Yılmaz, HayrullahTopal, GirayÇakmak, ReşitHoşgören, Halil2024-04-242024-04-242010Yılmaz, H., Topal, G., Çakmak, R. ve Hoşgören, H. (2010). Resolution of (±)-β-methylphenylethylamine by a novel chiral stationary phase for Pirkle-type column chromatography. Chirality, 22(2), 252-257.0899-00421520-636Xhttps://doi.org/10.1002/chir.20736https://hdl.handle.net/11468/14011https://onlinelibrary.wiley.com/doi/10.1002/chir.20736In this study, a new Pirkle-type chiral column stationary phase for resolution of beta-methylphenylethyl amine was described by using activated Sepharose 4B as a matrix, L-tyrosine as a spacer arm, and an aromatic amine derivative of L-glutamic acid as a ligand. The binding capacities of the stationary phase were determined at different pH values (pH = 6, 7, and 8) using buffer solutions as mobile phase, and enantiomeric excess (ee) was determined by HPLC equipped with chiral column. The ee was found to be 47%. Chirality 22:252-257, 2010. (C) 2009 Wiley-Liss, Inc.eninfo:eu-repo/semantics/closedAccessSepharose 4bResolutionChiral aminesHplcPirkle-type column chromatographyArticle222252257WOS:0002736283000102-s2.0-747490840341949613610.1002/chir.20736Q2Q1