrin accumulation, and hyalinization were observed. Normotensive placentas showed no HIF-1 alpha expression. In placenta previa tissues, high HIF-1 alpha expression was observed in vascular endothelial cells, villous stromal cells, and syncytial knots. High HIF-1 alpha expression was recorded in villous stromal cells and cytotrophoblast cells in placenta accreta. In normotensive placental tissues, no Ki-67 expression was observed. In placenta previa sections, high Ki-67 expression was observed mostly in root villi stromal cells and some endothelial cells. High Ki-67 expression was observed mostly in villi stromal cells of placenta accreta. CONCLUSION: It is thought that HIF-1 alpha is an important regulatory gene in the development of villus in trophoblast invasion such as placenta accreta and previa, while Ki-67 will play a key role in the development of abnormal placenta with its stimulating effect on inflammatory cell development and angiogenesis in accreta and preeclampsia.eninfo:eu-repo/semantics/closedAccessFemaleHypoxiaHypoxia-Inducible Factor 1Alpha SubunitPlacentaPlacenta AccretaPlacenta PreviaPlacental LactogenPregnancyPhysiologyPreeclampsiaArticle433143149WOS:000691771000006Q4