Ak, BünyaminDurap, FeyyazAydemir, MuratBaysal, Akın2024-04-242024-04-242015Ak, B., Durap, F., Aydemir, M. ve Baysal, A. (2015). Ruthenium(II) complexes derived from C2-symmetric ferrocene-based chiral bis(phosphinite) ligands: Synthesis and catalytic activity towards the asymmetric reduction of acetophenones. Applied Organometallic Chemistry, 29(11), 764-770.0268-26051099-0739https://doi.org/10.1002/aoc.3364https://hdl.handle.net/11468/13967https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.3364Chiral secondary alcohols are very important building blocks and valuable synthetic intermediates both in organic synthesis and in the pharmaceutical industry for producing biologically active complex molecules. A series of new chiral Ru-phosphinite complexes (1, 2, 3, 4, 5, 6, 7, 8) were prepared from chiral C-2-symmetric ferrocenyl phosphinites and corresponding chloro complex, [Ru((6)-p-cymene)(-Cl)Cl](2). The complexes were characterized using conventional spectroscopic methods. The binuclear complexes were tested as pre-catalysts and were found to be good pre-catalysts for the asymmetric transfer hydrogenation of substituted acetophenones in basic 2-propanol at 82 degrees C, providing the corresponding optically active alcohols with almost quantitative conversion and modest to high enantioselectivities (46-97%). Amongst the all complexes, complex 6 gave the highest ee of 97% in the reduction of 2-methoxyacetophenone to (S)-1-(2-methoxyphenyl)ethanol at 82 degrees C. Copyright (c) 2015 John Wiley & Sons, Ltd.eninfo:eu-repo/semantics/closedAccessFerrocenyl bis(Phosphinite)C-2 symmetryAsymmetric transfer hydrogenationAcetophenoneRutheniumArticle2911764770WOS:0003638827000082-s2.0-8494648367110.1002/aoc.3364Q1Q2