Aydemir, MuratMeric, NerminBaysal, AkinGumgum, BahattinTogrul, MahmutTurgut, Yilmaz2024-04-242024-04-2420100957-4166https://doi.org/10.1016/j.tetasy.2010.04.002https://hdl.handle.net/11468/16105Hydrogen-transfer reduction processes are attracting increasing interest from synthetic chemists in view of their operational simplicity. The new chiral C-2-symmetric ligands N,N'-bis-[(1S)-1-sec-butyl-2-O-(diphenylphosphinite)ethyl]ethanediamide, 1 and N,N'-bis-[(1S)-1-phenyl-2-O-(diphenylphosphinite)ethyl]ethanediamide, 2 and the corresponding ruthenium complexes 3 and 4 have been prepared and their structures have been elucidated by a combination of multi-nuclear NMR spectroscopy, IR spectroscopy, and elemental analysis. H-1-P-31 NMR, DEPT, H-1-C-13 HETCOR, or H-1-H-1 COSY correlation experiments were used to confirm the spectral assignments. The catalytic activity of complexes 3 and 4 in transfer hydrogenation of acetophenone derivatives by iso-PrOH has also been studied. Under optimized conditions, these chiral ruthenium complexes serve as catalyst precursors for the asymmetric transfer hydrogenation of acetophenone derivatives in iso-PrOH and act as excellent catalysts, giving the corresponding chiral alcohols in 99% yield and up to 75% ee. This transfer hydrogenation is characterized by low reversibility under these conditions. (C) 2010 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccess[No Keyword]Article216703710WOS:0002790662000102-s2.0-7795313578710.1016/j.tetasy.2010.04.002N/AQ2