Ocal, E.Akalin, S. AlkanAsir, F.2024-04-242024-04-2420231128-3602https://hdl.handle.net/11468/21284OBJECTIVE: In this study, we investigated the immunohistochemical staining of cited-1 and caspase-6 expression in the placentas of pregnant women with HELLP syndrome.PATIENTS AND METHODS: Placentas of 20 normotensive patients and 20 women with HELLP syndrome were processed for routine histological tissue processing. The biochemical and clinical parameters of patients were record-ed. Placentas were stained with hematoxylin-eosin and cited-1 and caspase-6 immunostaining.RESULTS: Placentas of normotensive patients showed normal histology. Placentas of women with HELLP syndrome showed degenerated cells, hyalinization and vacuolization. Cited-1 ex-pression was negative in normotensive group; however, it was increased in HELLP group, especially in decidual cells, endothelial cells and other placental cells. Caspase-6 expression was negative in placental structures of normotensive groups. However, it was intense in decidual cells, vacuolar and hyalinized areas, inflammatory cells and connective tissue cells in HELLP group.CONCLUSIONS: Cited-1 and caspase-6 are a marker in determining the severity of HELLP syndrome.eninfo:eu-repo/semantics/closedAccessHellpPlacentaCited-1Caspase-6Article27730823087WOS:0009826461000142-s2.0-8515297325537070911Q2N/A