High levels of high-sensitivity C-reactive protein and impaired autonomic activity in smokers

Alyan, OmerKacmaz, FehmiOzdemir, OzcanKarahan, ZulkufTaskesen, TuncayIyem, HikmetAlan, Sait2024-04-242024-04-2420081016-5169https://hdl.handle.net/11468/20962Objectives: We investigated the relationship between high sensitivity C-reactive protein (hs-CRP) activity and autonomic nervous activity using heart rate variability in smokers. Study design: The study consisted of 136 healthy subjects, including 66 smokers (35 women, 31 men; mean age 36 years) and 70 nonsmokers (43 women, 27 men; mean age 34 years). Serum samples were collected from all the subjects. Three-channel, 24-hr Holter monitoring was performed to derive the mean heart rate, standard deviation of normal NN intervals (SDNN), standard deviation of 5-minute mean NN intervals (SDANN), root mean square differences of successive NN intervals (RMSSD), high-(HF) and low-(LF) frequency power components, and the LF/HF ratio. Results: In smokers, the mean duration of smoking was 13.6 +/- 8.2 years (range 3 to 45 years), and the mean number of cigarettes consumed per day was 16.3 +/- 7.1 (range 5 to 40). Smokers exhibited significantly higher mean heart rate, hs-CRP and fibrinogen levels, mean platelet volume, white blood cell count, LF, and LF/HF ratio, with significantly lower SDNN, SDANN, RMSSD, and HF values. In smokers, hs-CRP was correlated with the number of cigarettes consumed per day, duration of smoking, fibrinogen level, mean platelet volume, white blood cell count, LF, and LF/HF ratio, and inversely correlated with HF, SDNN, and SDANN. Even smoking a single cigarette resulted in an acute, 0.07-fold increase in the hs-CRP level (p< 0.0001). In linear regression analysis, both the number of cigarettes consumed per day (beta= 0.52, p= 0.011) and duration of smoking (beta= 0.073, p< 0.0001) had an independent effect on the hs-CRP level. Conclusion: Smoking both impairs the sympathovagal balance and increases the hs-CRP activity in otherwise healthy smokers, the combination of which would probably contribute to a higher rate of cardiovascular events.trinfo:eu-repo/semantics/closedAccessC-Reactive Protein/AnalysisElectrocardiographyHeart Rate/PhysiologyRisk FactorsSmoking/Adverse EffectsSympathetic Nervous System/PhysiologyHigh levels of high-sensitivity C-reactive protein and impaired autonomic activity in smokersHigh levels of high-sensitivity C-reactive protein and impaired autonomic activity in smokersArticle366368375WOS:0004214331000022-s2.0-6884911709319155639Q3N/A