Karakaplan, MehmetJameel, Basam2024-04-242024-04-2420160957-4166https://doi.org/10.1016/j.tetasy.2016.05.009https://hdl.handle.net/11468/16114A series of amino alcohol imides 2-8 have been synthesized from commercially available starting materials by regioselective ring opening reaction of epoxides with chiral amines. Compounds 2-8 were tested as chiral solvating agents (CSAs) for enantiomeric discrimination of biological important carboxylic acids. C-2-Symmetric (S,R,R,S)-3 was found to be a satisfactory CSA for mandelic acid with Delta Delta delta of 24.8 Hz. CSA (S, S)-5 exhibited the best enantiomeric discrimination for alpha-phenyl-alpha-methoxyacetic acid with Delta Delta delta of 32 Hz. Enantiomeric differentiated values found for mandelic acid, o-chloro mandelic acid, ibuprofen and naproxen are 7.2, 4.4, 2 and 3 Hz respectively. (C) 2016 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccess[No Keyword]Article2714-15597602WOS:0003804198000012-s2.0-8497687323910.1016/j.tetasy.2016.05.009N/AQ2