Demirtas, AbdullahAzboy, IbrahimBulut, MehmetUcar, Bekir YavuzAlemdar, CelilAlabalik, UlasAkpolat, Veysi2024-04-242024-04-2420141306-696Xhttps://doi.org/10.5505/tjtes.2014.52323https://search.trdizin.gov.tr/yayin/detay/227485https://hdl.handle.net/11468/20182BACKGROUND: The aim of the present study was to investigate the effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats. METHODS: Thirty-two rats were divided as follows: nicotinized group (1), hyperbaric oxygen group (2), nicotinized + hyperbaric oxygen group (3), and control group (4). For 28 days, nicotine was administered in Groups 1 and 3. Then, a standard shaft fracture was induced in the left femur of rats. Groups 2 and 3 underwent hyperbaric oxygen therapy for 21 days. At the end of the experiment, fracture site, left femur and whole body bone mineral content and density were measured. RESULTS: The radiological and histopathological scores of Group 1 were statistically significantly lower compared to Groups 2, 3 and 4, and there was no statistically significant difference between the Groups 2, 3 and 4. In a comparison between the groups, no statistically significant difference was found in terms of bone mineral content and density values measured at the fracture site, left femur and whole body. CONCLUSION: The negative effects of nicotine on fracture healing are eliminated with hyperbaric oxygen therapy, but hyperbaric oxygen alone does not cause significant changes in healing (radiologically and histopathologically).eninfo:eu-repo/semantics/openAccessFracture HealingHyperbaric OxygenNicotineArticle203161166WOS:0003371636000022-s2.0-849016707372274852493683610.5505/tjtes.2014.52323Q3Q4