Özevren, HüseyinDeveci, EnginTuncer, Cudi Mehmet2021-08-172021-08-172020Özevren, H., Deveci, E. ve Tuncer, C. M. (2020). The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of iba-1 and gfap expressions. Acta Cirurgica Brasileira, 35(4), 1-10.0102-8650https://www.scielo.br/j/acb/a/hnnxfWwKrN7nhqfrf5JVqVg/?lang=enhttps://hdl.handle.net/11468/7336Purpose: To investigate the role of Rosmarinic acid (RA) in the prevention of traumatic brain inand the immunohistochemical analysis of IBA-1 and GFAP expressions.Methods: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows; control group, traumatic brain injury (TBI) group, and TBI+RA group. After traumatic brain injury, blood samples were taken from the animals and analyzed with various biochemical markers. And then IBA-1 and GFAP expressions were evaluated immunohistochemically.Results: Significant results were obtained in all biochemical parameters between groupImmunohistochemical sections showed IBA-1 not only in microglia and macrophage activity but alsin degenerative neurons in blood vessel endothelial cells. However, GFAP reaction and post-traumatirosmarinic acid administration showed positive expression in astrocytes with regular structure arounthe blood vessel.Conclusion: Rosmarinic acid in blood vessel endothelial cells showed that preserving the integrity of astrocytic structure in the blood brain barrier may be an important antioxidant.trinfo:eu-repo/semantics/openAccessBrain InjuriesTraumaticGlial fibrillary acidic proteinRatRosmarinic acidArticle354110WOS:0005436902000012-s2.0-850870284863257872410.1590/s0102-865020200040000006Q2Q4