Meriç, NerminRafikova, KhadichakhanZazybin, AlexeyGüzel, RemziyeKayan, CezmiKarakas, Duygu ElmaDündar, AbdurrahmanAydemir, Murat2024-04-242024-04-242023Meriç, N., Rafikova, K., Zazybin, A., Güzel, R., Kayan, C., Karakas, D.E. ve diğerleri (2023). Application of half-sandwich metal-phosphinite compounds to biological activities: Determine the energies of the HOMO and LUMO levels. Environmental Toxicology, 23(6), 672–678.0044-23131521-3749https://doi.org/10.1002/zaac.202200126https://hdl.handle.net/11468/14140https://onlinelibrary.wiley.com/doi/epdf/10.1002/zaac.202200126Mononuclear transition metal complexes 1-(furan-2-yl)ethyldiphenyl[dichloro(eta(6)-p-cymene)ruthenium(II)]phosphinite, (2), 1-(furan-2-yl)ethyldiphenyl[dichloro(eta(6)-benzene) ruthenium(II)] phosphinite (3), 1-(furan-2-yl)ethyldipheny[chloro(eta(4)-1,5-cyclooctadiene)rhodium(I)]phosphinite (4), 1-(furan-2-yl)ethyldiphenyl[dichloro (eta(5)pentamethylcyclopentadienyl)iridium (III)] phosphinite (5) were synthesized and characterized by microanalysis, infrared, MS, and NMR spectroscopy. The biological activities of the complexes were also tested. Compounds 2 and 5 were the best complexes at DPPH radical scavenging and reducing power activity at 73.27 % and 0.41 at 200 mu g/mL, respectively. The highest antimicrobial activity exhibited by complex 3 as 14 mm inhibition zone against S. aureus. All of the complexes have cleaved the DNA from the double-strand and exhibited three bands on gel electrophoresis. Moreover, cyclic voltammetry studies of the phosphinite complexes were carried out to determine the energies of the HOMO and LUMO levels as well as to estimate their electrochemical and some electronic properties.eninfo:eu-repo/semantics/closedAccessPhosphinite ligandTransition metalBiological studyElectron transportArticle6492WOS:0008883973000012-s2.0-8514227257610.1002/zaac.202200126Q3Q4