Togrul, CihanGorkem, UmitIrtegun, SevgiTahaoglu, Ali EmreGungor, TayfunDeveci, Engin2024-04-242024-04-2420170884-6812https://hdl.handle.net/11468/20894OBJECTIVE: To examine histopathologic changes and correlation between TNF-alpha and pSTAT3 expression levels by western blot and immunohistochemical methods in preeclamptic placentas. STUDY DESIGN: Obstetrical properties and bio-chemical and hematological features of patients with preeclampsia and healthy subjects were compared. Paraffin sections obtained from placenta were stained with hematoxylin-eosin for histopathologic examination. RESULTS: In histopathologic examination of preeclamptic placentas, cytotrophoblastic cellular proliferation, fibrinoid necrosis, endothelial proliferation, and calcified and hyalinized villous spots were observed. CONCLUSION: In preeclamptic placentas, we observed that trophoblastic invasion may downregulate STAT3 phosphorylation and can correlate with TNF-alpha elevation. Even though trophoblast invasion may interfere with both vascular and immune systems, TNF-alpha is not directly involved in the STAT3 signaling pathway in the preeclamptic placenta. (Anal Quant Cytopathol Histpathol 2017; 39: 149-156)eninfo:eu-repo/semantics/closedAccessPlacentaPreeclampsiaStat3Tnf-AlphaArticle393149156WOS:0004043983000052-s2.0-85020546699Q4Q4