Durap, FeyyazAydemir, MuratElma, DuyguBaysal, AkinTurgut, Yilmaz2024-04-242024-04-2420131631-07481878-1543https://doi.org/10.1016/j.crci.2012.12.003https://hdl.handle.net/11468/15311Asymmetric transfer hydrogenation processes of ketones with chiral molecular catalysts are attracting increasing interest from synthetic chemists due to their operational simplicity. C-2-symmetric catalysts have also received much attention and been used in many reactions. A series of new chiral C-2-symmetric bis(phosphinite) ligands has been prepared from corresponding amino acid derivated amino alcohols or (R)-2-amino-1-butanol through a three- or four-step procedure. Their structures have been elucidated by a combination of multinuclear NMR spectroscopy, IR spectroscopy and elemental analysis. H-1-P-31 NMR, DEPT, H-1-C-13 HETCOR or H-1-H-1 COSY correlation experiments were used to confirm the spectral assignments. In situ prepared ruthenium catalytic systems were successfully applied to ruthenium-catalyzed asymmetric transfer hydrogenation of acetophenone derivatives by iso-PrOH. Under optimized conditions, these chiral ruthenium catalyst systems serve as catalyst precursors for the asymmetric transfer hydrogenation of acetophenone derivatives in iso-PrOH and act as good catalysts, giving the corresponding optical secondary alcohols in 99% yield and up to 79% ee. (C) 2012 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.eninfo:eu-repo/semantics/openAccessHomogeneous CatalysisAsymmetric Transfer HydrogenationChiral Phosphinite LigandsRutheniumC-2-SymmetryArticle164363371WOS:0003204798000092-s2.0-8487694934510.1016/j.crci.2012.12.003Q3Q2