Turgut, Fatma SubaşıBulut, MahmutHattapoğlu, SalihGüneş, MehmetKaya, Mehmet CemalEkici, FaysalÇetinçakmak, Mehmet Guli2024-04-242024-04-242024Turgut, F. S., Bulut, M., Hattapoğlu, S., Güneş, M., Kaya, M. C., Ekici, F. ve diğerleri. (2024). The relationship between oxidative stress markers and 1H-Magnetic resonance spectroscopy findings in obsessive compulsive disorder. Brain Research, 1833, 1-7.0006-8993https://doi.org/10.1016/j.brainres.2024.148852https://hdl.handle.net/11468/23292Introduction: The purpose of this study was to examine N-acetyl aspartate (NAA)/creatine (Cr) and glutamate, glutamine, and gamma-aminobutyric acid complex (Glx)/Cr levels in patients with obsessive compulsive disorder (OCD) and healthy controls’ orbitofrontal cortex (OFC) and caudate nucleus (CN) by proton magnetic resonance spectroscopy (1H-MRS) method and to investigate their relationship with oxidative stress markers glutathione peroxidase (GPx) and superoxide dismutase (SOD). Methods: This study included patients with OCD (n = 25) and healthy controls (n = 25) ranging in age from 18 to 65. We used the ELISA method to evaluate serum SOD and GPx levels. Levels of NAA/Cr and Glx/Cr in the orbitofrontal cortex and caudate nucleus were measured using the 1H-MRS method. Results: Our study did not detect statistically significant differences in the orbitofrontal cortex Glx/Cr and NAA/Cr levels between the OCD patients and the control group. OCD patients exhibited a decrease in NAA/Cr levels, consistent with impaired neuronal integration, and an increase in Glx/Cr levels, consistent with hyperactivation, in the caudate nucleus compared to the control group. We observed a negative correlation between NAA/Cr levels in the caudate nucleus and the levels of SOD and GPx. Conclusions: Our study is the first to assess CN and OFC together in OCD patients using 3 T MR, investigating the relationship between neurometabolite concentrations and oxidative stress parameters. The negative correlation we observed between NAA/Cr levels and SOD and GPx in the caudate nucleus suggests that increased oxidative stress in this brain region in OCD patients may contribute to impaired neuronal integration and functionality. © 2024 Elsevier B.V.eninfo:eu-repo/semantics/closedAccessNeuronal integrityObsessive-compulsive disorderOxidative stressSingle proton magnetic resonance spectroscopyArticle18332-s2.0-851885281003849409910.1016/j.brainres.2024.148852Q2